DNA-DNA interstrand cross-linking by FR66979: Intermediates in the activation cascade

Journal of the American Chemical Society

Volumn 119, Issue 26, 1997, Pages 5999-6005

  Paz, Manuel M ^a   Hopkins, Paul B ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL 8ALPHA (CARBAMOYLOXYMETHYL) 3,9 EPOXY 5 FORMYL 1,1A,2,8,9,9A OCTAHYDROAZIRINO[2,3 C][1]BENZAZOCINE 7,9 DIOL ACETATE; 4 FORMYL 6,9 DIHYDROXY 14 OXA 1,11 DIAZATETRACYCLO[7.4.1.0 2,7 0 10,12]TETRADECA 2,4,6 TRIEN 8 YLMETHYLCARBAMATE; ANTINEOPLASTIC ANTIBIOTIC; BENZOXAZINE DERIVATIVE; FR 66979; MITOMYCIN C; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DNA CROSS LINKING; DNA DETERMINATION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 0030848358     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja970350u     Document Type: Article

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29. The presence of iron(II) was critical: FR66979 is essentially inert to treatment with sodium borohydride alone, as evidenced by the fact that this is one method of preparing FR66979 from FR900482.
30. This was confirmed by exposing freshly collected "13" from the HPLC to excess sodium borohydride, with the result that no 11 was produced.
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