Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 49, Issue 5, 2001, Pages 1213-1217

  Gaffney, David K ^a   Holden, Joseph ^a   Davis, Marie ^a   Zempolich, Karen ^a   Murphy, Kelley J ^b   Dodson, Mark ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Cervix cancer; COX 2; Radiation therapy; Survival

Indexed keywords

FORMALDEHYDE; GENES; HEMOGLOBIN; PATIENT MONITORING; TUMORS;

CARCINOMAS;

RADIOTHERAPY;

CYCLOOXYGENASE 2; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); FORMALDEHYDE; HEMOGLOBIN; PARAFFIN; PROTEIN P53;

ADULT; AGED; ANGIOGENESIS; CANCER GRADING; CANCER INVASION; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CONFERENCE PAPER; CORRELATION FUNCTION; EARLY RESPONSE GENE; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RADIATION DOSE; STAINING; SURVIVAL RATE; TISSUE DISTRIBUTION; TUMOR BIOPSY; TUMOR VOLUME; UTERINE CERVIX CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CYCLOOXYGENASE 2; FEMALE; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SURVIVAL RATE; UTERINE CERVICAL NEOPLASMS;

EID: 0035312493     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01583-2     Document Type: Conference Paper

References (14)

1. High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion
2. Disease control of uterine cervical cancer; Relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy
3. Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone; Radiotherapeutic effect and prognosis
4. Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors
5. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug; Independence from COX-2 protein expression
6. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2
7. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
8. Enhancement of tumor response to gamma-radiation by an inhibitor of cyclooxygenase-2 enzyme
9. Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor
10. Host cyclooxygenase-2 modulates carcinoma growth
11. Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
12. Pathobiologic characteristics of hereditary breast cancer
13. Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells