Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: Implications for Pelizaeus-Merzbacher disease

Journal of Cell Biology

Volumn 157, Issue 2, 2002, Pages 327-336

  Simons, Mikael ^a,b   Krämer, Eva Maria ^c,d   Macchi, Paolo ^b   Rathke Hartlieb, Silvia ^a   Trotter, Jacqueline ^d   Nave, Klaus Armin ^c   Schulz, Jörg B ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cholesterol; Myelin; Pelizaeus Merzbacher disease; Proteolipid protein; Rafts

Indexed keywords

CHOLESTEROL; DETERGENT; LIPID; PHOSPHATIDYLINOSITOL; PROTEIN; PROTEOLIPID PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CELL STRAIN BHK; CONTROLLED STUDY; ENDOSOME; GENE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; LYSOSOME; MOUSE; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PELIZAEUS MERZBACHER DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; CHOLIC ACIDS; CRICETINAE; ENDOSOMES; HOMEOSTASIS; LYSOSOMES; MEMBRANE MICRODOMAINS; MICE; MICE, TRANSGENIC; MYELIN PROTEOLIPID PROTEIN; OLIGODENDROGLIA; PELIZAEUS-MERZBACHER DISEASE; SOLUBILITY;

ANIMALIA; MUS MUSCULUS; SEMLIKI FOREST VIRUS;

EID: 0037092050     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200110138     Document Type: Article

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