The Ly-6E.1 (Sca-1) gene requires a 3′ chromatin-dependent region for high-level γ-interferon-induced hematopoietic cell expression

Blood

Volumn 87, Issue 7, 1996, Pages 2750-2761

  Sinclair, A ^a   Daly, B ^a   Dzierzak, E ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; GLYCOPROTEIN; RECOMBINANT GAMMA INTERFERON; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FLANKING REGION; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, LY; BASE SEQUENCE; CELL DIFFERENTIATION; CHROMATIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIETIC STEM CELLS; INTERFERON TYPE II; MICE; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS;

EID: 0029998988     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.7.2750.bloodjournal8772750     Document Type: Article

References (49)

1. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58, 1988
2. Okada S, Nakauchi H, Nagayoshi K, Nishikawa S, Miura Y, Suda T: In vivo and in vitro stem cell function of c-kit and Sca-1 positive murine hematopoietic cells. Blood 80:3044, 1992
3. Khan KD, Lindwall G, Maher SE, Bothwell ALM: Characterization of promoter elements of an interferon-inducible Ly-6E/A differentiation antigen which is expressed on activated T cells and hematopoietic stem cells. Mol Cell Biol 10:5150, 1990
4. Sinclair AM, Dzierzak EA: Cloning of the complete Ly-6E.1 gene and identification of DNase 1 hypersensitive sites corresponding to expression in hematopoietic cells. Blood 82:3052, 1993
5. McGrew JT, Rock KL: Isolation, expression and sequence of the TAP/Ly-6A.2 chromosomal gene. J Immunol 146:3633, 1991
6. Stanford WL, Bruyns E, Snodgrass HR: The isolation and sequence of the chromosomal gene and regulatory regions of Ly-6A.2. Immunogenetics 35:408, 1992
7. LeClair KP, Palfree RGE, Flood PM, Hämmerling U, Bothwell A: Isolation of a murine Ly-6 cDNA reveals a new multigene family. EMBO J 5:3227, 1986
8. Kamiura S, Nolan CM, Meruelo D: Long range physical map of the Ly-6 complex: Mapping the Ly-6 multigene family by field-inversion and two dimensional gene electrophoresis. Genomics 12:89, 1992
9. Dumont FJ, Boltz RC: The augmentation of surface Ly-6A/E molecules in activated T cells is mediated by endogenous interferon-γ. J Immunol 139:4088, 1987
10. Dumont FJ, Coker LZ: Interferon-α/β enhances the expression of Ly-6 antigens on T cells in vivo and in vitro. Eur J Immunol 16:735, 1986
11. Dumont FJ, Palfree RGE, Coker LZ: Phenotypic changes induced by interferon in resting T cells: Major enhancement of Ly-6 antigen expression. J Immunol 137:201, 1986
12. Dumont FJ, Dijkmans R, Palfree RG, Bollz RD, Coker L: Selective up-regulation by interferon-gamma of surface molecules of the Ly-6 complex in resting T cells: The Ly-6A/E and TAP antigens are preferentially enhanced. Eur J Immunol 17:1183, 1987
13. Altmeyer A, Staruch MJ, Cofano F, Landolfo S, Dumont FJ: Multiple cytokine interactions regulate Ly-6E antigen expression: Cooperative Ly-6E induction by IFNs, TNF, and IL-1 in a T cell lymphoma and its induction-deficient variants. Cell Immunol 138:94, 1991
14. Malek TR, Danis KM, Codias EK: Tumor necrosis factor synergistically acts with IFN-gamma to regulate Ly-6A/E expression in T lymphocytes, thymocytes and bone marrow cells. J Immunol 142:1929, 1989
15. Li CL, Johnson GR: Rhodamine-123 reveals heterogeneity within murine Lin-, Sca-1+ hematopoietic stem cells. J Exp Med 175:1443, 1992
16. a haplotype. Blood 82:2673, 1993
17. Spangrude GJ, Brooks DM: Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells. Blood 82:3327, 1993
18. Van Zant G, Thompson BP, Chen JJ: Differentiation of chimeric bone marrow in vivo reveals genotype contributions to hematopoiesis. Exp Hematol 19:941, 1991
19. Phillips RL, Reinhart AJ, Van Zant G: Genetic control of murine hematopoietic stem cell pool sizes and cycling kinetics. Proc Natl Acad Sci USA 89:11607, 1992
20. Van Zant G, Scott-Micus K, Thompson BP, Fleischman RA, Perkins S: Stem cell quiescence/activation is reversible by serial transplantation and is independent of stromal cell genotype in mouse aggregation chimeras. Exp Hematol 20:470, 1992
21. Selden RF, Howie KB, Rowe ME, Goodman HM, Moore DD: Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol Cell Biol 6:3173, 1986
22. Khan KD, Shuai K, Lindwall G, Maher S, Darnell JE, Bothwell ALM: Induction of the Ly-6A/E gene by interferon αlβ and γ requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. Proc Natl Acad Sci USA 90:6806, 1993
23. Feeney A, Hämmerling U: Ala-1: A murine alloantigen of activated lymphocytes. Immunogenetics 3:369, 1976
24. Kimura S, Tada N, Liu-Lam Y, Hämmerling U: Studies of the mouse Ly-6 alloantigen system. II. Complexities of the Ly-6 region. Immunogenetics 20:47, 1984
25. Toulon M, Palfree RGE, Palfree S, Dumont FJ, Hämmerling U: Ly-6A/E antigen of murine T cells is associated with a distinct pathway of activation. Requirements for interferon and exogenous interleukin 2. Eur J Immunol 18:937, 1988
26. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Handbook (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Press, 1989
27. Pfeifer GP, Riggs AD: Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR. Genes Dev 5:1102, 1991
28. Shehee WR, Loeb DD, Adey NB, Burton FH, Casavant NC, Cole P, Davies CJ, McGraw RA, Schichman SA, Severynse DM, Voliva CF, Weyter FW, Wisely GB, Edgell MH, Huchison CA: Nucleotide sequence of the BALB/c mouse b-globin complex. J Mol Biol 205:41, 1989
29. Hug H, Costad M, Steheli P, Aebi M and Weissman C: Organization of the murine MX gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol 8:3065, 1988
30. Badiani P, Corbella P, Kioussis D, Marvel J, Weston K: Dominant interfering alleles define a role for c-myb in T cell development. Genes Dev 8:770, 1994
31. Gross DS, Garrard WT: Nuclease hypersensitive sites in chromatin. Ann Rev Biochem 57:159, 1988
32. Porter ACG, Chernajovski Y, Dale TC, Gilbert CS, Stark GR, Kerr IM: Interferon response element of the human gene 6-16. EMBO J 7:85, 1988
33. Reid LE, Brasnett AH, Gilbert CS, Porter ACG, Gewert DR, Stark GR, Kerr IM: A single DNA response element can confer inducibility by both α and β interferons. Proc Natl Acad Sci USA 86:840, 1989
34. Antoniou M, deBoer E, Habets G, Grosveld F: The human β globin gene contains multiple regulatory regions: Identification of one promoter and two downstream elements. EMBO J 7:377, 1988
35. Behringer RR, Hamer RE, Brinster RL, Palmiter RD, Townes TM: Two 3′ sequences direct adult erythroid-specific expression of human β-globin genes in transgenic mice. Proc Natl Acad Sci USA 84:7056, 1987
36. Bonifer C, Vidal M, Grosveld F, Sippel AE: Tissue specfic and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J 9:2843, 1990
37. Greaves DR, Wilson FD, Lang G, Kioussis D: Human CD2 3′ flanking sequences confer high-level, T cell-specific, position independent, gene expression in transgenic mice. Cell 56:979, 1989
38. Clevers H, Lonberg N, Dunlap S, Lacy E, Terhorst C: An enhancer located in a CpG-island 3′ to the TCR/CD3-ε gene confers T lymphocyte specificity to its promoter. EMBO J 8:2527, 1989
39. Leiden JM: Transcriptional regulation of T cell receptor genes. Annu Rev Immunol 11:539, 1993
40. Burn TC, Satterwaite AB, Tenen DG: The human CD34 hematopoietic stem cell antigen promoter and a 3′ enhancer direct hematopoietic expression in tissue culture. Blood 80:3052, 1992
41. May G, Enver T: Targeting gene expression to hematopoietic stem cells: A chromatin-dependent upstream element mediates cell type specific expression of stem cell antigen CD34. EMBO J 14:564, 1995
42. Brown J, Greaves MF, Molgaard HV: The gene encoding the stem cell antigen, CD34, is conserved in mouse and expressed in haemopoietic progenitor cell lines, brain and embryonic fibroblasts. Int Immunol 3:175, 1991
43. Reiser H, Coligan J, Palmer E, Benacerraf B, Rock KL: Cloning and expression of a cDNA for the T-cell-activating protein TAP. Proc Natl Acad Sci USA 85:2255, 1988
44. LeClair KP, Bridgett MM, Dumont FJ, Palfree RG, Hämmerling U, Bothwell AL: Kinetic analysis of Ly-6 gene induction in a T lymphoma by interferons and interleukin 1, and demonstration of Ly-6 inducibility in diverse cell types. Eur J Immunol 19:1233, 1989
45. Cray C, Keane RW, Malek TR, Levy RB: Regulation and selective expression of Ly-6A/E, a lymphocyte activation molecule, in the central nervous system. Brain Res Mol Brain Res 8:9, 1990
46. Baumheuter S, Singer SM, Henzel W, Hemmerich S, Renz M, Rosen SD, Lasky LA: Binding of L-selectin to the vascular sialomycin CD34. Science 262:436, 1993
47. Lee SK, Su B, Maher SE, Bothwell AL: Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. EMBO J 13:2167, 1994
48. Palfree RGE, LeClair KP, Bothwell A, Hämmerling U: cDNA characterization of an Ly-6.2 gene expressed in BW5147 tumor cells. Immunogenetics 26:389, 1987
49. Schmidt H, Gekeler V, Haas H, Engler-Blum G, Steiert I, Probst H, Müller CA: Differential regulation of HLA class I genes by interferon. Immunogenetics 31:245, 1990