Intramolecular interaction of SUR2 subtypes for intracellular ADP-induced differential control of KATP channels

Circulation Research

Volumn 90, Issue 5, 2002, Pages 554-561

  Matsushita, Kenji ^a,b   Kinoshita, Kengo ^c   Matsuoka, Tetsuro ^a   Fujita, Akikazu ^a   Fujikado, Takashi ^b   Tano, Yasuo ^b   Nakamura, Haruki ^a   Kurachi, Yoshihisa ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Yokohama National University   (Japan)

Author keywords

Homology modeling; KATP channel; Nucleotide binding domain; Sulfonylurea receptor; Walker motif

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; NUCLEOTIDE BINDING PROTEIN; POTASSIUM CHANNEL; SULFONYLUREA RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CHIMERA; COMPLEX FORMATION; CONTROLLED STUDY; ELECTRICITY; ENZYME ACTIVATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; THREE DIMENSIONAL IMAGING;

ADENOSINE DIPHOSPHATE; ALTERNATIVE SPLICING; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; GENE EXPRESSION; HUMANS; INTRACELLULAR FLUID; KIDNEY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, DRUG; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0037155778     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000012666.42782.30     Document Type: Article

References (34)

1. Adenosine 5′-triphosphate-sensitive potassium channels
2. Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
3. ATP: An inward rectifier subunit plus the sulfonylurea receptor
4. + channels
5. + channel
6. + channel
7. Adenosine diphosphate as an intracellular regulator of insulin secretion
8. + channel currents expressed in Xenopus oocytes: A reinterpretation
9. The essential role of the Walker-A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide
10. ATP channel activity by diazoxide and MgADP. Distinct functions of the two-nucleotide binding folds of the sulfonylurea receptor
11. + channels by pinacidil and nicorandil
12. The ABC of channel regulation
13. Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters
14. 2+-independent ATP binding of the sulfonylurea receptor SUR1
15. Comparative aspects of the function and mechanism of SUR1 and MDR1 protein
16. ATP channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil
17. + channel
18. Crystal structure of the ATP-binding subunit of an ABC transporter
19. Comparative protein modelling by satisfaction of spatial restraints
20. PROCHECK: A program to check the stereochemical quality of protein structures
21. Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of archaeon Thermococcus litoralis
22. Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter
23. Affinity labeling of adenylate kinase with adenosine diphosphopyridoxal: Presence of Lys21 in ATP-binding site
24. Discrete mutations introduced in the predicted nucleotide binding sites of the mdr1 gene abolish its ability to confer multidrug resistance
25. Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP
26. + conductance
27. Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B
28. + channel with an ABC transporter
29. + channels
30. ATP channel inhibition by ATP
31. Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kit6.2
32. ATP channels: Control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit
33. ATP channel by ATP
34. ATP channel subunits