FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo

Chemistry and Biology

Volumn 7, Issue 10, 2000, Pages 805-812

  Beckerbauer, Lois ^a   Tepe, Jetze J ^b   Cullison, Jennifer ^a   Reeves, Raymond ^a   Williams, Robert M ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Anti tumor; DNA protein cross link; FR900482; High mobility protein; Mitomycin

Indexed keywords

4 FORMYL 6,9 DIHYDROXY 14 OXA 1,11 DIAZATETRACYCLO[7.4.1.0 2,7 0 10,12]TETRADECA 2,4,6 TRIEN 8 YLMETHYLCARBAMATE; ANTINEOPLASTIC AGENT; BINDING KINETICS; CHROMATIN; COVALENT BOND; CROSS LINKING; DNA BINDING; DNA FRAGMENT; IN VIVO STUDY; MITOMYCIN C; ONCOPROTEIN; POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; CELL DIVISION; CROSS-LINKING REAGENTS; DNA; DNA-BINDING PROTEINS; HIGH MOBILITY GROUP PROTEINS; HISTOCYTOCHEMISTRY; HMGA1A PROTEIN; HUMANS; JURKAT CELLS; MITOMYCIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NECROSIS; ONCOGENE PROTEINS; OXAZINES; PHOSPHOPROTEINS; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 0033772880     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00028-4     Document Type: Article

References (38)

1. HMG domain proteins: Architectural elements in the assembly of nucleoprotein complexes
2. High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function
3. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins
4. Complete murine cDNA sequence, genomic structure, and tissue expression of high mobility group protein HMG-I(Y)
5. Alternative processing of mRNAs encoding mammalian 'high mobility group' proteins HMG-I and HMG-Y
6. Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene
7. The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element
8. Isolation and characterization of the gene coding for murine high-mobility-group protein HMGI-C
9. The A-T-DNA-binding domain of mammalian high mobility group-I chromosomal proteins: A novel peptide motif for recognizing DNA structure
10. The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif
11. A poly(dA-dT) upstream activating sequence binds high- mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-β) gene regulation
12. The high mobility group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-βm gene
13. Mechanism of transcriptional synergism between distinct virus-inducible enhancer elements
14. Virus induction of human IFN-β expression requires the assembly of an enhanceosome
15. Regulation of cell type specific interleukin-2 receptor a chain gene expression: Potential role of physical interactions between Elf-1, HMG-I(Y) and NF-κB family proteins
16. High-mobility-group protein I(Y) is required for function and for c-Rel but not Rel A binding to CD28 response elements within the GM-CSF and IL-2 promoters
17. Cell cycle regulation and functions of HMG-I(Y)
18. High-mobility-group proteins and cancer-an emerging link
19. Chromosomal translocations in benign tumors: The HMG I proteins
20. HMG I(Y) and HMG I-C dysregulation: A common occurrence in human tumors
21. Determination of DNA cross-linking sequence specificity of FR66979: Observations on the mode of action of the FR900482 class of anti-tumor compounds
22. Covalent structure of the DNA-DNA interstrand cross-link formed by reductively actirated FR66979 in synthetic DNA duplexes
23. FR900482, a close cousin of mitomycin C that exploits mitosene-based cross-linking
24. Hypoxia-selective cytotoxins
25. Synthetic approaches toward FR900482. I. Stereoselective synthesis of a pentacyclic model compound
26. DNA-DNA interstrand cross-linking by FR66979 and FR900482: Requirement of metal ions during reductive activation
27. DNA-DNA interstrand cross-linking by FR66979: Intermediates in the activation cascade
28. Mitomycin C: Small, fast and deadly (but very selective)
29. FR66979 covalently cross-links the binding domain (BD) of the high mobility group I/Y (HMG I/Y) proteins to DNA
30. The role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation
31. Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction
32. Analysis of chromatin structure by in vivo formaldehyde cross-linking
33. Purification and assays for high mobility group HMG-I(Y) protein function
34. Alu repeats and human disease
35. African origin of human specific polymorphic Alu insertions
36. Effect of FK973, a new anti-tumor antibiotic, on the cell cycle of L1210 cells in vitro
37. A new anti-tumor antibiotic, FR900482. IV. Hematological toxicity in mice
38. A new anti-tumor antibiotic, FR900482 III. Anti-tumor activity in transplantable experimental tumors