Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor

Protein Science

Volumn 8, Issue 10, 1999, Pages 2213-2217

  De Filippis, Vincenzo ^a   Russo, Ilaria ^a   Vindigni, Alessandro ^b   Di Cera, Enrico ^b   Salmaso, Stefano ^a   Fontana, Angelo ^a,c  

^a UNIVERSITY OF PADOVA   (Italy)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CRIBI Biotechnology Centre   (Italy)

Author keywords

Anticoagulant peptides; Hirudin; Noncoded amino acids; Peptide synthesis; Thrombin

Indexed keywords

AMINO ACID; BLOOD CLOTTING FACTOR 10A; HIRUDIN; PLASMIN; THROMBIN INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TRYPSIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN FOLDING;

HIRUDINIDA; HIRUDO MEDICINALIS;

EID: 0032833475     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.8.10.2213     Document Type: Article

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