Concise enantioselective synthesis of (+)-FR66979 and (+)-FR900482: Dimethyldioxirane-mediated construction of the hydroxylamine hemiketal

Angewandte Chemie - International Edition

Volumn 41, Issue 24, 2002, Pages 4683-4685

  Judd, Ted C ^a   Williams, Robert M ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Antitumor agents; Asymmetric synthesis; Hydroxylamines; Natural products; Total synthesis

Indexed keywords

ANTIBIOTICS; HYDROGEN BONDS; OXIDATION; SYNTHESIS (CHEMICAL); TUMORS;

ENANTIOSELECTIVE;

BIOCHEMISTRY;

4 FORMYL 6,9 DIHYDROXY 14 OXA 1,11 DIAZATETRACYCLO[7.4.1.0 2,7 0 10,12]TETRADECA 2,4,6 TRIEN 8 YLMETHYLCARBAMATE; ACETAL; AMINOKETONE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; DIMETHYLDIOXIRANE; EPOXIDE; FR 66979; HYDROXYLAMINE; OXAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; DEPROTECTION REACTION; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ISOMERISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; EPOXY COMPOUNDS; ISOMERISM; MOLECULAR STRUCTURE; OXAZINES;

EID: 0037122113     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200290015     Document Type: Article

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71. After submission of our manuscript, we recently learned that Professor Tohru Fukuyama and co-workers (Tokyo University) and Prof. Marco Ciufolini and co-workers (Université Claude Bernard Lyon 1) have independently completed syntheses of FR900482 and FR66979, respectively. We appreciate receiving preprints of their manuscripts. See the following communications: M. Suzuki, M. Kambe, H. Tokuyama, T. Fukuyama, Angew. Chem. 2002, 114, 4880; Angew. Chem. Int. Ed. 2002, 41, 4686; R. Ducray, M. A. Ciufolini, Angew. Chem. 2002, 114, 4882; Angew. Chem. Int. Ed. 2002, 41, 4688.
72. After submission of our manuscript, we recently learned that Professor Tohru Fukuyama and co-workers (Tokyo University) and Prof. Marco Ciufolini and co-workers (Université Claude Bernard Lyon 1) have independently completed syntheses of FR900482 and FR66979, respectively. We appreciate receiving preprints of their manuscripts. See the following communications: M. Suzuki, M. Kambe, H. Tokuyama, T. Fukuyama, Angew. Chem. 2002, 114, 4880; Angew. Chem. Int. Ed. 2002, 41, 4686; R. Ducray, M. A. Ciufolini, Angew. Chem. 2002, 114, 4882; Angew. Chem. Int. Ed. 2002, 41, 4688.
73. After submission of our manuscript, we recently learned that Professor Tohru Fukuyama and co-workers (Tokyo University) and Prof. Marco Ciufolini and co-workers (Université Claude Bernard Lyon 1) have independently completed syntheses of FR900482 and FR66979, respectively. We appreciate receiving preprints of their manuscripts. See the following communications: M. Suzuki, M. Kambe, H. Tokuyama, T. Fukuyama, Angew. Chem. 2002, 114, 4880; Angew. Chem. Int. Ed. 2002, 41, 4686; R. Ducray, M. A. Ciufolini, Angew. Chem. 2002, 114, 4882; Angew. Chem. Int. Ed. 2002, 41, 4688.