A decaepitope polypeptide primes for multiple CD8+ IFN-γ and Th lymphocyte responses: Evaluation of multiepitope polypeptides as a mode for vaccine delivery

Journal of Immunology

Volumn 168, Issue 12, 2002, Pages 6189-6198

  Alexander, Jeff ^a   Oseroff, Carla ^a   Dahlberg, Carol ^a   Qin, Mingsheng ^a   Ishioka, Glenn ^a   Beebe, Melanie ^a   Fikes, John ^a   Newman, Mark ^a   Chesnut, Robert W ^a   Morton, Phillip A ^a   Fok, Kam ^a   Appella, Ettore ^a   Sette, Alessandro ^a  

^a Epimmune   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; POLYPEPTIDE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENETIC MANIPULATION; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; SOLUBILIZATION; VACCINATION;

EID: 0037097764     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.12.6189     Document Type: Article

References (74)

1. Production of recombinant subunit vaccines: Protein immunogens, live delivery systems and nucleic acid vaccines
2. Design and production of recombinant subunit vaccines
3. Development of non-live vectors and procedures (liposomes, pseudo-viral particles, toxin, beads, adjuvants...) as tools for cancer vaccines
4. Tumor antigens recognized by T lymphocytes
5. Design and testing of peptide-based cytotoxic T-cell-mediated immunotherapeutic to treat infectious diseases and cancer
6. Immunopathogenesis of hepatitis B virus
7. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2
8. Qantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
9. + T cells associated with the control of infection
10. The biochemistry and cell biology of antigen processing and presentation
11. Assembly, transport and function of MHC class II molecules
12. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Down regulation by cytokines and bacterial products
13. Mechanisms of MHC class I-restricted antigen processing
14. Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages
15. Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: Pathway of presentation and regulation by cytokines
16. - T cell responses to infectious agents, tumors, transplants, and vaccines
17. Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages
18. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I molecules
19. + cytotoxic T lymphocyte responses in vivo
20. Priming of cytotoxic T lymphocytes by five heat-aggregated antigens in vivo: Conditions, efficiency, and relation to antibody responses
21. HBV core particles as a carrier for B cell/T cell epitopes
22. Generation of human cytolytic T lymphocyte lines directed against prostate-specific antigen (PSA) employing a PSA oligoepitope peptide
23. Extracellular processing and presentation of a 69-mer synthetic polypeptide to MHC class I-restricted T cells
24. Pools of lipidated HTL-CTL constructs prime for multiple HBV and HCV CTL epitope responses
25. + cytotoxic T cells: Implications for vaccine design
26. Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen
27. An HLA-A2 polyepitope vaccine for melanoma immunotherapy
28. Development, expression, and murine testing of a multistage Plasmodium falciparum malaria vaccine candidate
29. DNA immunization with minigenes: Low frequency of memory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination
30. Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine
31. Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes
32. Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1)
33. Toward a vaccine for AIDS: The emergence of immunobiology-based vaccine development
34. Hepatitis B surface antigen variation and protective immunity
35. Variability of hepatitis C virus
36. Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides
37. Efficient induction of melanoma reactive CTL with peptides modified at HLA-A*0201 binding residues from the melanoma antigen, gp100
38. Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines
39. Synthesis and immunological characterization of 104-mer and 102-mer peptides corresponding to the N- and C-terminal regions of the Plasmodium falciparum cs protein
40. Preclinical evaluation of an immunotherapeutic-peptide comprising 7 T-cell determinants of Cry J I and Cry j 2, the major Japanese cedar pollen allergens
41. Long synthetic peptides encompassing the Plasmodium falciparum LSA3 are the target of human B and T cells and are potent inducers of B helper, T helper and cytolytic T cell responses in mice
42. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex
43. b transgenic mice: Functional CTL repertoire and recognition of human A11-restricted CTL epitopes
44. Production of human cells expressing individual transferred HLA-A, -B, -C genes using an HLA-A, -B, -C null human cell line
45. Human histocompatibility leukocyte antigen-biding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis
46. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen
47. Characterization of HLA-A0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein
48. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis
49. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1
50. Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: Implications for vaccine development
51. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection
52. Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide
53. Characterization of an in situ IFN-γ ELISA assay which is able to detect specific peptide responses from freshly isolated splenocytes induced by DNA minigene immunization
54. Progenipoietins: Biological characterization of a family of dual agonists of fetal liver tyrosine kinase-3 and the granulocyte colony-stimulating factor receptor
55. Dendritic cells generated in vivo by a chimeric hematopoietic growth factor, progenipoietin-4, demonstrate potent immunological function
56. Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice
57. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules
58. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTL
59. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
60. + T-cell memory determined by clonal burst size
61. Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells
62. + T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
63. + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
64. Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS
65. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen
66. Assembly of synthetic peptide vaccines by chemoselective ligation of epitopes: Influence of different chemical linkages and epitope orientations on biological activity
67. Transgenic plants as factories for biopharmaceuticals
68. Applications of yeast in biotechnology: Protein production and genetic analysis
69. Glycoproteins from insect cells: Sialylated or not?
70. Tat-mediated delivery of heterologous proteins into cells
71. Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide
72. Delivery of antigens to the MHC class I pathway using bacterial toxins
73. + lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule Mamu-A*01: Implications for vaccine design and testing
74. Molecular determinants of peptide binding to two common rhesus macaque MHC class II molecules