The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases

Biochemical Journal

Volumn 364, Issue 1, 2002, Pages 181-190

  Stanton, Heather ^a   Ung, Linh ^a   Fosang, Amanda J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CARTILAGE; DEGRADATION; ENZYMES; SYNTHESIS (CHEMICAL); TISSUE CULTURE;

RECEPTOR ANTAGONISTS;

COLLAGEN;

AGGRECAN; AGGRECANASE; COLLAGEN; COLLAGENASE 3; FIBRONECTIN; GELATINASE A; GENE PRODUCT; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PROTEIN FN F 45; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BINDING SITE; CARTILAGE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; ENZYME REGULATION; ENZYME RELEASE; ENZYME SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SYNOVIAL FLUID;

ANIMALIA; SUIDAE;

EID: 0037093523     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3640181     Document Type: Article

References (48)

1. Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments
2. Fragmented fibronectin and other synovial fluid proteins in chronic arthritis: Their relation to immune complexes
3. Fibronectin fragments in osteoarthritic synovial fluid
4. Intraarticular injection of fibronectin fragments causes severe depletion of cartilage proteoglycans in vivo
5. Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture
6. Proteoglycan-degrading activity associated with the 40 kDa collagen-binding fragment of fibronectin
7. The proteolytic activity and cleavage specificity of fibronectin-gelatinase and fibronectin-lamininase
8. Association of proteoglycan degradation with catabolic cytokine and stromelysin release from cartilage cultured with fibronectin fragments
9. Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1
10. Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines
11. Role of stromelysin-1 in cartilage metabolism
12. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage
13. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
14. Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)
15. Multiple modes of activation of latent human fibroblast collagenase: Evidence for the role of a cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation
16. Relating matrix metalloproteinase structure to function: Why the hemopexin domain?
17. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
18. Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins
19. Aggrecanase and cartilage proteoglycan degradation
20. ADAMTS: A novel family of extracellular matrix proteases
21. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)
22. Development of a cleavage site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: Detection of fragments in human synovial fluids
23. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase
24. 1 active forms of stromelysin to collagen is mediated by the C-terminal domain
25. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3
26. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants
27. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures
28. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates
29. Separation of fibronectin from a plasma gelatinase using immobilized metal affinity chromatography
30. 35S-labelled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography
31. Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid
32. r active forms, and a comparison of recombinant with natural stromelysin activities
33. Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
34. Fibronectin fragments induce the expression of stromelysin-1 mRNA and protein in bovine chondrocytes in monolayer culture
35. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change
36. Mechanisms for pro matrix metalloproteinase activation
37. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase A (MMP-2) are able to generate active enzyme
38. Cartilage chondrolysis by fibronectin fragments causes cleavage of aggrecan at the same site as found in osteoarthritic cartilage
39. Hyaluronan suppresses fibronectin fragment-mediated damage to human cartilage explant cultures by enhancing proteoglycan synthesis
40. Mechanisms involved in cartilage proteoglycan catabolism
41. Expression of ADAMTS homologues in articular cartilage
42. Expression and activity of ADAMTS-5 in synovium
43. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
44. Substrate-specific binding of the amino terminus of fibronectin to an integrin complex in focal adhesions
45. Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin
46. Release of biological activities from quiescent fibronectin by a conformational change and limited proteolysis by matrix metalloproteinases
47. Cartilage fibronectin isoforms: In search of functions for a special population of matrix glycoproteins