Limited effect of recombinant porcine interleukin-12 on porcine lymphocytes due to a low level of IL-12 beta2 receptor

Veterinary Immunology and Immunopathology

Volumn 89, Issue 3-4, 2002, Pages 133-148

  Solano Aguilar, G I ^a   Zarlenga, D ^a   Beshah, E ^a   Vengroski, K ^a   Gasbarre, L ^a   Junker, D ^a   Cochran, M ^a   Weston, C ^a   Valencia, D ^a   Chiang, C ^a   Dawson, H ^a   Urban, J F ^a   Lunney, J K ^a  

^a BELTSVILLE HUMAN NUTRITION RESEARCH CENTER   (United States)

Author keywords

IFN ; IL 12 receptor; Interleukin 12; Porcine cellular immunity; Swine poxvirus

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; MESSENGER RNA; RECOMBINANT CYTOKINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATTLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; INGUINAL LYMPH NODE; LYMPHOBLAST; LYMPHOCYTE; MOLECULAR CLONING; MONONUCLEAR CELL; NONHUMAN; POXVIRUS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL ASSAY; BLOTTING, WESTERN; CATTLE; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PROTEIN SUBUNITS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SUIPOXVIRUS; SWINE; T-LYMPHOCYTES;

BOVINAE; POXVIRIDAE; SUIDAE; SUS SCROFA;

EID: 0037191058     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(02)00205-2     Document Type: Article

References (33)

1. Bautista E.M., Molitor T. IFN-γ inhibits porcine reproductive and respiratory syndrome virus replication in macrophages. Arch. Virol. 144:1999;1-10.
2. Canals A., Gasbarre L.C., Boyd P.C., Almeria S., Zarlenga D.S. Cloning and expression of bovine interleukin-15: analysis and modulation of transcription by exogenous stimulation. J. Interferon Cytokine Res. 17:1997;473-480.
3. Chang J.T., Segal B., Nakanishi K., Okamura H., Shevach E.M. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit. Eur. J. Immunol. 30:2000;1113-1119.
4. Charley B., McCullough K., Martinod S. Antiviral and antigenic properties of recombinant interferon gamma. Vet. Immunol. Immunopathol. 19:1988;95-103.
5. Cho D., Lee W., Halloran P., Trinchieri G., Kim Y. Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cell. Immunol. 172:1996;29-34.
6. Collins R.A., Camon E.B., Chaplin P.J., Howard C.J. Influence of IL-12 on interferon-γ production by bovine leucocyte subsets in response to bovine respiratory syncitial virus. Vet. Immunol. Immunopathol. 63:1998;69-72.
7. Collins R.A., Howard C.J., Duggan S.E., Werling D. Bovine interleukin-12 and modulation of IFN-γ production. Vet. Immunol. Immunopathol. 68:1999;193-207.
8. Domeika K., Berg M., Eloranta M.L., Alm G.V. Porcine interleukin-12 fusion protein and interleukin-18 in combination induce interferon-gamma production in porcine natural killer cells and T cells. Vet. Immunol. Immunopahol. 86:2002;11-21.
9. Foss D.L., Moody M.D., Murphy K.P., Pazmany C., Zilliox M.J., Murtaugh M.P. In vitro and in vivo bioactivity of single chain interleukin-12. Scand. J. Immunol. 50:1999;596-604.
10. Gately, M.K., Chizzonite, R., 1992. Measurement of human and mouse interleukin-12. In: Coligan, J.E., Kruisbeek, A.M., Margulies, H.E., Shevach, E.M., Strober, W. (Eds.), Current Protocols in Immunology. Wiley, New York, pp. 6.16.1-5.
11. Gately M.K., Carvajal D.M., Connaughton S.E., Gillessen S., Warrier R.R., Kolinsky K.D., Wilkinson V.L., Dwyer C.M., Higgins G.F. Jr., Podlaski F.J., Faherty D.A., Familletti P.C., Stren A.S., Presky D.H. Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann. NY Acad. Sci. 795:1996;1-12.
12. Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U., Presky D.H. The interleukin-12/interleukin-12 receptor system: role in normal and pathologic immune response. Annu. Rev. Immunol. 16:1998;495-521.
13. Gazzinelli R.T., Hieny S., Wynn T.A., Wolf S., Sher A. IL-12 is required for the T-lymphocyte independent induction of interferon-gamma by an intracellular parasite and induces resistance in T cell-deficient hosts. Proc. Natl. Acad. Sci. U.S.A. 90:1993;6115-6119.
14. Heinzel F.P., Schoenhaut D.S., Rerko R.M., Rosser L.E., Gately M.K. Recombinant interleukin-12 cures mice infected with Leishmania major. J. Exp. Med. 177:1993;1505-1509.
15. -ΔΔCT method. Methods. 25:2001;402-408.
16. Mateu de Antonio E., Husmann R.J., Hansen R., Lunney J.K., Strom D., Martin S., Zuckermann F.A. Quantitative detection of porcine interferon-gamma in response to mitogen superantigen and recall viral antigen. Vet. Immunol. Immunopathol. 27:1998;265-277.
17. Morris S.C., Madden K.B., Adamovicz J.J., Gause W.C., Hubbard B.R., Gately M.K., Finkelman F.D. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1994;1047-1056.
18. Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.Y., Gately M.K., Gubler U. A functional interleukin-12 receptor is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 93:1996;14002-14007.
19. Presky D.H., Minetti L.J., Gillessen S., Wilkinson V.L., Wu C.Y., Gubler U., Chizzonite R., Gately M.K. Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J. Immunol. 160:1998;2174-2179.
20. Rogge L., Barberis Maino L., Biffi M., Passini N., Presky D.H., Gubler U., Sinigaglia F. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:1997;825-831.
21. Solano-Aguilar G.I., Vengroski K., Beshah E., Lunney J.K. Isolation and purification of lymphocyte subsets from gut associated lymphoid tissue in neonatal swine. J. Immun. Meth. 241:2000;185-199.
22. Solano-Aguilar G.I., Beshah E., Vengroski K.G., Zarlenga D., Jauregui L., Cosio M., Douglass L.W., Dubey J.P., Lunney J.K. Cytokine and lymphocyte profile after Toxoplasma gondii infection in miniature swine. Int. J. Parasitol. 31:2001;187-195.
23. Szabo S., Dighe A.S., Gubler U., Murphy K.M. Regulation of the interleukin IL-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:1997;817-824.
24. Thompson J.D., Higgins D.G., Gibson T.G. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucl. Acids Res. 22:1994;4673-4680.
25. Towbin, H.T., Staehelin, Gordon, J., 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76, 4350-4354.
26. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen specific adaptive immunity. Ann. Rev. Immunol. 13:1995;251-276.
27. Trinchieri G., Scott P. Interleukin-12: a proinflammatory cytokine wiyh immunoregulatory functions. Res. Immunol. 146:1995;423-431.
28. Trinchieri G., Scott P. Interleukin-12: basic principles and clinical applications. Curr. Top. Microbiol. Immunol. 238:1999;57-78.
29. Vandenbroeck K., Nauwynck H., Vanderpooten A., Van Reeth K., Goddeeris B., Billiau A. Recombinant porcine IFN-γ potentiates the secondary IgG and IgA responses to an inactivated Suid Herpesvirus-1 Vaccine and reduces post-challenge weight loss and fever in pigs. J. Interferon Cytokine Res. 18:1998;739-744.
30. Wu C.Y., Gadina M., Wang K., O'Shea J., Seder R.A. Cytokine regulation of IL-12 receptor β2 expression: differential effects on human T and NK cells. Eur. J. Immunol. 30:2000;1364-1374.
31. Zarlenga D.S., Canals A., Aschenbrenner R.A., Gasbarre L.C. Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin-12. Biochem. Biophys. Acta. 1270:1995;215-217.
32. Zarlenga D.S., Canals A., Gasbarre L.C. Methods for constructing internal standards for use in competitive PCR. Biotechniques. 19:1995;324-326.
33. Zuckermann F.A., Hussmann R., Brandt J., Mateu de Antonio E., Martin S. Interleukin-12 enhances the virus specific interferon gamma response of pigs to an inactivated Pseudorabies virus vaccine. Vet. Immun. Immunopathol. 63:1998;57-67.