The DC electrical-field-induced Ca2+ response and growth stimulation of multicellular tumor spheroids are mediated by ATP release and purinergic receptor stimulation

Journal of Cell Science

Volumn 115, Issue 16, 2002, Pages 3265-3273

  Sauer, Heinrich ^a   Stanelle, Ramona ^a   Hescheler, Jürgen ^a   Wartenberg, Maria ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Anion channel; ATP release; Electric field; Intracellular calcium; Multicellular tumor spheroid

Indexed keywords

5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; ADENOSINE TRIPHOSPHATE; ANION CHANNEL; APYRASE; CALCIUM ION; LUCIFERASE; LUCIFERIN; NIFLUMIC ACID; PROTEIN C FOS; PURINE RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SURAMIN; TAMOXIFEN; 5-NITRO-2-(3-PHENYLPROPYLAMINO)BENZOIC ACID; ANTINEOPLASTIC AGENT; CALCIUM; ION CHANNEL; NITROBENZOIC ACID DERIVATIVE;

AUTOCRINE EFFECT; BIOLUMINESCENCE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CANCER INHIBITION; CELL ACTIVITY; CELL SECRETION; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; DIRECT CURRENT; GENE ACTIVATION; GENE INACTIVATION; GROWTH STIMULATION; HUMAN; HUMAN CELL; MALE; MULTICELLULAR SPHEROID; PARACRINE SIGNALING; PRIORITY JOURNAL; PROSTATE TUMOR; PULSED ELECTRIC FIELD; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; TUMOR GROWTH; TUMOR SPHEROID; VELOCITY; ANIMAL; ARTICLE; CELL CULTURE; CELL DIVISION; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; ELECTRICITY; METABOLISM; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMAL; ANTINEOPLASTIC AGENTS; APYRASE; CALCIUM; CALCIUM SIGNALING; CELL DIVISION; ELECTRICITY; HUMAN; ION CHANNELS; MALE; MICROSCOPY, CONFOCAL; NIFLUMIC ACID; NITROBENZOATES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, PURINERGIC; SPHEROIDS; SURAMIN; TAMOXIFEN; TUMOR CELLS, CULTURED; ANIMALS; HUMANS; SPHEROIDS, CELLULAR;

EID: 0037101949     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (82)

1. Comparative pO2 measurements in cell spheroids cultured with different techniques
2. Overhead electricity power lines and childhood leukemia: A registry-based, case-control study
3. ATP crossing the cell plasma membrane generates an ionic current in xenopus oocytes
4. Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation
5. Environmental magnetic fields: Influences on early embryogenesis
6. Breast cancer and electromagnetic fields - A review
7. Different regulatory pathways involved in ATP-stimulated chloride secretion in rat epididymal epithelium
8. Regulation of C1-secretion by extracellular ATP in cultured mouse endometrial epithelium
9. Enhancement of fracture healing by specific pulsed capacitively-coupled electric field stimulation
10. Induced redistribution of cell surface receptors by alternating current electric fields
11. Reorganization of microfilament structure induced by ac electric fields
12. Transmembrane calcium influx induced by ac electric fields
13. Connexins regulate calcium signaling by controlling ATP release
14. The effect of electromagnetic field stimulation on corticosteroids-inhibited intestinal wound healing
15. Model for receptor-controlled cytosolic calcium oscillations and for external influences on the signal pathway
16. Model for external influences on cellular signal transduction pathways including cytosolic calcium Oscillations
17. Extracellular ATP: A growth factor for vascular smooth muscle cells
18. Migration of human keratinocytes in electric fields requires growth factors and extracellular calcium
19. DC electric fields induce rapid directional migration in cultured human corneal epithelial cells
20. Volume-sensitive purinergic signaling in human hepatocytes
21. Electric fields and proliferation in a chronic wound model
22. Extremely low frequency electromagnetic fields (EMF) and brain cancer in adults and children: Review and comment
23. Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia
24. Endogenous electrical currents and the resultant voltage gradients in the chick embryo
25. Alterations of intracellular calcium concentration in mice neuroblastoma cells by electrical field and UVA
26. P2Y receptors of MDCK cells: Epithelial cell regulation by extracellular nucleotides
27. The efficacy of ununited tibial fracture treatment using pulsing electromagnetic fields: Relation to biological activity on nonunion bone ends
28. Strong electrical currents leave the primitive streak of chick embryos
29. Electromagnetic fields: Low dose exposure, current update
30. Effects of extracellular nucleotides and nucleosides on prostate carcinoma cells
31. ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells
32. Calcium is necessary in the cell response to EM fields
33. Effects of the analytical treatment of exposure data on associations of cancer and occupational magnetic field exposure
34. The electrical stimulation of tibial osteotomies. Double-blind study
35. ATP-stimulated electrolyte and mucin secretion in the human intestinal goblet cell line HT29-C1.16E
36. Release of ATP by a human retinal pigment epithelial cell line: Potential for autocrine stimulation through subretinal space
37. A release mechanism for stored ATP in ocular ciliary epithelial cels
38. Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids
39. Polarity of isolated blastomeres from mouse morulae: Detection of transcellular ion currents
40. Protein kinases are required for embryonic neural crest cell galvanotaxis
41. Drug and radiation resistance in spheroids: Cell contact and kinetics
42. Detection of subpopulations resistant to DNA-damaging agents in spheroids and murine tumours
43. Electric field-directed cell shape changes, displacement, and cytoskeletal reorganization are calcium dependent
44. Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells
45. Cellular release of and response to ATP as key determinants of the set- point of signal transduction pathways
46. Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP
47. Purinergic receptors mediate cell proliferation and enhanced recovery from renal ischemia by adenosine triphosphate
48. 2+]i waves in prostatic cells
49. Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells
50. Calcium mobilization and cell proliferation activated by extracellular ATP in human ovarian tumour cels
51. Regulation of c-fos is affected by electromagnetic fields
52. Mortality patterns among electrical workers employed in the U.S. construction industry, 1982-1987
53. The responses of cells to electrical fields: A review
54. Self-generated electrical currents through Xenopus neurulae
55. - secretion in cultured human and rat biliary epithelial cells
56. Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability
57. Pulsed DC electric fields couple to natural NAD(P)H oscillations in HT-1080 fibrosarcoma cells
58. Volume-dependent atp-conductive large-conductance anion channel as a pathway for swelling-induced atp release
59. DC electrical field-induced c-fos expression and growth stimulation in multicellular prostate cancer spheroids
60. Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells
61. Increased doxorubicin uptake and toxicity in multicellular tumour spheroids treated with DC electrical fields
62. Mechanical strain-induced Ca(2+) waves are propagated via ATP release and purinergic receptor activation
63. Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
64. Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides
65. Extracellular ATP stimulates proliferation of cultured mesangial cells via P2-purinergic receptors
66. ATP release mechanism, ATP receptor and purinergic signalling along the nephron
67. Cell and environment interactions in tumor microregions: The multicell spheroid model
68. Population-based case-control study of occupational exposure to electromagnetic fields and breast cancer
69. ATP mediates calcium signaling between astrocytes and microglial cells: Modulation by IFN-gamma
70. Non-Hodgkin's lymphoma among electric utility workers in Ontario: The evaluation of alternate indices of exposure to 60 Hz electric and magnetic fields
71. Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth muscle cells
72. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation
73. 2+
74. Development of an intrinsic P-glycoprotein-mediated doxorubicin resistance in quiescent cell layers of large, multicellular prostate tumor spheroids
75. Growth stimulation versus induction of cell quiescence by hydrogen peroxide in prostate tumor spheroids is encoded by the duration of the Ca(2+) response
76. Redox regulation of P-glycoprotein-mediated multidrug resistance in multicellular prostate tumor spheroids
77. Detection of transcellular currents and effect of an imposed electric field on mouse blastomeres
78. ATP induces c-fos expression in C6 glioma cells by activation of P(2Y) receptors
79. Galvanotactic response of mouse epididymal sperm: In vitro effects of zinc and diethyldithiocarbamate
80. Directed migration of corneal epithelial sheets in physiological electric fields
81. A small, physiological electric field orients cell division
82. Electric field-directed cell motility involves up-regulated expression and asymmetric redistribution of the epidermal growth factor receptors and is enhanced by fibronectin and laminin