Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy

Neurology

Volumn 58, Issue 4, 2002, Pages 589-592

  Borghi, R ^a   Giliberto, L ^a   Assini, A ^a   Delacourte, A ^d   Perry, G ^c   Smith, M A ^c   Strocchi, P ^b   Zaccheo, D ^a   Tabaton, M ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN PROTEIN; CYCLIN DEPENDENT KINASE 5; PROTEIN KINASE; PROTEIN P35; PROTEIN SUBUNIT; REGULATOR PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; BRAIN LEVEL; BRAIN NERVE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NERVE FIBER GROWTH; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TISSUE DISTRIBUTION;

EID: 0037176843     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.58.4.589     Document Type: Article

References (22)

1. Neurodegenerative diseases with cytoskeletal pathology: A biochemical classification
2. Tau protein pathology in neurodegenerative diseases
3. Frontotemporal dementia and corticobasal degeneration in a family with a P301 mutation in tau
4. Tau gene mutation in familial progressive subcortical gliosis
5. Mutation in tau gene in familial multiple system tauopathy with presenile dementia
6. Direct genetic evidence for involvment of tau in progressive supranuclear palsy
7. Association of an extended haplotype in tau gene with progressive supranuclear palsy
8. Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy
9. Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy
10. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
11. Lipoperoxidation is selectively involved in progressive supranuclear palsy
12. The lipid peroxidation product 4-hydroxynonenal inhibits neurite, disrupts neuronal microtubules, and modifies cellular tubulin
13. 4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau
14. In Alzheimer's disease, heme oxygenase is coincident with ALZ50, an epitope of tau induced by 4-hydroxy-2-nonenal modification
15. Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal
16. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
17. Neurotoxicity induces cleavage of p35 to p25 by calpain
18. Validity and reliability of the preliminary NINDS neuropathologic criteria for progressive supranuclear palsy and related disorders
19. The Cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
20. Evidence for the participation of the neuron-specific Cdk5 activator p35 during laminin-enhanced axonal growth
21. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains
22. P25 protein in neurodegeneration