Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells

Biochemical Pharmacology

Volumn 63, Issue 4, 2002, Pages 689-692

  Urbano, Alexander ^a   Gorgun, Gullu ^a   Foss, Francine ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

Akt; Apoptosis; BAD; Leukemia; Tyrphostins

Indexed keywords

AG 957; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; CARRIER PROTEINS; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR CELLS, CULTURED; TYRPHOSTINS;

EID: 0037085016     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00916-9     Document Type: Article

References (13)

1. Altered physical state of p210bcr-abl in tyrphostin AG957-treated K562 cells
2. Tyrphostin induced growth inhibition: Correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia
3. cbl phosphorylation in anti-CD3-stimulated T-lymphoblasts
4. The tryphostin AG17 induces apoptosis and inhibition of Cdk2 activity in a lymphoma cell line that overexpresses Bcl-2
5. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
6. Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts
7. + chronic myelogenous leukemia progenitor cells
8. Effects of the bcr-abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro
9. Transformation of hematopoietic cells by BCR-ABL requires activation of a PI-3k/Akt-dependent pathway
10. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
11. Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt
12. Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR-ABL mutant
13. Protein kinase Cι activity is necessary for bcr-abl-mediated resistance to drug-induced apoptosis