The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein

Oncogene

Volumn 18, Issue 34, 1999, Pages 4833-4838

  Bongarzone, Italia ^a   Vigano, Elena ^a   Alberti, Luisella ^a   Mondellini, Piera ^a   Uggeri, Mauro ^a   Pasini, Barbara ^b   Borrello, Maria Grazia ^a   Pierotti, Marco A ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b Istituto Tumori   (Italy)

Author keywords

Dimerization; Oncogenic activation; RET

Indexed keywords

GLUTAMINE; LEUCINE; MEMBRANE RECEPTOR; MERCAPTOETHANOL; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CANCER GROWTH; CONTROLLED STUDY; DIMERIZATION; GENE ACTIVATION; GENE DELETION; GENE MUTATION; IMMUNOPRECIPITATION; METASTASIS; MISSENSE MUTATION; MOLECULAR GENETICS; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE RET; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

ANIMALIA;

EID: 0033607023     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202848     Document Type: Article

References (26)

1. Alexander WS, Metcalf D and Dunn AR. (1995). EMBO J., 14, 5569-5578.
2. Asai N, Iwashita T, Matsuyama M and Takahashi M. (1995). Mol. Cell. Biol., 15, 1613-1619.
3. Blaugrund JE, Johns MM, Eby JY, Ball DW, Baylin SB, Hruban RH and Sidransky D. (1994). Hum. Mol. Genet., 3, 1895-1897.
4. Bolino A, Schuffenecker I, Luo Y, Seri M, Silengo M, Tocco T, Chabrier G, Houdent C, Murat A, Schlumberger M, Towniaire J, Senoir GM and Omeo G. (1995). Oncogene, 10, 2415-2419.
5. Bongarzone I, Monzini N, Borrello MG, Carcano C, Ferraresi G, Arighi E, Mondellini P, Della Porta G and Pierotti MA. (1993). Mol. Cell. Biol., 13, 358-366.
6. Borrello MG, Alberti L, Arighi E, Bongarzone I, Battistini C, Bardelli A, Pasini B, Piutti C, Rizzetti MG, Mondellini P, Radice MT and Pierotti MA. (1996). Mol. Cell. Biol., 16, 2151-2163.
7. Carlson KM, Dou S, Chi D, Scavarda NJ, Toshima K, Jackson CE, Wells Jr SA, Goodfellow P and Donis-Keller H. (1994). Proc. Natl. Acad. Sci. USA, 91, 1579-1583.
8. Ceccherini I, Pasini B, Pacini F, Gullo M, Bongarzone I, Romei C, Santamaria G, Matera I, Mondellini P, Scopsi L, Pinchera A, Pierotti MA and Romeo G. (1997). Oncogene, 14, 2609-2612.
9. Chappuis-Flament S, Pasini A, De Vita G, Segouffin-Cariou C, Fusco A, Attie T, Lenoir GM, Santoro M and Billaud M (1998). Oncogene, 17, 2851-2861.
10. Donis-Keller H, Dou S, Chi D, Carlson KM, Toshima K, Lairmore TC, Howe JR, Moley JF, Goodfellow P and Wells Jr SA. (1993). Human Mol. Genet., 2, 851-856.
11. Eng C, Mulligan LM, Healey CS, Houghton C, Frilling A, Raue F, Thomas GA and Ponder BA. (1996). Cancer Res., 56, 2167-2170.
12. Eng C, Smith DP, Mulligan LM, Healey CS, Zvelebil MJ, Stonehouse TJ, Ponder MA, Jackson CE, Waterfield MD and Ponder BAJ. (1995a). Oncogene, 10, 509-513.
13. Eng C, Mulligan LM, Smith DP, Healey CS, Frilling A, Raue F, Neumann HPH, Pfragner R, Behmel A, Lorenzo MJ, Stonehouse TJ, Ponder MA and Ponder BAJ. (1995b). Genes Chrom. Cancer, 12, 209-212.
14. Eng C, Smith DP, Mulligan LM, Nagai MA, Healey CS, Ponder MA, Gardner E, Scheumann GFW, Jackson CE, Tunnacliffe A and Ponder BAJ. (1994). Human Mol. Genet., 3, 237-241.
15. Hofstra RM, Landsvater RM, Ceccherini I, Stulp RP, Stelwagen T, Luo Y, Pasini B, Hoppener JWM, Ploos van Hamstel HK, Romeo G, Lips CJM and Buys CHCM. (1994). Nature, 367, 375-376.
16. Hofstra RM, Stelwagen T, Stulp RP, De Jong D, Hulsbeek M, Kamsteeg EJ, van den Berg A, Landsvater RM, Vermey A, Molenaar WM, Lips CJ and Buys CH. (1996). J. Clin. Endocrin. Metabol., 81, 2881-2884.
17. Hoppner W and Ritter MM. (1997). Human Mol. Genet., 6, 587-590.
18. Isidoro C, Maggioni C, Demoz M, Pizzigalli A, Fra AM and Sitia R. (1996). J. Biol. Chem., 271, 26138-26142.
19. Kalinin V and Frilling A. (1998). J. Mol. Med., (in press).
20. Komminoth P, Kunz EK, Matias-Guiu X, Hiort O, Christiansen G, Colomer A, Roth J and Heitz PU. (1995). Cancer, 76, 479-489.
21. Lotti LV, Lanfrancone L, Igliaccio E, Ompetta C, Elicci G, Alcini AE, Alini B, Elicci PG and Orrisi MR. (1996). Mol. Cell. Biol., 16, 1946-1954.
22. Mulligan LM, Eng C, Attie T, Lyonnet S, Marsh DJ, Hyland VJ, Robinson BG, Frilling A, Verellen-Dumoulin C and Safar A. (1994). Human Molec. Genet., 3, 2163-2167.
23. Mulligan LM, Kwok JBJ, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papl L, Ponder MA, Telenlus H, Tunnacliffe A and Ponder BAJ. (1993). Nature, 363, 458-460.
24. Muragaki Y, Timothy N, Leight S, Hempstead BL, Chao MV, Trojanowski JQ and Lee VM. (1995). J. Comparat. Neurol., 356, 387-397.
25. Romei C, Elisei R, Pinchera A, Ceccherini I, Molinaro E, Mancusi F, Martino E, Romeo G and Pacini F. (1996). J. Clin. Endocrin. Metabol., 81, 1619-1622.
26. Siegel PM and Muller WJ. (1996). Proc. Natl. Acad. Sci. USA, 93, 8878-8883.