Melanoma development and pigment cell transformation in Xiphophorus

Microscopy Research and Technique

Volumn 58, Issue 6, 2002, Pages 456-463

  Wellbrock, Claudia ^a   Gómez, Ana ^b   Schartl, Manfred ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b CSIC Instituto de Acuicultura de Torre de la Sal IATS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL SIGNALING; CELLS; CYTOLOGY; DERMATOLOGY; ENZYMES; MAMMALS; ONCOLOGY;

APOPTOTIC SIGNALING; CELL LINEAGE; CELL TRANSFORMATION; HYBRIDISATION; OVEREXPRESSIONS; RECEPTOR KINASE; RECEPTOR-TYROSINE KINASE; SIGNALING CASCADES; TUMOR INDUCTION; TUMOR PROGRESSIONS;

TUMORS;

MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; STAT5 PROTEIN; TYROSINE KINASE RECEPTOR;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINEAGE; CELL TRANSFORMATION; FISH; MELANOMA; NONHUMAN; PIGMENT CELL; PRIORITY JOURNAL; REVIEW; XIPHOPHORUS;

AVES; MAMMALIA; XIPHOPHORUS; XIPHOPHORUS HELLERII; XIPHOPHORUS MACULATUS;

EID: 0037106662     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10163     Document Type: Review

References (57)

1. Abe Y, Odaka M, Inagaki F, Lax I, Schlessinger J, Kohda D. 1998. Disulfide bond structure of human epidermal growth factor receptor. J Biol Chem 273:11150-11157.
2. Adam D, Wittbrodt J, Telling A, Schartl M. 1988. RFLP for an EGF-receptor related gene associated with the melanoma oncogene locus of Xiphophorus maculatus. Nucleic Acids Res 16:7212.
3. Adam D, Maueler W, Schartl M. 1991. Transcriptional activation of the melanoma inducing Xmrk oncogene in Xiphophorus. Oncogene 6:73-80.
4. Adam D, Dimitrijevic N, Schartl M. 1993. Tumor suppression in Xiphophorus by an accidentally acquired promoter. Science 259:816-819.
5. Ahuja MR, Anders F. 1976. A genetic concept of the origin of cancer, based in part upon studies of neoplasms in fishes. Prog Exp Tumor Res 20:380-397.
6. Anders F. 1991. Contributions of the Gordon-Kosswig melanoma system to the present concept of neoplasia. Pigment Cell Res 4:7-29.
7. Anders F, Diehl H, Schwab M, Anders A. 1979. Contributions to an understanding of the cellular origin of melanoma in the Gordon-Kosswig Xiphophorine fish tumor system. Pigment Cell 4:142-149.
8. Asai N, Iwashita T, Matsuyama M, Takahashi M. 1995. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 15:1613-1619.
9. Atz JW. 1962. Effects of hybridization on pigmentation in fishes of the genus Xiphophorus. Zoologica 47:153-181.
10. Barnekow A, Schartl M, Anders F, Bauer H. 1982. Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein. Cancer Res 42:2429-2433.
11. Batzer AG, Blaikie P, Nelson K, Schlessinger J, Margolis B. 1995. The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor. Mol Cell Biol 15:4403-4409.
12. Baudler M, Schartl M, Altschmied J. 1999. Specific activation of a STAT family member in Xiphophorus melanoma cells. Exp Cell Res 249:212-220.
13. Bohm M, Moellmann G, Cheng E, Alvarez-Franco M, Wagner S, Sassone-Corsi, P, Halaban R. 1995. Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes. Cell Growth Differ 6:291-302.
14. Bongarzone I, Vigano E, Alberti L, Mondellini P, Uggeri M, Pasini B, Borrello MG, Pierotti MA. 1999. The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein. Oncogene 18:4833-4838.
15. Breider H. 1952. Uber Melanosarkome, Melaninbildung und homologe Zellmechanismen. Strahlentherapie 88:619-639.
16. Burke CL, Stem DF. 1998. Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface. Mol Cell Biol 18:5371-5379.
17. Chappuis-Flament S, Pasini A, De Vita G, Segouffin-Cariou C, Fusco A, Attie T, Lenoir GM, Santoro M, Billaud M. 1998. Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines. Oncogene 17:2851-61.
18. Dimitrijevic N, Winkler C, Wellbrock C, Gomez A, Duschl J, A'tschmied J, Schartl M. 1998. Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations. Oncogene 16:1681-1690.
19. Gomez A, Wellbrock C, Gutbrod H, Dimitrijevic N, Schartl M. 2001. Ligand-independent dimerization and activation of the oncogenic xmrk receptor by two mutations in the extracellular domain. J Biol Chem 276:3333-3340.
20. Gordon M. 1927. The genetics of viviparous top-minnow Platypoecilus: the inheritance of two kinds of melanophores. Genetics 12:253-283.
21. Gordon M. 1931a. Hereditary basis of melanosis in hybrid fishes. Am J Cancer 15:1495-1519.
22. Gordon M. 1931b. Morphology of heritable color patterns in the Mexican killifish Platypoecilus. Am J Cancer 15:732-787.
23. Gordon M. 1948. Effects of five primary genes on the site of melanomas in fishes and the influence of two color genes on their pigmentation. In:The Biology of Melanomas. vol. 4. New York Academy of Science New York.
24. Gordon M. 1958 A genetic concept for the origin of melanomas. Ann NY Acad Sci 71:1213-1222.
25. Gutbrod H, Schartl M. 1999. Intragenic sex-chromosomal crossovers of Xmrk oncogene alleles affect pigment pattern formation and the severity of melanoma in Xiphophorus. Genetics 151:773-783.
26. Häussler G. 1928. Über Melanombildungen bei Bastarden von Xiphophorus maculatus var. rubra. Klin Wochenschr 7:1561-1562.
27. Kallman KD. 1970. Different genetic basis of identical pigment patterns in two populations of platyfish. Copeia 3:472-487.
28. Kallman KD. 1975. The platyfish, Xiphophorus maculatus. In: E. King, Editor. Handbook of genetics, vol. 4. New York: Plenum
29. Katz WS, Lesa GM, Yannoukakos D, Clandinin TR, Schlessinger J, Sternberg PW. 1996. A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol Cell Biol 16:529-537.
30. Kosswig C. 1928. Über Kreuzungen zwischen den Teleostiern Xiphophorus helleri und Platypoecilus maculatus. Z Indukt Abstammungs-Vererbungsl 47:150-158.
31. Kosswig C. 1929. Das Gen in fremder Erbmasse. Züchter 1:152-157.
32. Kosswig C. 1965. Genetische Grundlagen des Polymorphismus. Zool Anz 175:21-50.
33. Malitschek B, Wittbrodt J, Fischer P, Lammers R, Ullrich A, Schartl M. 1994. Autocrine stimulation of the Xmrk receptor tyrosine kinase in Xiphophorus melanoma cells and identification of a source for the physiological ligand. J Biol Chem 269:10423-10430.
34. Marshall CJ. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-85.
35. Morcinek JC, Weisser C, Geissinger E, Schartl M, Wellbrock C. 2002. Activation of STAT5 triggers proliferation and contributes to anti-apoptotic sigalling mediated by the oncogenic Xmrk kinase, Oncogene 21:1668-1678.
36. Pawson T. 1995. Protein modules and signalling networks. Nature 373:573-580.
37. Robertson SC, Meyer AN, Hart KC, Galvin BD, Webster MK, Donoghue DJ. 1998. Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain. Proc Natl Acad Sci USA 95:4567-4572.
38. Schartl M, Barnekow A, Bauer H, Anders F. 1982. Correlations of inheritance and expression between a tumor gene and the cellular homolog of the Rous sarcoma virus-transforming gene in Xiphophorus. Cancer Res 42:4222-4227.
39. Schartl M, Schmidt CR, Anders A, Barnekow A. 1985. Elevated expression of the cellular src gene in tumors of differing etiologies in Xiphophorus. Int J Cancer 36:199-207.
40. Schartl A, Malitschek B, Kazianis S, Borowsky R, Schartl M. 1995. Spontaneous melanoma formation in nonhybrid Xiphophorus. Cancer Res 55:159-165.
41. Siegel PM, Muller WJ. 1996. Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation. Proc Natl Acad Sci USA 93:8878-8883.
42. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, Neel BG, Birge RB, Fajardoj E, Chou MM, Hauafusa H, Schaffhausen B, Cantley LC. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767-778.
43. Sorokin A, Lemmon MA, Ullrich A, Schlessinger J. 1994. Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond. J Biol Chem 269:9752-9759.
44. Vogelstein B, Kinzler KW. 1993. The multistep nature of cancer. Trends Genet 9:138-141.
45. Webster MK, Donoghue DJ. 1997. FGFR activation in skeletal disorders: too much of a good thing. Trends Genet 13:178-182.
46. Wellbrock C, Schartl M. 1999. Multiple binding sites in the growth factor receptor Xmrk mediate binding to p59fyn, GRB2 and Shc. Eur J Biochem 260:275-283.
47. Wellbrock C, Schartl M. 2000. Activation of phosphatidylinositol 3-kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells. Eur J Biochem 267:3513-3522.
48. Wellbrock C, Lammers R, Ullrich A, Schartl M. 1995. Association between the melanoma-inducing receptor tyrosine kinase Xmrk and src family tyrosine kinases in Xiphophorus. Oncogene 10:2135-2143.
49. Wellbrock C, Gomez A, Schartl M. 1997. Signal transduction by the oncogenic receptor tyrosine kinase Xmrk in melanoma formation of Xiphophorus. Pigment Cell Res 10:34-40.
50. Wellbrock C, Fischer P, Schartl M. 1998a. Receptor tyrosine kinase Xmrk mediates proliferation in Xiphophorus melanoma cells. Int J Cancer 76:437-442.
51. Wellbrock C, Geissinger E, Gomez A, Fischer P, Friedrich K, Schartl M. 1998b. Signalling by the oncogenic receptor tyrosine kinase Xmrk leads to activation of STAT5 in Xiphophorus melanoma. Oncogene 16:3047-3056.
52. Wellbrock C, Fischer P, Schartl M. 1999. PI3-kinase is involved in mitogenic signaling by the oncogenic receptor tyrosine kinase Xiphophorus melanoma receptor kinase in fish melanoma. Exp Cell Res 251:340-349.
53. fyn leads to melanocyte dedifferentiation by influencing MKP-1 regulated MAP kinase signalling, J Biol Chem 277:6443-6454.
54. Winkler C, Wittbrodt J, Lammers R, Ullrich A, Schartl M. 1994. Ligand-dependent tumor induction in medakafish embryos by a Xmrk receptor tyrosine kinase transgene. Oncogene 9:1517-1525.
55. Wittbrodt J, Adam D, Malitschek B, Maueler W, Raulf F, Telling A, Robertson SM, Schartl M. 1989. Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature 341:415-421.
56. Wittbrodt J, Lammers R, Malitschek B, Ullrich A, Schartl M. 1992. The Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma. Embo J 11:4239-4246.
57. Zander CD. 1969. Uber die Entstehung und Veränderung von Farbmustern in der Gattung Xiphophorus (Pisces). Mitt Hamburg Zool Mus Inst 66:241-271.