A common polymorphism in the human relaxin-like factor (RLF) gene: No relationship with cryptorchidism

Pediatric Research

Volumn 47, Issue 4 I, 2000, Pages 538-541

  Koskimies, Pasi ^a   Virtanen, Helena ^a   Lindström, Magdalena ^a   Kaleva, Marko ^a   Poutanen, Matti ^a   Huhtaniemi, Ilpo ^a   Toppari, Jorma ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

RELAXIN;

ARTICLE; CHILD; CLINICAL ARTICLE; CRYPTORCHISM; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; INFANT; MALE; MALE INFERTILITY; NEWBORN; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SPERMATOGENESIS; TESTIS DESCENT;

EID: 0034074396     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200004000-00020     Document Type: Article

References (24)

1. Toppari J, Kaleva M 1999 Maldescendus testis. Horm Res 51:261-269
2. Giwercman A, Grindsted J, Hansen B, Jensen OM, Skakkebaek NE 1987 Testicular cancer risk in boys with maldescended testis: a cohort study. J Urol 138:1214-1216
3. Abyholm T, Oian P, Gordeladze JO 1986 True cryptorchidism and retractile testes in infertile men. Acta Eur Fertil 17:15-18
4. Carizza C, Antiba A, Palazzi J, Pistono C, Morana F, Alarcon M 1990 Testicular maldescent and infertility. Andrologia 22:285-288
5. Cendron M, Keating MA, Huff DS, Koop CE, Snyder III HM, Duckett JW 1989 Cryptorchidism, orchiopexy, and infertility: a critical long-term retrospective analysis. J Urol 142:559-62, 572
6. Lipschultz L, Caminos-Torres R, Greenspan C, Snyder P 1976 Testicular function after orchidopexy for unilaterally undescended testis. N Engl J Med 295:15-18
7. Lee P, O'Leary L, Songer N, Bellinger M, LaPorte R 1995 Paternity after cryptorchidism: lack of correlation with age at orchidopexy. Br J Urol 75:704-707
8. Weidner IS, Moller H, Jensen TK, Skakkebaek NE 1999 Risk factors for cryptorchidism and hypospadias. J Urol 161:1606-1609
9. Hjertkvist M, Damber JE, Bergh A 1989 Cryptorchidism: a registry-based study in Sweden on some factors of possible aetiological importance. J Epidemiol Community Health 43:324-329
10. Ivell R 1997 Biology of the relaxin-like factor (RLF). Rev Reprod 2:133-138
11. Burkhardt E, Adham IM, Hobohm U, Murphy D, Sander C, Engel W 1994 A human cDNA coding for the Leydig insulin-like peptide (Ley I-L). Hum Genet 94:91-94
12. Tashima LS, Hieber AD, Greenwood FC, Bryant-Greenwood GD 1995 The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast. J Clin Endocrinol Metab 80:707-710
13. Bullesbach EE, Schwabe C 1995 A novel Leydig cell cDNA-derived protein is a relaxin-like factor. J Biol Chem 270:16011-16015
14. Bullesbach EE, Rhodes R, Rembiesa B, Schwabe C 1999 The relaxin-like factor is a hormone. Endocrine 10:167-169
15. Bullesbach EE, Schwabe C 1999 Specific, high affinity relaxin-like factor receptors. J Biol Chem 274:22354-22358
16. Zimmermann S, Steding G, Emmen JM, Brinkmann AO, Nayernia K, Holstein AF, Engel W, Adham IM 1999 Targeted disruption of the Ins13 gene causes bilateral cryptorchidism. Mol Endocrinol 13:681-691
17. Nef S, Parada LF 1999 Cryptorchidism in mice mutant for Ins13. Nat Genet 22:295-299
18. Miller SA, Dykes DD, Polesky HF 1988 A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res 16:1215
19. Koskimies P, Spiess AN, Lahti P, Huhtaniemi I, Ivell R 1997 The mouse relaxin-like factor gene and its promoter are located within the 3′ region of the JAK3 genomic sequence. FEBS Lett 419:186-190
20. Zimmermann S, Schwarzler A, Buth S, Engel W, Adham IM 1998 Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1. Mol Endocrinol 12:706-713
21. Satokata I, Benson G, Maas R 1995 Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Nature 374:460-463
22. Rijli FM, Matyas R, Pellegrini M, Dierich A, Gruss P, Dolle P, Chambon P 1995 Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. Proc Natl Acad Sci USA 92:8185-8189
23. Kolon TF, Wiener JS, Lewitton M, Roth DR, Gonzales Jr ET, Lamb DJ 1999 Analysis of homeobox gene HOXA10 mutations in cryptorchidism. J Urol 161:275-280
24. Bullesbach EE, Schwabe C 1999 Tryptophan B27 in the relaxin-like factor (RLF) is crucial for RLF receptor-binding. Biochemistry 38:3073-3078