Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in α1,3-galactosyltransferase knockout (GT-Ko) mice

Xenotransplantation

Volumn 7, Issue 4, 2000, Pages 275-283

  Chong, Anita S F ^a,b   Ma, Lianli ^a,b   Yin, Dengping ^a,b   Shen, Jikun ^a,b   Blinder, Leonard ^a,b   Xiulong, Xu ^a,b   Williams, James W ^a,b   Byrne, Gerry ^a,b   Diamond, Lisa E ^a,b   Logan, John S ^a,b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Nextran   (United States)

Author keywords

Anti 1,3galactose antibodies; Anti CD4; Galactosyltransferase; Mice; Rat; Xenoantibodies; Xenotranspl antation

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GALACTOSYLTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; OKT 4; OKT 8;

ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES; ANTIGENS, CD4; ANTIGENS, CD8; GALACTOSYLTRANSFERASES; GRAFT SURVIVAL; HEART TRANSPLANTATION; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED STRAINS; MICE, KNOCKOUT; RATS; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0033792447     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2000.00977.x     Document Type: Article

References (48)

1. Oocyte Galα1, 3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse
2. Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: A major obstacle for xenotransplantation in humans
3. One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody
4. Anti-pig IgM antibodies in human serum react predominantly with Gal (α1, 3) Gal epitopes
5. Galα (1, 3) Gal, the major xenoantigen (s) recognized in pigs by human natural antibodies
6. Human secretions contain IgA, IgG and IgM anti-Gal (anti-α-galactosyl) antibodies
7. Specificity and function of 'natural' antibodies in immunodeficient subjects: Clues to B cell lineage and development
8. Interaction between human natural anti-α-galactosyl immunoglobulin G and bacteria of the human flora
9. Characterization of human xenoreactive antibodies in liver failure patients exposed to pig hepatocytes after bioartificial liver treatment
10. The humoral immune response in humans following cross-perfusion of porcine organs
11. Increased anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters
12. Natural anti-Gal antibody as a universal augmenter of autologous tumor vaccine immunogenicity
13. Life supporting pig-to-baboon heart xenotransplantation
14. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage
15. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants
16. The α1, 3-galactosyltransferase knockout mouse. Implications for xenotransplantation
17. α1, 3-Galactosyltransferase-deficient mice produce naturally occurring cytotoxic anti-gal antibodies
18. Anti-Gal antibody-mediated allograft rejection in α1, 3-galactosyltransferase gene knockout mice
19. A murine model of antibody-mediated hyperacute rejection by galactose-α (1, 3) galactose antibodies in Gal o/o mice
20. Anti-Galactose-α (1,3) Galactose antibody production in α1, 3-galactosyltransferase gene knockout mice after xeno and allo transplantation
21. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8
22. Active suppression induced by anti-CD4
23. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies
24. Tolerance in the mouse major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8
25. 'Infectious' transplantation tolerance
26. Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients
27. Induction of tolerance to cardiac allografts
28. Mechanisms in CD4 antibody-mediated transplantation tolerance: Kinetics of induction, antigen dependency and role of regulatory T cells
29. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8
30. Kinetics of induction of transplantation tolerance with a nondepleting anti-CD4 monoclonal antibody and donor-specific transfusion before transplantation. A critical period of time is required for development of immunological unresponsiveness
31. How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
32. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-γ in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy
33. The Th1/Th2 paradigm and the allograft response
34. Cytokines and peripheral tolerance to alloantigen
35. Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model
36. Heterogeneity of human anti-pig natural antibodies cross-reactive with the Gal (α1, 3) Galactose epitope
37. Intermolecular cooperativity: A clue to why mice have IgG3?
38. Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces
39. The human antibody response to porcine xenoantigens is encoded by IGHV3-11 and IGHV3-74 IgVh germline progenitors
40. The relationship of IL-4, IL-10 and other cytokines to transplantation tolerance
41. α/β-T cell receptor-directed therapy in rat cardiac allograft recipients
42. An overview of the cytokines in transplantation
43. Cytokines and the Th1/Th2 paradigm in transplantation
44. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells
45. Induction of specific tolerance to allografts in rats by therapy with non-mitogenic, non-depleting anti-CD3 monoclonal antibody: Association with TH2 cytokines not anergy
46. Induction of tolerance with nondepleting anti-CD4 monoclonal antibodies is associated with down-regulation of TH2 cytokines
47. Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion
48. The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts