Aberrant neuronal and paracellular deposition of endostatin in brains of patients with Alzheimer's disease

Journal of Neuroscience

Volumn 22, Issue 24, 2002, Pages 10621-10626

  Deininger, Martin H ^a   Fimmen, Birte A ^a   Thal, Dietmar R ^b   Schluesener, Hermann J ^a   Meyermann, Richard ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Alzheimer's disease; Amyloid; Deposits; Endostatin; Neurons

Indexed keywords

AMYLOID BETA PROTEIN; COLLAGEN; COLLAGEN TYPE 18; ENDOSTATIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANGIOGENESIS; APOPTOSIS; ARTICLE; BRAIN DISEASE; BRAIN HYPOXIA; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GLIOSIS; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR GROWTH; WESTERN BLOTTING;

EID: 0037114953     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-24-10621.2002     Document Type: Article

References (62)

1. Bayer TA, Fossgreen A, Czech C, Beyreuther K, Wiestler OD (1996) Plaque formation in brain transplants exposed to human beta-amyloid precursor protein 695. Acta Neuropathol Berl 92:130-137.
2. Bayer TA, Wirths O, Majtenyi K, Hartmann T, Multhaup G, Beyreuther K, Czech C (2001) Key factors in Alzheimer's disease: Beta-amyloid precursor protein processing, metabolism and intraneuronal transport. Brain Pathol 11:1-11.
3. Beyreuther K, Bush AI, Dyrks T, Hilbich C, Konig G, Monning U, Multhaup G, Prior R, Rumble B, Schubert W (1991) Mechanisms of amyloid deposition in Alzheimer's disease. Ann NY Acad Sci 640:129-139.
4. Bloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R, Werner S (2000) The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J 14:2373-2376.
5. Boehm T, Folkman J, Browder T, O'Reilly MS (1997) Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390:404-407.
6. Boehm T, O'Reilly MS, Keough K, Shiloach J, Shapiro R, Folkman J (1998) Zinc-binding of endostatin is essential for its antiangiogenic activity. Biochem Biophys Res Commun 252:190-194.
7. Braak H, Braak E (1991a) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol Berl 82:239-259.
8. Braak H, Braak E (1991b) Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol 1:213-216.
9. Brown WR, Moody DM, Thore CR, Challa VR (2000) Cerebrovascular pathology in Alzheimer's disease and leukoaraiosis. Ann NY Acad Sci 4:39-45.
10. Busciglio J, Lorenzo A, Yankner BA (1992) Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol Aging 13:609-612.
11. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95:11715-11720.
12. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
13. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell Jr PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE (1994) Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 7:180-184.
14. Deininger MH, Meyermann R (1998) Multiple epitope labeling by the exclusive use of alkaline phosphatase conjugates in immunohistochemistry. Histochem Cell Biol 110:425-430.
15. De Jong GI, De Vos RA, Steur EN, Luiten PG (1997) Cerebrovascular hypoperfusion: A risk factor for Alzheimer's disease? Animal model and postmortem human studies. Ann NY Acad Sci 826:56-74.
16. De la Torre JC (1997) Hemodynamic consequences of deformed microvessels in the brain in Alzheimer's disease. Ann NY Acad Sci 826:75-91.
17. Dhanabal M, Ramchandran R, Waterman MJ, Lu H, Knebelmann B, Segal M, Sukhatme VP (1999) Endostatin induces endothelial cell apoptosis. J Biol Chem 274:11721-11726.
18. Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC (1998) Zinc-dependent dimers observed in crystals of human endostatin. Proc Natl Acad Sci USA 95:10443-10448.
19. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152:307-317.
20. Galasko D, Chang L, Motter R, Clark CM, Kaye J, Knopman D, Thomas R, Kholodenko D, Schenk D, Lieberburg I, Miller B, Green R, Basherad R, Kertiles L, Boss MA, Seubert P (1998) High cerebrospinal fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol 55:937-945.
21. Glenner GG, Wong CW (1984) Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885-890.
22. Goedert M, Spillantini MG, Crowther RA (1991) Tau proteins and neurofibrillary degeneration. Brain Pathol 1:279-286.
23. Griffin WS, Sheng JG, Roberts GW, Mrak RE (1995) Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution. J Neuropathol Exp Neurol 54:276-281.
24. Griffin WS, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, Roberts GW, Mrak RE (1998) Glial-neuronal interactions in Alzheimer's disease: The potential role of a "cytokine cycle" in disease progression. Brain Pathol 8:65-72.
25. Hardy J (1994) ApoE, amyloid, and Alzheimer's disease. Science 263:454-455.
26. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (1998) Genetic dissection of Alzheimer's disease and related dementias: Amyloid and its relationship to tau. Nat Neurosci 1:355-358.
27. Hyman BT, Gomez-Isla T, Rebeck GW, Briggs M, Chung H, West HL, Greenberg S, Mui S, Nichols S, Wallace R, Growdon JH (1996) Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease. Ann NY Acad Sci 802:1-5.
28. Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, Fischer E, Younkin S, Borchelt DR, Hsiao KK, Carlson GA (1999) SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci 2:157-161.
29. Iqbal K, Braak E, Braak H, Zaidi T, Grundke-Iqbal I (1991) A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Neurobiol Aging 12:357-361.
30. John H, Preissner KT, Forssmann WG, Standker L (1999) Novel glycosylated forms of human plasma endostatin and circulating endostatin-related fragments of collagen XV. Biochemistry 38:10217-10224.
31. Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, Igeta Y, Ikeda Y, Amari M, Kawarabayashi T, Ishiguro K, et al. (1998) Longitudinal study of cerebrospinal fluid levels of tau, Aβ1-40, and Aβ1-42(43) in Alzheimer's disease: A study in Japan. Ann Neurol 44:17-26.
32. Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736.
33. Kawas CH, Brookmeyer R (2001) Aging and the public health effects of dementia. N Engl J Med 344:1160-1161.
34. Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 96:3922-3927.
35. Lan HY, Mu W, Ng YY, Nikolic-Paterson DJ, Atkins RC (1996) A simple, reliable, and sensitive method for nonradioactive in situ hybridization: Use of microwave heating to improve hybridization efficiency and preserve tissue morphology. J Histochem Cytochem 44:281-287.
36. Lowe J, Mayer RJ, Landon M (1993) Ubiquitin in neurodegenerative diseases. Brain Pathol 3:55-65.
37. Mandybur TI (1986) Cerebral amyloid angiopathy: The vascular pathology and complications. J Neuropathol Exp Neurol 45:79-90.
38. Masliah E, Cole G, Shimohama S, Hansen L, DeTeresa R, Terry RD, Saitoh T (1990) Differential involvement of protein kinase C isozymes in Alzheimer's disease. J Neurosci 10:2113-2124.
39. Masliah E, Mallory M, Hansen L, Alford M, Albright T, DeTeresa R, Terry R, Baudier J, Saitoh T (1991) Patterns of aberrant sprouting in Alzheimer's disease. Neuron 6:729-739.
40. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82:4245-4249.
41. Mates JM, Sanchez-Jimenez FM (2000) Role of reactive oxygen species in apoptosis: Implications for cancer therapy. Int J Biochem Cell Biol 32:157-170.
42. Mattiace LA, Davies P, Dickson DW (1990) Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol 136:1101-1114.
43. Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola S (1999) Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann NY Acad Sci 893:154-175.
44. McGeer PL, McGeer EG (1999) Inflammation of the brain in Alzheimer's disease: Implications for therapy. J Leukoc Biol 65:409-415.
45. Miosge N, Sasaki T, Timpl R (1999) Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls. FASEB J 13:1743-1750.
46. Mittelbronn M, Dietz K, Schluesener HJ, Meyermann R (2001) Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathol Berl 101:249-255.
47. Moody DM, Brown WR, Challa VR, Ghazi-Birry HS, Reboussin DM (1997) Cerebral microvascular alterations in aging, leukoaraiosis, and Alzheimer's disease. Ann NY Acad Sci 826:103-116.
48. Motter R, Vigo-Pelfrey C, Kholodenko D, Barbour R, Johnson-Wood K, Galasko D, Chang L, Miller B, Clark C, Green R (1995) Reduction of β-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 38:643-648.
49. Moulton KS, Heller E, Konerding MA, Flynn E, Palinski W, Folkman J (1999) Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation 99:1726-1732.
50. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J (1997) Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277-285.
51. Price JM, Sutton ET, Hellermann A, Thomas T (1997) Beta-Amyloid induces cerebrovascular endothelial dysfunction in the rat brain. Neurol Res 19:534-538.
52. Roses AD (1995) On the metabolism of apolipoprotein E and the Alzheimer diseases. Exp Neurol 132:149-156.
53. Schluesener HJ, Seid K, Zhao Y, Meyermann R (1997) Localization of endothelial-monocyte-activating polypeptide II (EMAP II), a novel proinflammatory cytokine, to lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis: Expression by monocytes and activated microglial cells. Glia 20:365-372.
54. Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD (1993) Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 90:9649-9653.
55. Strik HM, Schluesener HJ, Seid K, Meyermann R, Deininger MH (2001) Localization of endostatin in rat and human gliomas. Cancer 91:1013-1019.
56. Suh SW, Jensen KB, Jensen MS, Silva DS, Kesslak PJ, Danscher G, Frederickson CJ (2000) Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Res 852:274-278.
57. Takashima A, Noguchi K, Sato K, Hoshino T, Imahori K (1993) Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. Proc Natl Acad Sci USA 90:7789-7793.
58. Thal DR, Rueb U, Schultz C, Sassin I, Ghebremedhin E, Del Tredici K, Braak E, Braak H (2000) Sequence of Aβ-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol 59:733-748.
59. Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) Beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168-171.
60. Vinters HV, Wang ZZ, Secor DL (1996) Brain parenchymal and microvascular amyloid in Alzheimer's disease. Brain Pathol 6:179-195.
61. Wen W, Moses MA, Wiederschain D, Arbiser JL, Folkman J (1999) The generation of endostatin is mediated by elastase. Cancer Res 59:6052-6056.
62. Yamaguchi N, Anand-Apte B, Lee M, Sasaki T, Fukai N, Shapiro R, Que I, Lowik C, Timpl R, Olsen BR (1999) Endostatin inhibits VEGF- induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J 18:4414-4423.