Thirty-six years in the clinic without an MMP inhibitor. What hath collagenase wrought?

Annals of the New York Academy of Sciences

Volumn 878, Issue , 1999, Pages 413-419

  Greenwald, Robert A ^a  

^a LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; MATRIX METALLOPROTEINASE INHIBITOR;

ANTIINFLAMMATORY ACTIVITY; CANCER; CONFERENCE PAPER; DRUG EFFICACY; OSTEOARTHRITIS; OSTEOPOROSIS; PERIODONTAL DISEASE; RHEUMATOID ARTHRITIS;

ANIMALIA; VERTEBRATA;

EID: 0032863894     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07699.x     Document Type: Conference Paper

References (6)

1. 1. Gross, J. & C. Lapiere. 1962. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc. Natl. Acad. Sci. USA 48: 1014-1022.
2. 2. Hirschmann, R. 1991. Medicinal chemistry in the gold age of biology: lessons from steroid and peptide research and review. Angew Chem. Int. Ed. Engl. 30: 1278-1301
3. 3. Greenwald, R.A. 1996. Monitoring collagen degradation in arthritic patients: the search for suitable surrogates. Arthritis and Rheumatism 39: 1455-1465
4. 4. Golub L.M, H.M. Lee, R.A. Greenwald et al. 1997. A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and bone-type collagenase in gingival crevicular fluid during adult periodontitis. Inflammation Res. 46: 310-319
5. 5. Greenwald, R.A. & K. Kirkwood. 1999. Adult periodontitis as a model for rheumatoid arthritis. J. Rheumatol. In press.
6. 6. Leung M., R.A. Greenwald, N.S. Ramamurthy et al. 1995. Effect of NSAIDs on the uptake of 4-dedimethylaminotetracycline and the inhibition of metalloproteinase activities in the inflamed joint of the adjuvant arthritic rat. J. Rheumatol. 22: 1726-1731.