Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation

Biochemistry

Volumn 41, Issue 46, 2002, Pages 13556-13569

  De Filippis, Vincenzo ^a   Colombo, Giorgio ^b,c   Russo, Ilaria ^a   Spadari, Barbara ^a   Fontana, Angelo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COAGULANTS;

AMINO ACIDS; COMPUTER SIMULATION; ENZYMES; FREE ENERGY; HYDROPHOBICITY; MOLECULAR DYNAMICS; SUBSTRATES;

BIOCHEMISTRY;

ALANINE; ANTICOAGULANT AGENT; ANTITHROMBIN; BLOOD CLOTTING FACTOR 8; FIBRINOGEN; HIRUDIN; PROCOAGULANT; SODIUM ION; THROMBIN; THROMBIN INHIBITOR; THROMBIN RECEPTOR; TYROSINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BLOOD CLOTTING DISORDER; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG SCREENING; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS; SYNTHESIS;

AMINO ACIDS; ANTITHROMBINS; CIRCULAR DICHROISM; COMPUTER SIMULATION; HIRUDINS; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS; THROMBIN;

HOMO;

EID: 0037137217     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0203482     Document Type: Article

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