Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABA(B) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 13, 1996, Pages 1529-1534

  Blythin, David J ^a   Kuo, Shen Chun ^a   Shue, Ho Jane ^a   McPhail, Andrew T ^b   Chapman, Richard W ^a   Kreutner, William ^a   Rizzo, Charles ^a   She, Hoyan S ^a   West, Robert ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; ACETIC ACID DERIVATIVE; MORPHOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTICONVULSANT THERAPY; ARTICLE; DRUG SYNTHESIS; DRUG USE; ENANTIOMER; PETIT MAL; RESPIRATION DEPRESSION; X RAY ANALYSIS;

EID: 0030576292     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00267-3     Document Type: Article

References (15)

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15. min.(rel.) = 1.00:0.63] reflections with I>3.0σ(I). Atomic parameters, bond lengths, bond angles and torsion angles for 25 have been deposited at the Cambridge Crystallographic Data Center, 12 Union Road, Cambridge CB2 1EZ, U.K.