Iontophoresis of monomeric insulin analogues in vitro: Effects of insulin charge and skin pretreatment

Journal of Controlled Release

Volumn 51, Issue 1, 1998, Pages 47-56

  Langkjær, Lotte ^a   Brange, Jens ^a   Grodsky, Gerold M ^b   Guy, Richard H ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Insulin; Iontophoresis; Monomeric insulin analogues; Skin pretreatment; Transdermal delivery

Indexed keywords

ALCOHOL; INSULIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRIC RESISTANCE; IONTOPHORESIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN; SKIN CONDUCTANCE; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

2-PROPANOL; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; BIOLOGICAL TRANSPORT; ETHANOL; FEMALE; GALVANIC SKIN RESPONSE; HUMANS; INSULIN; IONTOPHORESIS; MICE; MICE, INBRED HRS; SKIN ABSORPTION; SOLVENTS;

EID: 0032559176     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00155-7     Document Type: Article

References (26)

1. Nathan D.M., Siebert C., Genuth S. DCCT: Design, outcome and implications. IDF Bull. 39(Suppl.):1994;5-10.
2. J. Brange, L. Langkjær, Insulin formulation and delivery, in: L.M. Sanders, R.W. Hendren (Eds.), Protein Delivery - Physical Systems, Plenum Publishing Corp., New York, NY, 1997, pp. 343-410.
3. Brange J., Ribel U., Hansen J.F., Dodson G., Hansen M.T., Havelund S., Melberg S.G., Norris F., Norris K., Snel L., Sørensen A.R., Voigt H.O. Monomeric insulins obtained by protein engineering and their medical implications. Nature. 333:1988;679-682.
4. Brange J., Owens D.R., Kang S., Vølund A. Monomeric insulins and their experimental and clinical implications. Diabetes Care. 13:1990;923-954.
5. Stephen R.L., Petelenz T.J., Jacobsen S.C. Potential novel methods for insulin administration: I. Iontophoresis. Biomed. Biochim. Acta. 43:1984;553-558.
6. Kari B. Control of blood glucose levels in alloxan-diabetic rabbits by iontophoresis of insulin. Diabetes. 35:1986;217-221.
7. Y.W. Chien, O. Siddiqui, Y. Sun, W.M. Shi, J.-C. Liu, Transdermal iontophoretic delivery of therapeutic peptides/proteins. I: Insulin, in: R.L. Juliano (Ed.), Biological Approaches to the Controlled Delivery of Drugs, Annals of the New York Academy of Sciences, vol. 507, The New York Academy of Sciences, New York, NY, 1987, pp. 32-50.
8. Siddiqui O., Sun Y., Liu J.-C., Chien Y.W. Facilitated transdermal transport of insulin. J. Pharm. Sci. 76:1987;341-345.
9. Liu J.-C., Sun Y., Siddiqui O., Chien Y.W., Shi W.M., Li J. Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin. Int. J. Pharm. 44:1988;197-204.
10. Meyer B.R., Katzeff H.L., Eschbach J.C., Trimmer J., Zacharias S.B., Rosen S., Sibalis D. Transdermal delivery of human insulin to albino rabbits using electrical current. Am. J. Med. Sci. 297:1989;321-325.
11. Banga A.K., Chien Y.W. Characterization of in vitro transdermal iontophoretic delivery of insulin. Drug Dev. Ind. Pharm. 19:1993;2069-2087.
12. B.H. Sage Jr., C.R. Bock, J.D. Denuzzio, R.A. Hoke, Technological and developmental issues of iontophoretic transport of peptide and protein drugs, in: V.H.L. Lee, M. Hashida, Y. Mizushima (Eds.), Trends and Future Perspectives in Peptide and Protein Drug Delivery, Harwood Academic Publishers, Chur, Switzerland, 1995, pp. 111-134.
13. B.H. Sage Jr., Insulin Iontophoresis, in: L.M. Sanders, R.W. Hendren (Eds.), Protein Delivery - Physical Systems, Plenum Publishing Corp., New York, NY, 1997, pp. 319-341.
14. 65Zn efflux from perifused islets Endocrinology. 117:1985;710-714.
15. Glikfeld P., Cullander C., Hinz R.S., Guy R.H. A new system for in vitro studies of iontophoresis. Pharm. Res. 5:1988;443-446.
16. Green P.G., Hinz R.S., Kim A., Szoka F.C., Guy R.H. Iontophoretic delivery of a series of tripeptides across the skin in vitro. Pharm. Res. 8:1991;1121-1127.
17. Banga A.K., Chien Y.W. Hydrogel-based iontotherapeutic delivery devices for transdermal delivery of peptide/protein drugs. Pharm. Res. 10:1993;697-702.
18. Reipa V., Gaigalas A., Abramowitz S. Conformational alterations of bovine insulin adsorbed on a silver electrode. J. Electroanal. Chem. 348:1993;413-428.
19. M.J. Pikal, Penetration enhancement of peptide and protein drugs by electrochemical means: Transdermal iontophoresis, in: V.H.L. Lee, M. Hashida, Y. Mizushima (Eds.), Trends and Future Perspectives in Peptide and Protein Drug Delivery, Harwood Academic Publishers GmbH., Chur, Switzerland, 1995, pp. 83-109.
20. Huang Y.-Y., Wu S.-M. Stability of peptides during iontophoretic transdermal delivery. Int. J. Pharm. 131:1996;19-23.
21. S. Havelund, personal communication.
22. J. Brange, B. Skelbaek-Pedersen, L. Langkjaer, U. Damgaard, H. Ege, S. Havelund, L.G. Heding, K.H. Jørgensen, J. Lykkeberg, J. Markussen, M. Pingel, E. Rasmussen, Galenics of Insulin. The Physico-chemical and Pharmaceutical Aspects of Insulin and Insulin Preparations, Springer-Verlag, Berlin, Heidelberg, New York, London, Paris, Tokyo, 1987.
23. Vølund Aa., Brange J., Drejer K., Jensen I., Markussen J., Ribel U., Sørensen A.R., Schlichtkrull J. In vitro and in vivo potency of insulin analogues designed for clinical use. Diabetic Med. 8:1991;839-847.
24. Srinivasan V., Higuchi W.I., Sims S.M., Ghanem A.H., Behl C.R. Transdermal iontophoretic drug delivery: Mechanistic analysis and application to polypeptide delivery. J. Pharm. Sci. 78:1989;370-375.
25. Srinivasan V., Su M.-H., Higuchi W.I., Behl C.R. Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin. J. Pharm. Sci. 79:1990;588-591.
26. van der Geest R., Hueber F., Szoka F. Jr., Guy R.H. Iontophoresis of bases, nucleosides, and nucleotides. Pharm. Res. 13:1996;553-558.