Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids

Biochemistry

Volumn 37, Issue 39, 1998, Pages 13507-13515

  De Filippis, Vincenzo ^a   Quarzago, Daniela ^a   Vindigni, Alessandro ^b   Di Cera, Enrico ^b   Fontana, Angelo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; AMINO ACID; ANTICOAGULANT AGENT; ARGININE; CYSTEINE; DITHIOTHREITOL; HIRUDIN DERIVATIVE; MACROGOL 6000; PHENYL ISOTHIOCYANATE; PHENYLALANINE; PROCOAGULANT; SERINE; SYNTHETIC PEPTIDE; THROMBIN INHIBITOR; TRIFLUOROACETIC ACID; TYROSINE; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD CLOTTING; DISULFIDE BOND; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENTROPY; ENZYME INHIBITION; HYDROPHOBICITY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; CATTLE; CIRCULAR DICHROISM; GLYCINE; HIRUDINS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHENYLALANINE; SERINE; SPECTROMETRY, FLUORESCENCE; THROMBIN; TYROSINE; VALINE;

EID: 0032578491     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980717n     Document Type: Article

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