Microsatellite analysis at 10q25-q26 in Sardinian patients with sporadic endometrial carcinoma: Identification of specific patterns of genetic alteration

Cancer

Volumn 89, Issue 8, 2000, Pages 1773-1782

  Palmieri, Giuseppe ^a   Manca, Antonella ^a   Cossu, Antonio ^b   Ruiu, Giovanni ^b   Pisano, Marina ^a   Cherchi, Pierluigi ^b   Dessole, Salvatore ^b   Pintus, Adriana ^b   Massarelli, Giovannino ^b   Tanda, Francesco ^b   Pirastu, Mario ^a  

^a CNR   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

And microsatellite instability (MSI); Chromosome 10q25 q26; Endometrial carcinoma (EC); Loss of heterozygosity (LOH); Polymerase chain reaction (PCR)

Indexed keywords

MICROSATELLITE DNA;

ADULT; ARTICLE; CANCER SCREENING; CHROMOSOMAL LOCALIZATION; CHROMOSOME 10Q; CHROMOSOME MAP; ENDOMETRIUM CANCER; FEMALE; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENOME; HUMAN; ITALY; MAJOR CLINICAL STUDY; PREVALENCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; DNA, NEOPLASM; ENDOMETRIAL NEOPLASMS; FEMALE; GENETIC MARKERS; HUMAN; ITALY; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MIDDLE AGE; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; SUPPORT, NON-U.S. GOV'T;

EID: 0034667652     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20001015)89:8<1773::AID-CNCR18>3.0.CO;2-H     Document Type: Article

References (47)

1. Endometrial carcinoma
2. Identification of a candidate tumor suppressor gene MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
3. PTEN, a putative protein tyrosinase phosphatase gene mutated in human brain, breast and prostate cancer
4. Involvement of p53 gene mutations in human endometrial carcinomas
5. PTEN1 is frequently mutated in primary endometrial carcinomas
6. Mutation in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
7. PTEN/NMAC1 mutations in endometrial cancers
8. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
9. Loss of heterozygosity of BRCA1, TP53 and TCRD markers analysed in sporadic endometrial cancer
10. PTEN mutation in endometrial cancers with 10q LOH additional evidence for the involvement of multiple tumor suppressors
11. Alteration of the p53 tumor suppressor gene and its association with activation of the c-k-ras-2 protoncogenein premalignant and malignant lesions of the human uterine endometrium
12. Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas
13. HER-2/neu expression: A major prognostic factor in endometrial carcinoma
14. Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma
15. Microsatellite instability in cervical and endometrial carcinomas
16. Microsatellite instability in endometrial carcinoma: Clinicopathologic correlations in a series of 42 cases
17. Causes and consequences of microsatellite instability in endometrial carcinoma
18. ++ endometrial cancers
19. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
20. MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers
21. Familial endometrial cancer in female carriers of MSH6 germline mutations
22. The DNA repair gene MB4 (MED1) is mutated in human carcinomas with microsatellite instability
23. Detection of gain and losses in primary endometrial carcinomas by comparative genomic hybridization
24. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers
25. Deletion mapping on chromosome 10q25-q26 in human endometrial cancer
26. Identification of a 790-kilobase region of common allelic loss in chromosome 10q25-q26 in human endometrial cancer
27. Mapping an endometrial cancer tumor suppressor gene at 10q25 and development of a bacterial clone contig for the consensus interval
28. Identification of a founder BRCA2 mutation in Sardinia
29. Tumor Registry of Sassari
30. Changes in gynecological cancer staging by the International Federation of Gynecology and Obstetrics
31. The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC)
32. Recent advances in the histopathology and molecular pathology of carcinoma of the endometrium
33. Strategies to screen colorectal cancer patients for hereditary non-polyposis colorectal cancer (HNPCC)
34. Mismatch repair, genetic stability, and cancer
35. Microsatellite instability: Marker of a mutator phenotype in cancer
36. Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
37. Better survival rates in patients with Mlh1-associated hereditary colon cancer
38. Genetic instabilities in human cancers
39. Microsatellite instability and somatic mutations in endometrial carcinomas
40. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients
41. Diagnostic microsatellite instability: Definition and correlation with mismatch repair protein expression
42. Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas
43. Mismatch repair gene defects contribute to the genetic basis of double primary cancers of the colorectum and endometrium
44. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
45. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
46. Mutations predisposing to hereditary nonpoliposis colorectal cancer