Cyclooxygenase-2 expression in endometrial carcinoma: Correlation with clinicopathologic parameters and clinical outcome

Cancer

Volumn 95, Issue 4, 2002, Pages 801-807

  Ferrandina, Gabriella ^a   Legge, Francesco ^a   Ranelletti, Franco O ^a   Zannoni, Gian F ^a   Maggiano, Nicola ^a   Evangelisti, Antonella ^a   Mancuso, Salvatore ^a   Scambia, Giovanni ^a   Lauriola, Libero ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Clinical outcome; Cyclooxygenase 2; Endometrial carcinoma; Prognostic factors; Treatment modalities

Indexed keywords

CYCLOOXYGENASE 2;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER STAGING; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADULT; AGED; CARCINOMA; CYCLOOXYGENASE 2; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MEMBRANE PROTEINS; MICROSATELLITE REPEATS; MIDDLE AGED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SURVIVAL ANALYSIS;

EID: 0037103036     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10736     Document Type: Article

References (39)

1. Cancer statistics, 1996
2. p53 expression in neoplasms of the uterine corpus
3. Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer
4. Microsatellite instability is an independent indicator of recurrence in sporadic stage I-II endometrial adenocarcinoma
5. Genetic instability of microsatellites in endometrial carcinoma
6. Prostaglandins endoperoxide synthase: Why two isoforms?
7. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2
8. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
9. Cyclooxygenase-2 regulates angiogenesis induced by colon cancer cells
10. Non small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: Up-regulation of interleukin 10 and down-regulation of interleukin 12 production
11. Cytoplasmic induction and overexpression of cyclooxygenase-2 in human prostate cancer: Implications for prevention and treatment
12. Cyclooxygenase-2 overexpression correlates with tumor recurrence, especially haematogenous metastasis of colorectal cancer
13. Depth of invasion parallels increased cyclooxygenase 2 levels in patients with gastric carcinoma
14. Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and poor survival in cervical cancer patients
15. Reduced COX-2 protein in colorectal cancer with defective mismatch repair
16. Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability
17. Cyclooxygenase-2 expression in normal endometrium, endometrial hyperplasia, and carcinoma
18. Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-δ in human endometrial adenocarcinoma
19. Nonparametric estimation from incomplete observations
20. Evaluation of survival data and two new rank order statistics arising in its consideration
21. Dangers of using "optimal" cut points in the evaluation of prognostic factors
22. Regression models and life tables
23. Expression of cyclooxygenase-2 in endometrial cancer in vivo
24. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas
25. Localization of cyclooxygenase-2 in human sporadic colorectal adenomas
26. Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma
27. Cyclooxygenase-2 is overexpressed in human cervical cancer
28. K-ras-mediated increase in cyclooxygenase-2 mRNA stability involves activation of the protein kinase B1
29. Expression of ras p21 oncoprotein in normal and neoplastic human endometrium
30. High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion
31. The relationship between cyclooxygenase-2 expression and colorectal cancer
32. Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma
33. Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy
34. A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability
35. Causes and consequences of microsatellite instability in endometrial carcinoma
36. Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer
37. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis