Hyperekplexia mutation of glycine receptors: Decreased gating efficacy with altered binding thermodynamics

Biochemical Pharmacology

Volumn 64, Issue 2, 2002, Pages 285-288

  Maksay, Gábor ^a   Bíró, Tímea ^a   Laube, Bodo ^b  

^a CHEMICAL RESEARCH CENTER   (Hungary)

^b MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

Hyperekplexia mutation; Partial agonists; Recombinant glycine receptors; Strychnine; Taurine; Thermodynamics of binding

Indexed keywords

GLYCINE RECEPTOR; GLYCINE RECEPTOR AGONIST; GLYCINE RECEPTOR ANTAGONIST; PARTIAL AGONIST; RECEPTOR SUBTYPE; STRYCHNINE; TAURINE; TRITIUM;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; ENTHALPY; ENTROPY; HEAT; HUMAN; HUMAN CELL; INHIBITION KINETICS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TEMPERATURE DEPENDENCE; THERMODYNAMICS; VALIDATION PROCESS;

AMINO ACID MOTIFS; ARGININE; CELLS, CULTURED; GLYCINE; GLYCINE AGENTS; HUMANS; LEUCINE; MUTATION; RECEPTORS, GLYCINE; RECOMBINANT PROTEINS; STRYCHNINE; TAURINE; THERMODYNAMICS; TRANSFECTION;

EID: 0037099291     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01111-5     Document Type: Article

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