Synthesis of ortho-modified mercapto- and piperazino-methyl-phenylboronic acid derivatives

Tetrahedron

Volumn 58, Issue 8, 2002, Pages 1551-1556

  Spencer, John ^a,c   Burd, Andrew P ^a   Goodwin, Christopher A ^a   Mérette, Sandrine A M ^a   Scully, Michael F ^a   Adatia, Trushar ^b   Deadman, John J ^a  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b LONDON METROPOLITAN UNIVERSITY   (United Kingdom)

^c James Black Foundation   (United Kingdom)

Author keywords

Boron and compounds; Enzyme inhibitors; Piperazines; Thiols

Indexed keywords

1 METHYL 4 [2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYL]PIPERAZINE; 1 PHENYL 4 [2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYL]PIPERAZINE; 1 PYRIDIN 2 YL 4 [2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYL]PIPERAZINE; 2 [2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYLSULFANYL]PYRIDINE; 2 [2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYLSULFANYLMETHYL]NICOTINAMIDE; 2 [2 (BENZYLSULFANYLMETHYL)PHENYL] 4,4,5,5, TETRAMETHYL[1,3,2]DIOXABOROLANE; 2 [2 SEC BUTYLSULFANYLMETHYL)PHENYL 4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLANE; 2 [2 TERT BUTYLSULFANYLMETHYL)PHENYL] 4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLANE; 2 [4 (2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYL)PIPERAZIN 1 YL]PYRIMIDINE; 4 PYRIDIN 3 YL 2 [2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYLSULFANYL]PYRIMIDINE; 4,4,5,5 TETRAMETHYL 2 [2 (METHYLSULFANYLMETHYL)PHENYL][1,3,2]DIOXABOROLANE; 6 [4 METHYL 5 (2 (4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLAN 2 YL)BENZYLSULFANYL) 4H [1,2,4]TRIAZOL 3 YL]QUINOLINE; BORONIC ACID DERIVATIVE; ENZYME INHIBITOR; SERINE PROTEINASE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL; SOLID STATE; X RAY DIFFRACTION;

EID: 0037127860     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)01028-6     Document Type: Article

References (47)