Central effects of 1,4-butanediol are mediated by GABAB receptors via its conversion into γ-hydroxybutyric acid

European Journal of Pharmacology

Volumn 441, Issue 3, 2002, Pages 157-163

  Carai, Mauro A M ^a   Colombo, Giancarlo ^b   Reali, Roberta ^a   Serra, Salvatore ^a   Mocci, Ignazia ^a   Castelli, M P ^a   Cignarella, Giorgio ^c   Gessa, Gian Luigi ^a,b  

^a Neuroscienze PharmaNess Scarl   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

1,4 Butanediol; 4 Methylpyrazole; CGP 46381; Disulfiram; Ethanol; GABAB receptor antagonist; GHB ( hydroxybutyric acid); GHB receptor antagonist; NCS 382; SCH 50911; Sedation hypnosis

Indexed keywords

(3 AMINOPROPYL)(CYCLOHEXYLMETHYL)PHOSPHINIC ACID; 1,4 BUTANEDIOL; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 HYDROXYBUTYRIC ACID; 4 METHYLPYRAZOLE; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; 6,7,8,9 TETRAHYDRO 5 HYDROXY 5H BENZOCYCLOHEPT 6 YLIDENEACETIC ACID; ACETIC ACID DERIVATIVE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE INHIBITOR; BACLOFEN; DISULFIRAM; ENZYME INHIBITOR; RECEPTOR; TRITIUM; UNCLASSIFIED DRUG; 1,4-BUTANEDIOL; 4-HYDROXYBUTYRIC ACID; BUTANEDIOL; HYDROXYBUTYRIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; HYPNOSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIGHTING REFLEX; SEDATION; ANIMAL; BRAIN CORTEX; COMPARATIVE STUDY; DBA MOUSE; DOSE RESPONSE; METABOLISM; PHYSIOLOGY; RAT; SLEEP; SPRAGUE DAWLEY RAT;

ANIMAL; BUTYLENE GLYCOLS; CEREBRAL CORTEX; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHANOL; HYDROXYBUTYRATES; MALE; MICE; MICE, INBRED DBA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; SLEEP; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0037177360     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01502-9     Document Type: Article

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