Immunoglobulin heavy chain transgenic mice expressing Galα(1,3)Gal-reactive antibodies

Transplantation

Volumn 73, Issue 10, 2002, Pages 1558-1564

  Cretin, Nathalie ^a   Iacomini, John ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSYLGALACTOSE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSGENE; TRANSGENIC MOUSE;

EID: 0037182127     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200205270-00007     Document Type: Article

References (35)

1. Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in humans
2. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation
3. Anti-pig IgM antibodies in human serum react predominantly with Gal(α1-3)Gal epitopes
4. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells
5. One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody
6. Heterogeneity of human anti-pig natural antibodies cross-reactive with the Gal(α1,3)galactose epitope
7. Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora
8. Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces
9. Evaluation of the Gal α1-3Gal epitope as a host modification factor eliciting natural humoral immunity to enveloped viruses
10. Sensitization of cells and retroviruses to human serum by (α1-3)galactosyltransferase
11. Evolution and pathophysiology of the human natural anti-alpha-galactosyl IgG (anti-Gal) antibody
12. Oocyte Gal alpha 1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse
13. The alpha-1,3-galactosyltransferase knockout mouse: Implications for xenotransplantation
14. A sensitive assay for measuring alphaGal epitope expression on cells by a monoclonal anti-Gal antibody
15. Induction of B cell tolerance by retroviral gene therapy
16. Genes coding evolutionary novel anticarbohydrate antibodies: Studies on anti-Gal production in alpha 1,3 galactosyltransferase knock out mice
17. Introduction of a mu immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody
18. Immunoglobulin gene expression in transformed lymphoid cells
19. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens
20. Inhibition of xenoreactive natural antibody production by retroviral gene therapy
21. Human cell-mediated rejection of porcine xenografts in an immunodeficient mouse model
22. Monoclonal anti-allotype antibody towards BALB/c IgM: Analysis of specificity and site of a V-C crossover in recombinant strain BALB-Igh- Va/Igh-Cb
23. A monoclonal antibody against Igh6-4 determinant
24. Characteristics of immunoglobulin gene usage of the xenoantibody binding to Gal-alpha(1,3)Gal target antigens in the gal knockout mouse
25. Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout (GT-Ko) mice
26. Anti-galactose-alpha(1,3) galactose antibody production in alpha1,3-galactosyltransferase gene knockout mice after xeno and allo transplantation
27. Expression of Gal-alpha(1,3)Gal by porcine islet cells and its relevance to xenotransplantation
28. Pig islet xenografts are susceptible to "anti-pig" but not Galα(1,3)Gal antibody plus complement in Gal o/o mice
29. Induction of molecular chimerism by gene therapy prevents antibody mediated heart transplant rejection
30. Tolerization of anti-Galα1-3Gal natural antibody-forming B cells by induction of mixed chimerism
31. Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejection
32. In vivo T-cell depletion enhances production of anti-Galα1,3 Gal natural antibodies in α1,3-galactosyltransferase-deficient mice
33. The effect of an immunoglobulin mu transgene on B cell maturation
34. Transgenic mice and analysis of B-cell tolerance