Inhibition of autophagic proteolysis by inhibitors of phosphoinositide 3-kinase can interfere with the regulation of glycogen synthesis in isolated hepatocytes

Biochemical Journal

Volumn 368, Issue 3, 2002, Pages 827-833

  Dubbelhuis, Peter F ^a   Van Sluijters, Daphne A ^a   Blommaart, Edward F C ^a   Gustafson, Lori A ^a   Van Woerkom, George M ^a   Herling, Andreas W ^b   Burger, Hans Joerg ^b   Meijer, Alfred J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Cellular swelling; CP320626; LY294002; S4048; Wortmannin

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CHEMICAL ACTIVATION; GLUCOSE; SWELLING;

PROTEOLYSIS;

ENZYME INHIBITION;

2 MORPHOLINO 8 PHENYLCHROMONE; AMINO ACID DERIVATIVE; CP 320626; ENZYME INHIBITOR; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; LACTIC ACID; LEUCINE; PHENYLALANINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEINASE INHIBITOR; PYRUVIC ACID; S 4048; S6 KINASE; TYROSINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL ISOLATION; CELL SWELLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRADATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GLYCOGEN SYNTHESIS; GLYCOGENOLYSIS; GLYCOLYSIS; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; RAT; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; AMIDES; ANDROSTADIENES; ANIMALS; AUTOPHAGY; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCOSE; GLYCOGEN; HEPATOCYTES; IMIDAZOLES; INDOLES; INSULIN; LACTIC ACID; LEUCINE; MALE; MORPHOLINES; PHENYLALANINE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RATS; RATS, WISTAR; TYROSINE;

ANIMALIA;

EID: 0037115775     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021340     Document Type: Article

References (44)

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