Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria

European Journal of Pharmacology

Volumn 457, Issue 2-3, 2002, Pages 153-160

  Tan, Yean Yeow ^a   Dawson, Nicola F ^b   Kompa, Andrew R ^a   Bond, Courtney P ^a   Claasz, Antonia ^b   Wade, John D ^b   Tregear, Geoffrey W ^b   Summers, Roger J ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Atria; Chronotropic; Inotropic; INSL3 (Insulin like peptide 3); Rat; Receptor autoradiography; Relaxin

Indexed keywords

ARGININE DERIVATIVE; INSULIN LIKE FACTOR 3; ISOLEUCINE; ISOPRENALINE; PEPTIDE DERIVATIVE; RELAXIN; UNCLASSIFIED DRUG; VALINE; G PROTEIN COUPLED RECEPTOR; INSULIN; LEYDIG INSULIN LIKE PROTEIN; LEYDIG INSULIN-LIKE PROTEIN; PROTEIN; RECEPTOR; RECOMBINANT PROTEIN; RELAXIN RECEPTORS; RLN2 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BETA CHAIN; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HEART ATRIUM; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RAT; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; SHEEP; SPRAGUE DAWLEY RAT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; AUTORADIOGRAPHY; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; HEART ATRIA; HUMANS; INSULIN; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RECOMBINANT PROTEINS; RELAXIN; SHEEP;

EID: 0037146868     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02662-6     Document Type: Article

References (51)

1. Adham I.M., Burkhardt E., Benahmed M., Engel W. Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J. Biol. Chem. 268:1993;26668-26672.
2. Balvers M., Spiess A.-N., Domagalski R., Hunt N., Kilic E., Mukhopadhyay A.K., Hanks E., Charlton H.M., Ivell R. Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology. 139:1998;2960-2970.
3. Bathgate R., Balvers M., Hunt N., Ivell R. Relaxin-like factor gene is highly expressed in the bovine ovary of the cycle and pregnancy: sequence and messenger ribonucleic acid analysis. Biol. Reprod. 55:1996;1452-1457.
4. Bedarker S., Turnell W.G., Blundell T.L., Schwabe C. Relaxin has conformational homology with insulin. Nature. 270:1977;449-451.
5. Boockfor F.R., Fullbright G., Büllesbach E.E., Schwabe C. Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre- and neonatal development of rats. Reproduction. 122:2001;899-906.
6. Büllesbach E.E., Schwabe C. A novel leydig cell cDNA-derived protein is a relaxin-like factor. J. Biol. Chem. 270:1995;16011-16015.
7. Büllesbach E.E., Schwabe C. Tryptophan B27 in the relaxin-like factor (RLF) is crucial for RLF receptor-binding. Biochemistry. 38:1999;3073-3078.
8. Büllesbach E.E., Schwabe C. The relaxin receptor-binding site geometry suggests a novel gripping mode of interaction. J. Biol. Chem. 275:2000;35276-35280.
9. Büllesbach E.E., Yang S., Schwabe C. The receptor-binding site of human relaxin II: a dual prong-binding mechanism. J. Biol. Chem. 267:1992;22957-22960.
10. Büllesbach E.E., Rhodes R., Rembiesa B., Schwabe C. The relaxin-like factor is a hormone. Endocrine. 10:1999;167-169.
11. Burkhardt E., Adham I.M., Hobohm U., Murphy D., Sander C., Engel W. A human cDNA coding for the Leydig insulin-like peptide (Ley I-L). Hum. Genet. 94:1994;91-94.
12. 50) of an enzyme reaction. Biochem. Pharmacol. 22:1973;3099-3108.
13. Claasz A.A., Bathgate R.A., Dawson N.F., Summers R.J., Otvos L. Jr., Tregear G.W., Wade J.D. Chemical synthesis and relaxin activity of analogues of ovine Insulin 3 containing specific B-chain residue replacements. Tregear G.W., Ivell R., Bathdate R.A., Wade J.D. Relaxin 2000: Proceedings of the 3rd International Conference on Relaxin and Related Peptides. 2001;243-246 Kluwer Academic Publishers, The Netherlands.
14. Dawson N.F., Tan Y.Y., Macris M., Otvos L. Jr., Summers R.J., Tregear G.W., Wade J.D. Solid phase synthesis of ovine Leydig cell insulin-like peptide - a putative ovine relaxin? J. Pept. Res. 53:1999;542-547.
15. Dayanithi G., Cazalis M., Nordmann J.J. Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis. Nature. 325:1987;813-816.
16. Eigenbrot C., Randal M., Quan C., Burnier J., O'Connell L., Rinderknecht E., Kossiakoff A.A. X-ray structure of human relaxin at 1.5 Å: comparison to insulin and implications for receptor binding determinants. J. Mol. Biol. 221:1991;15-21.
17. 2-adrenoceptors of human heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 331:1985;60-70.
18. Gorlov I.P., Kamat A., Bogatcheva N.V., Jones E., Lamb D.J., Truong A., Bishop C.E., McElreavey K., Agoulnik A.I. Mutations of the GREAT gene cause cryptorchidism. Hum. Mol. Genet. 11:2002;2309-2318.
19. Hsu S.Y., Nakabayashi K., Nishi S., Kumagai J., Kudo M., Sherwood O.D., Hsueh A.J.W. Activation of orphan receptors by the hormone relaxin. Science. 295:2002;671-674.
20. Isaacs N., James R., Niall H., Bryant-Greenwood G., Dodson G., Evans A., North A.C.T. Relaxin and its structural relationship to insulin. Nature. 271:1978;278-281.
21. Ivell R., Balvers M., Domagalski R., Ungefroren H., Hunt N., Schulze W. Relaxin-like factor: a highly specific and constitutive new marker for Leydig cells in the human testis. Mol. Hum. Reprod. 3:1997;459-466.
22. Kakouris H., Eddie L.W., Summers R.J. Cardiac effects of relaxin in rats. Lancet. 339:1992;1076-1078.
23. Klonisch T., Ivell R., Balvers M., Kliesch S., Fischer B., Bergmann M., Steger K. Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia. Mol. Hum. Reprod. 5:1999;104-108.
24. Koskimies P., Virtanen H., Lindstrom M., Kaleva M., Poutanen M., Huhtaniemi I., Toppari J. A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism. Pediatr. Res. 47:2000;538-541.
25. Krausz C., Quintana-Murci L., Fellous M., Siffroi J.P., McElreavey K. Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism. Mol. Hum. Reprod. 6:2000;298-302.
26. Kumagai J., Hsu S.Y., Matsumi H., Roh J.-S., Fu P., Wade J.D., Bathgate R.A.D., Hsueh A.J.W. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J. Biol. Chem. 277:2002;31283-31286.
27. Lim H.N., Raipert-de Meyts E., Skakkebaek N.E., Hawkins J.R., Hughes I.A. Genetic analysis of the INSL3 gene in patients with maldescent of the testis. Eur. J. Endocrinol. 144:2001;129-137.
28. Marin P., Ferlin A., Moro E., Garolla A., Foresta C. Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism. J. Endocrinol. Investig. 24:2001;RC13-RC15.
29. Marin P., Ferlin A., Moro E., Rossi A., Bartoloni L., Rossato M., Foresta C. Novel insulin-like 3 (INSL3) gene mutation associated with human cryptorchidism. Am. J. Med. Genet. 103:2001;348-349.
30. McKinley M.J., Burns P., Colvill L.M., Oldfield B.J., Wade J.D., Weisinger R.S., Tregear G.W. Distribution of Fos immunoreactivity in the lamina terminalis and hypothalamus induced by centrally administered relaxin in conscious rats. J. Neuroendocrinol. 9:1997;431-437.
31. Mumford A.D., Parry L.J., Summerlee A.J.S. Lesion of the subfornical organ affects the heamotensive response to centrally administered relaxin in anaesthetised rats. J. Endocrinol. 122:1989;747-755.
32. Nef S., Parada L.F. Cryptorchidism in mice mutant for Insl3. Nat. Genet. 22:1999;295-299.
33. Osheroff P.L., Phillips H.S. Autoradiographic localization of relaxin binding sites in rat brain. Proc. Natl. Acad. Sci. U. S. A. 88:1991;6413-6417.
34. 33P-labeled human relaxin. Displaceable binding to rat uterus, cervix, and brain. J. Biol. Chem. 265:1990;9396-9401.
35. Overbeek P.A., Gorlov I.P., Sutherland R.W., Houston J.B., Harrison W.R., Boettger-Tong H.L., Bishop C.E., Agoulnik A.I. A transgenic insertion causing cryptorchidism in mice. Genesis. 30:2001;26-35.
36. Parry L.J., Poterski R.S., Summerlee A.J.S., Jones S.A. Mechanism of the heamotensive action of porcine relaxin in anaesthetised rats. J. Neuroendocrinol. 2:1990;53-58.
37. Pusch W., Balvers M., Ivell R. Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology. 137:1996;3009-3013.
38. Roche P.J., Crawford R.J., Tregear G.W. A single-copy relaxin-like gene sequence is present in sheep. Mol. Cell. Endocrinol. 91:1993;21-28.
39. Roche P.J., Butkus A., Wintour E.M., Tregear G.W. Structure and expression of Leydig insulin-like peptide mRNA in the sheep. Mol. Cell. Endocrinol. 121:1996;171-177.
40. Sherwood O.D. Relaxin in The Physiology of Reproduction. 2nd ed. 1994;Academic Press, New York.
41. Spiess A.-N., Balvers M., Tena-Sempere M., Huhtaniemi I., Parry L., Ivell R. Structure and expression of the rat relaxin-like factor (RLF) gene. Mol. Reprod. Dev. 54:1999;319-325.
42. Summerlee A.J., O'Byrne K.T., Paisley A.C., Breeze M.F., Porter D.G. Relaxin affects the central control of oxytocin release. Nature. 309:1984;372-374.
43. Tan Y.Y., Wade J.D., Tregear G.W., Summers R.J. Comparison of relaxin receptors in rat isolated atria and uterus by use of synthetic and native relaxin analogues. Br. J. Pharmacol. 123:1998;762-770.
44. Tan Y.Y., Wade J.D., Tregear G.W., Summers R.J. Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterisation and effects of oestrogen treatment. Br. J. Pharmacol. 127:1999;91-98.
45. Tashima L.S., Hieber A.D., Greenwood F.C., Bryant-Greenwood G.D. The human Leydig insulin-like (hLey I-L) gene is expressed in the corpus luteum and trophoblast. J. Clin. Endocrinol. Metab. 80:1995;707-710.
46. Tomboc M., Lee P.A., Mitwally M.F., Schneck F.X., Bellinger M., Witchel S.F. Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. J. Clin. Endocrinol. Metab. 85:2000;4013-4018.
47. Ward D.G., Thomas G.R., Cronin M.J. Relaxin increases rat heart rate by a direct action on the cardiac atrium. Biochem. Biophys. Res. Commun. 186:1992;999-1005.
48. Way S.A., Leng G. Relaxin increases the firing rate of supraoptic neurones and increases oxytocin secretion in the rat. J. Endocrinol. 132:1992;149-158.
49. Weisinger R.S., Burns P., Eddie L.W., Wintour E.M. Relaxin alters the plasma osmolality-arginine vasopressin relationship in the rat. J. Endocrinol. 137:1993;505-510.
50. Zimmermann S., Schöttler P., Engel W., Adham I.M. Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development. Mol. Reprod. Dev. 47:1997;30-38.
51. Zimmermann S., Steding G., Emmen J.M.A., Brinkmann A.O., Nayernia K., Holstein A.F., Engel E., Adham I.M. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13:1999;681-691.