메뉴 건너뛰기




Volumn 123, Issue 4, 1998, Pages 762-770

Comparison of relaxin receptors in rat isolated atria and uterus by use of synthetic and native relaxin analogues

Author keywords

Functional receptor; Rat atria; Rat uterus; Relaxin; Signalling pathway

Indexed keywords

DRUG DERIVATIVE; G PROTEIN COUPLED RECEPTOR; RECEPTOR; RELAXIN; RELAXIN RECEPTORS;

EID: 0031988974     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701659     Document Type: Article
Times cited : (50)

References (59)
  • 1
    • 0025015701 scopus 로고
    • Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium
    • ANWER, K., HOVINGTON, J.A. & SANBORN, B.M. (1990). Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium. Biol. Reprod., 43, 851 - 859.
    • (1990) Biol. Reprod. , vol.43 , pp. 851-859
    • Anwer, K.1    Hovington, J.A.2    Sanborn, B.M.3
  • 2
    • 0017666678 scopus 로고
    • Relaxin has conformational homology with insulin
    • BEDARKER, S., TURNELL, W.G., BLUNDELL, T.L. & SCHWABE, C. (1977). Relaxin has conformational homology with insulin. Nature, 270, 449 - 451.
    • (1977) Nature , vol.270 , pp. 449-451
    • Bedarker, S.1    Turnell, W.G.2    Blundell, T.L.3    Schwabe, C.4
  • 4
    • 0025870325 scopus 로고
    • Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination
    • BÜLLESBACH, E.E. & SCHWABE, C. (1991). Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination, J. Biol. Chem., 266, 10754 - 10761.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10754-10761
    • Büllesbach, E.E.1    Schwabe, C.2
  • 5
    • 0029964784 scopus 로고    scopus 로고
    • The chemical synthesis of rat relaxin and the unexpectedly high potency of the synthetic hormone in the mouse
    • BÜLLESBACH, E.E. & SCHWABE, C (1996). The chemical synthesis of rat relaxin and the unexpectedly high potency of the synthetic hormone in the mouse. Eur. J. Biochem., 241, 533 - 537.
    • (1996) Eur. J. Biochem. , vol.241 , pp. 533-537
    • Büllesbach, E.E.1    Schwabe, C.2
  • 7
    • 0029764751 scopus 로고    scopus 로고
    • Chemical synthesis of a zwitterhormone, insulaxin, and of a relaxin-like bombyxin derivative
    • BÜLLESBACH, E.E., STEINETZ, B.G. & SCHWABE, C. (1996). Chemical synthesis of a zwitterhormone, insulaxin, and of a relaxin-like bombyxin derivative. Biochemistry, 35, 9754 - 9760.
    • (1996) Biochemistry , vol.35 , pp. 9754-9760
    • Büllesbach, E.E.1    Steinetz, B.G.2    Schwabe, C.3
  • 8
    • 0026497638 scopus 로고
    • The receptor-binding site of human relaxin II: A dual prong-binding mechanism
    • BÜLLESBACH, E.E., YANG, S. & SCHWABE, C. (1992). The receptor-binding site of human relaxin II: A dual prong-binding mechanism, J. Biol. Chem., 267, 22957 - 22960.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22957-22960
    • Büllesbach, E.E.1    Yang, S.2    Schwabe, C.3
  • 9
    • 0018875862 scopus 로고
    • 125I-labelled relaxin and tissue changes in adenosine 3′-5′-monophosphate levels after in vitro relaxin incubation
    • 125I-labelled relaxin and tissue changes in adenosine 3′-5′-monophosphate levels after in vitro relaxin incubation. Endocrinology, 106, 1203 - 1209.
    • (1980) Endocrinology , vol.106 , pp. 1203-1209
    • Cheah, S.H.1    Sherwood, O.D.2
  • 10
    • 0023150757 scopus 로고
    • Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis
    • DAYANITHI, G., CAZALIS, M & NORDMANN, J.J. (1987). Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis. Nature, 325, 813 - 816.
    • (1987) Nature , vol.325 , pp. 813-816
    • Dayanithi, G.1    Cazalis, M.2    Nordmann, J.J.3
  • 11
    • 0025815182 scopus 로고
    • Antagonism of relaxin by glibenclamide in the uterus of the rat in vivo
    • DOWNING, S.J. & HOLLINGSWORTH, M. (1991). Antagonism of relaxin by glibenclamide in the uterus of the rat in vivo. Br. J. Pharmacol., 104, 71 - 76.
    • (1991) Br. J. Pharmacol. , vol.104 , pp. 71-76
    • Downing, S.J.1    Hollingsworth, M.2
  • 12
    • 0027052313 scopus 로고
    • Cyclic adenosine 3′5′-monophosphate and the relaxant action of relaxin in the rat uterus in vivo
    • DOWNING, S.J., MCILWRATH, A. & HOLLINGSWORTH, M. (1992). Cyclic adenosine 3′5′-monophosphate and the relaxant action of relaxin in the rat uterus in vivo. J. Reprod. Fert., 96, 857 - 863.
    • (1992) J. Reprod. Fert. , vol.96 , pp. 857-863
    • Downing, S.J.1    Mcilwrath, A.2    Hollingsworth, M.3
  • 13
    • 0025812626 scopus 로고
    • X-ray structure of human relaxin at 1.5 Å: Comparison to insulin and implications for receptor binding determinants
    • EIGENBROT, C., RANDAL, M., QUAN, C., BURNIER, J., O'CONNELL, L., RINDERKNECHT, E & KOSSIAKOFF, A.A. (1991). X-ray structure of human relaxin at 1.5 Å: Comparison to insulin and implications for receptor binding determinants. J. Mol. Biol., 221, 15 - 21.
    • (1991) J. Mol. Biol. , vol.221 , pp. 15-21
    • Eigenbrot, C.1    Randal, M.2    Quan, C.3    Burnier, J.4    O'Connell, L.5    Rinderknecht, E.6    Kossiakoff, A.A.7
  • 14
    • 2442444878 scopus 로고
    • Isolation of relaxin from human placenta and its biological activity
    • ed. Bigazzi, M., Greenwood, F.C. & Gasparri, F. Amsterdam: Excerpta Medica
    • ENTENMANN, A.H., LIPPERT, T.H. & VOELTER, W. (1983). Isolation of relaxin from human placenta and its biological activity. In Biology of Relaxin and Its Role in the Human. ed. Bigazzi, M., Greenwood, F.C. & Gasparri, F. pp. 392 - 394. Amsterdam: Excerpta Medica.
    • (1983) Biology of Relaxin and Its Role in the Human , pp. 392-394
    • Entenmann, A.H.1    Lippert, T.H.2    Voelter, W.3
  • 15
    • 0028065936 scopus 로고
    • Characterisation of primate relaxin genes
    • EVANS, B.A., FU, P. & TREGEAR, G.W. (1994). Characterisation of primate relaxin genes. Endocr. J., 2, 81 - 86.
    • (1994) Endocr. J. , vol.2 , pp. 81-86
    • Evans, B.A.1    Fu, P.2    Tregear, G.W.3
  • 16
    • 0024351138 scopus 로고
    • The pharmacokinetics and pharmacodynamics of a human relaxin in the mouse pubic symphysis bioassay
    • FERRAIOLO, B.L., CRONIN, M., BAKHIT, C., ROTH, M., CHESTNUT, M. & LYON, R. (1989). The pharmacokinetics and pharmacodynamics of a human relaxin in the mouse pubic symphysis bioassay. Endocrinology, 125, 2922 - 2926.
    • (1989) Endocrinology , vol.125 , pp. 2922-2926
    • Ferraiolo, B.L.1    Cronin, M.2    Bakhit, C.3    Roth, M.4    Chestnut, M.5    Lyon, R.6
  • 19
    • 0022542171 scopus 로고
    • Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein
    • HAMILTON, T.C. WEIR, S.W. & WESTON, A.H. (1986). Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein. Br. J. Pharmacol., 88, 103 - 111.
    • (1986) Br. J. Pharmacol. , vol.88 , pp. 103-111
    • Hamilton, T.C.1    Weir, S.W.2    Weston, A.H.3
  • 20
    • 0028082029 scopus 로고
    • Relaxin increases heart rate by modulating calcium current in cardiac pacemaker cells
    • HAN, X., HABUCHI, Y. & GILES, W.R. (1994). Relaxin increases heart rate by modulating calcium current in cardiac pacemaker cells. Circ. Rex., 14, 537 - 541.
    • (1994) Circ. Rex. , vol.14 , pp. 537-541
    • Han, X.1    Habuchi, Y.2    Giles, W.R.3
  • 22
    • 0343629722 scopus 로고
    • Relaxin, a potassium channel opener in the isolated rat uterus?
    • HUGHES, S.J., DOWNING, S.J. & HOLLINGSWORTH, M. (1992). Relaxin, a potassium channel opener in the isolated rat uterus? Br. J. Pharmacol., 106, 80P.
    • (1992) Br. J. Pharmacol. , vol.106
    • Hughes, S.J.1    Downing, S.J.2    Hollingsworth, M.3
  • 24
    • 0018954893 scopus 로고
    • Modulation of cyclic AMP in isolated rat uterine slides by porcine relaxin
    • JUDSON, J.G., PAY, S & BHOOLA, K.D. (1980). Modulation of cyclic AMP in isolated rat uterine slides by porcine relaxin. J. Endocrinol., 87, 153 - 159.
    • (1980) J. Endocrinol. , vol.87 , pp. 153-159
    • Judson, J.G.1    Pay, S.2    Bhoola, K.D.3
  • 25
    • 0026608441 scopus 로고
    • Cardiac effects of relaxin in rats
    • KAKOURIS, H., EDDIE, L.W. & SUMMERS, R.J. (1992). Cardiac effects of relaxin in rats. Lancet, 339, 1076 - 1078.
    • (1992) Lancet , vol.339 , pp. 1076-1078
    • Kakouris, H.1    Eddie, L.W.2    Summers, R.J.3
  • 27
    • 0000418478 scopus 로고
    • The effects of estrogens, progestogens, and relaxin in pregnant and nonpregnant laboratory rodents
    • KROC, R.L., STEINETZ, B.G. & BEACH, V.L. (1959). The effects of estrogens, progestogens, and relaxin in pregnant and nonpregnant laboratory rodents. Ann. New York Acad. Sci., 75, 942 - 980.
    • (1959) Ann. New York Acad. Sci. , vol.75 , pp. 942-980
    • Kroc, R.L.1    Steinetz, B.G.2    Beach, V.L.3
  • 28
  • 30
    • 0030997318 scopus 로고    scopus 로고
    • Distribution of Fos immunoreactivity in the lamina terminalis and hypothalamus induced by centrally administered relaxin in conscious rats
    • MCKINLEY, M.J., BURNS, P., COLVILL, L.M., OLDFIELD, B.J., WADE, J.D., WEISINGER, R.S. & TREGEAR, G.W. (1997). Distribution of Fos immunoreactivity in the lamina terminalis and hypothalamus induced by centrally administered relaxin in conscious rats. J. Neuroendocrinol., 9, 431 - 437.
    • (1997) J. Neuroendocrinol. , vol.9 , pp. 431-437
    • Mckinley, M.J.1    Burns, P.2    Colvill, L.M.3    Oldfield, B.J.4    Wade, J.D.5    Weisinger, R.S.6    Tregear, G.W.7
  • 31
    • 0028861556 scopus 로고
    • Relaxin stimulates myometrial calcium-activated potassium channel activity via protein kinase A
    • Cell Physiol., 38
    • MEERA, P., ANWER, K., MONGA, M., OBERTI, C., STEFANI, E., TORO, L. & SANBORN, B.M. (1995). Relaxin stimulates myometrial calcium-activated potassium channel activity via protein kinase A. Am. J. Physiol., 269 (Cell Physiol., 38), C312 - 317.
    • (1995) Am. J. Physiol. , vol.269
    • Meera, P.1    Anwer, K.2    Monga, M.3    Oberti, C.4    Stefani, E.5    Toro, L.6    Sanborn, B.M.7
  • 32
    • 0024432107 scopus 로고
    • Lesion of the subfornical organ affects the heamolensive response to centrally administered relaxin in anaesthetised rats
    • MUMFORD, A.D., PARRY, L.J. & SUMMERLEE, A.J.S (1989). Lesion of the subfornical organ affects the heamolensive response to centrally administered relaxin in anaesthetised rats. J. Endocrinol., 122, 747 - 755.
    • (1989) J. Endocrinol. , vol.122 , pp. 747-755
    • Mumford, A.D.1    Parry, L.J.2    Summerlee, A.J.S.3
  • 33
    • 0026482651 scopus 로고
    • Potassium channel modulation in rat portal vein by ATP depletion: A comparison with the effects of levcromakalim (BRL 38227)
    • NOACK, T., DEITMER. P., EDWARDS, G. & WESTON, A.H (1992). Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br. J. Pharmacol., 107, 945 - 955.
    • (1992) Br. J. Pharmacol. , vol.107 , pp. 945-955
    • Noack, T.1    Deitmer, P.2    Edwards, G.3    Weston, A.H.4
  • 34
    • 0025718717 scopus 로고
    • Effects of porcine relaxin on contraction, membrane response and cyclic AMP content in rat myometrium in comparison with the effects of isoprenaline and forskolin
    • OSA, T., INOUE, H. & OKABE, K. (1991). Effects of porcine relaxin on contraction, membrane response and cyclic AMP content in rat myometrium in comparison with the effects of isoprenaline and forskolin. Br. J. Pharmacol., 104, 950 - 960.
    • (1991) Br. J. Pharmacol. , vol.104 , pp. 950-960
    • Osa, T.1    Inoue, H.2    Okabe, K.3
  • 36
    • 0026010298 scopus 로고
    • Autoradiographic localisation of relaxin binding sites in rat brain
    • OSHEROFF, P.L & PHILLIPS, H.S (1991). Autoradiographic localisation of relaxin binding sites in rat brain. Proc. Natl. Acad. Sci. U.S.A., 88, 6413 - 6417.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 6413-6417
    • Osheroff, P.L.1    Phillips, H.S.2
  • 37
    • 0025236675 scopus 로고
    • Mechanism of the heamotensive action of porcine relaxin in anaesthetised rats
    • PARRY, L.J., POTERSKI, R.S., SUMMERLEE, A.J.S. & JONES, S.A. (1990). Mechanism of the heamotensive action of porcine relaxin in anaesthetised rats. J. Neuroendocrinol., 2, 53 - 58.
    • (1990) J. Neuroendocrinol. , vol.2 , pp. 53-58
    • Parry, L.J.1    Poterski, R.S.2    Summerlee, A.J.S.3    Jones, S.A.4
  • 38
    • 33745401332 scopus 로고    scopus 로고
    • Effects of relaxin on rat atrial myocyles. I. Inhibition of Ito via PKA-dependent phosphorylation
    • PIEDRAS-RENTERÍA, E.S. SHERWOOD, O.D. & BEST, P.M (1997a). Effects of relaxin on rat atrial myocyles. I. Inhibition of Ito via PKA-dependent phosphorylation. Am. J. Physiol., 272, H1791 - H1797.
    • (1997) Am. J. Physiol. , vol.272
    • Piedras-Rentería, E.S.1    Sherwood, O.D.2    Best, P.M.3
  • 39
    • 0030988662 scopus 로고    scopus 로고
    • Effects of relaxin on rat atrial myocytes. II. Increased calcium influx derived from action potential prolongation
    • PIEDRAS-RENTERÍA, E.S., SHERWOOD, O.D & BEST, P.M. (1997b). Effects of relaxin on rat atrial myocytes. II. Increased calcium influx derived from action potential prolongation. Am. J. Physiol., 272, H1798 - H1803.
    • (1997) Am. J. Physiol. , vol.272
    • Piedras-Rentería, E.S.1    Sherwood, O.D.2    Best, P.M.3
  • 41
    • 0019401216 scopus 로고
    • Isolation and characterisation of relaxin from the sand tiger shark (Odontaspis taurus)
    • REINIG, J.W., DANIEL, L.N., SCHWABE, C., GOWAN, L.K., STEINETZ, B.G. & O'BYRNE, E.M. (1981). Isolation and characterisation of relaxin from the sand tiger shark (Odontaspis taurus). Endocrinology, 109, 537 - 543.
    • (1981) Endocrinology , vol.109 , pp. 537-543
    • Reinig, J.W.1    Daniel, L.N.2    Schwabe, C.3    Gowan, L.K.4    Steinetz, B.G.5    O'Byrne, E.M.6
  • 42
    • 2442464678 scopus 로고
    • The conserved basic residues in relaxin A chains are not required for biological activity Synthesis and properties of a telra-citrulline human relaxin II
    • REMBIESA, B., BRACEY, R. BÜLLESBACH, E.E & SCHWABE, C. (1993). The conserved basic residues in relaxin A chains are not required for biological activity Synthesis and properties of a telra-citrulline human relaxin II. Endocr. J., 1, 263 - 268.
    • (1993) Endocr. J. , vol.1 , pp. 263-268
    • Rembiesa, B.1    Bracey, R.2    Büllesbach, E.E.3    Schwabe, C.4
  • 43
    • 0018842127 scopus 로고
    • The interaction of relaxin on the rat uterus. I. Effect on cyclic nucleotide levels and spontaneous contractile activity
    • SANBORN, B.M., KUO, H.S. WEISBRODT, N.W & SHERWOOD, O.D. (1980). The interaction of relaxin on the rat uterus. I. Effect on cyclic nucleotide levels and spontaneous contractile activity. Endocrinology, 106, 1210 - 1215.
    • (1980) Endocrinology , vol.106 , pp. 1210-1215
    • Sanborn, B.M.1    Kuo, H.S.2    Weisbrodt, N.W.3    Sherwood, O.D.4
  • 44
    • 0024969417 scopus 로고
    • Cetacean relaxin. Isolation and sequence of relaxins from Balaenoptera acutorostrata and Balaenoptera edeni
    • SCHWABE, C., BÜLLESBACH, E.E. HEYN, H & YOSHIOKA, M. (1989). Cetacean relaxin. Isolation and sequence of relaxins from Balaenoptera acutorostrata and Balaenoptera edeni. J. Biol. Chem., 264, 940 - 943.
    • (1989) J. Biol. Chem. , vol.264 , pp. 940-943
    • Schwabe, C.1    Büllesbach, E.E.2    Heyn, H.3    Yoshioka, M.4
  • 45
    • 0018769393 scopus 로고
    • Purification and characterisation of rat relaxin
    • SHERWOOD, O.D. (1979). Purification and characterisation of rat relaxin. Endocrinology, 104, 886 - 892.
    • (1979) Endocrinology , vol.104 , pp. 886-892
    • Sherwood, O.D.1
  • 46
    • 0020017617 scopus 로고
    • Isolation and characterisation of porcine and rat relaxin
    • SHERWOOD, O.D. (1982). Isolation and characterisation of porcine and rat relaxin. Adv. Exp. Med. Biol., 143, 115 - 147.
    • (1982) Adv. Exp. Med. Biol. , vol.143 , pp. 115-147
    • Sherwood, O.D.1
  • 47
    • 0000563125 scopus 로고
    • Relaxin
    • ed. Knobil, E. & Neill, J.D. New York: Raven Press Ltd.
    • SHERWOOD, O.D. (1994). Relaxin. In The Physiology of Reproduction. 2nd Edition. ed. Knobil, E. & Neill, J.D. pp. 861 - 1009. New York: Raven Press Ltd.
    • (1994) The Physiology of Reproduction. 2nd Edition , pp. 861-1009
    • Sherwood, O.D.1
  • 48
    • 0010300347 scopus 로고
    • Bioassay of relaxin
    • ed. Dorfman, R.I. New York: Academic Press
    • STEINETZ, B.G., BEACH, V.L. & KROC, R.L. (1969). Bioassay of relaxin. In Methods in Hormone Research. ed. Dorfman, R.I. pp. 481 - 513. New York: Academic Press.
    • (1969) Methods in Hormone Research , pp. 481-513
    • Steinetz, B.G.1    Beach, V.L.2    Kroc, R.L.3
  • 49
    • 0026719752 scopus 로고
    • Purification and sequence determination of canine relaxin
    • STEWART, D.R., HENZEL, W.J. & VANDLEN, R. (1992). Purification and sequence determination of canine relaxin. J. Protein Chem., 11, 247 - 253.
    • (1992) J. Protein Chem. , vol.11 , pp. 247-253
    • Stewart, D.R.1    Henzel, W.J.2    Vandlen, R.3
  • 50
    • 0022479249 scopus 로고
    • Purification and characterisation of equine relaxin
    • STEWART, D.R. & PAPKOFF, H. (1986). Purification and characterisation of equine relaxin. Endocrinology, 119, 1093 - 1099.
    • (1986) Endocrinology , vol.119 , pp. 1093-1099
    • Stewart, D.R.1    Papkoff, H.2
  • 51
    • 0020414874 scopus 로고
    • Pharmacological studies on the action of relaxin upon KCI-contracted rat uterus
    • ST. LOUIS, J. (1982). Pharmacological studies on the action of relaxin upon KCI-contracted rat uterus. Pharmacology, 25, 327 - 337.
    • (1982) Pharmacology , vol.25 , pp. 327-337
    • St. Louis, J.1
  • 52
    • 0021829026 scopus 로고
    • Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats
    • ST. LOUIS, J. & MASSICOTTE, G. (1985). Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats. Life Sci, 37, 1351 - 1357.
    • (1985) Life Sci , vol.37 , pp. 1351-1357
    • St. Louis, J.1    Massicotte, G.2
  • 54
    • 0008004357 scopus 로고
    • Cardiac actions of relaxin
    • ed. MacLennan, A.M., Tregear, G.W. & Bryant-Greenwood, G.D. Singapore: Global Publications Services
    • SUMMERS, R.J., TAN, Y.Y., KAKOURIS, H. & EDDIE, L.W. (1995). Cardiac actions of relaxin. In Progress in Relaxin Research, ed. MacLennan, A.M., Tregear, G.W. & Bryant-Greenwood, G.D. pp. 487 - 498. Singapore: Global Publications Services.
    • (1995) Progress in Relaxin Research , pp. 487-498
    • Summers, R.J.1    Tan, Y.Y.2    Kakouris, H.3    Eddie, L.W.4
  • 58
    • 0026512506 scopus 로고
    • Relaxin increases the firing rate of supraoptic neurones and increases oxytocin secretion in the rat
    • WAY, S.A. & LENG, G (1992). Relaxin increases the firing rate of supraoptic neurones and increases oxytocin secretion in the rat. J. Endocrinol., 132, 149 - 158.
    • (1992) J. Endocrinol. , vol.132 , pp. 149-158
    • Way, S.A.1    Leng, G.2
  • 59
    • 0027249131 scopus 로고
    • Relaxin alters the plasma osmolality-arginine vasopressin relationship in the rat
    • WEISINGER, R.S., BURNS, P., EDDIE, L.W. & WINTOUR, E.M. (1993). Relaxin alters the plasma osmolality-arginine vasopressin relationship in the rat. J. Endotrinol., 137, 505 - 510.
    • (1993) J. Endotrinol. , vol.137 , pp. 505-510
    • Weisinger, R.S.1    Burns, P.2    Eddie, L.W.3    Wintour, E.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.