A human H19 transgene exhibits impaired paternal-specific imprint acquisition and maintenance in mice

Human Molecular Genetics

Volumn 11, Issue 4, 2002, Pages 411-418

  Jones, Beverly K ^a   Levorse, John ^a   Tilghman, Shirley M ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; DNA; RNA; SOMATOMEDIN B; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; AUTOSOME; BINDING SITE; CONTROLLED STUDY; DNA METHYLATION; EXTRACHROMOSOMAL INHERITANCE; GENE EXPRESSION; GENE SEQUENCE; GENETIC CODE; GENETIC CONSERVATION; GENETIC LINKAGE; GENOME IMPRINTING; GERM LINE; MALE; MAMMAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; TRANSGENE;

ANIMALIA; EUTHERIA; MAMMALIA;

EID: 0037084817     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.4.411     Document Type: Article

References (37)

1. The role of DNA methylation in genomic imprinting
2. De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch
3. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
4. Imprinted expression of the Igf2r gene depends on an intronic CpG island
5. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
6. Parental-origin-specific epigenetic modifications of the mouse H19 gene
7. A 5′ 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development
8. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
9. CTCF mediates methylation-sensitive enhancer blocking activity at the H19/Igf2 locus
10. Disruption of imprinting caused by deletion of the H19 gene region in mice
11. A transcriptional insulator at the imprinted H19/Igf2 locus
12. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
13. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
14. Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor
15. Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus
16. Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis
17. Epigenetic mark sequence of the H19 gene in human sperm
18. A potential imprint control element: Identification of a conserved 42 bp sequence upstream of H19
19. Imprinting of human H19: Allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching
20. Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor
21. Increased tumour risk for BWS patients correlates with aberrant H19 and not KCNQ1OT1 methylation: Occurrence of KCNQ1OT1 hypomethylation in familial cases of BWS
22. Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer
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24. A human p57(KIP2) transgene is not activated by passage through the maternal mouse germline
25. A model system to study genomic imprinting of human genes
26. A 5′ differentially methylated sequence and the 3′ flanking region are necessary for H19 transgene imprinting
27. The structural H19 gene is required for transgene imprinting
28. Imprinting of Igf2 and H19 from a 130 kb YAC transgene
29. Elucidation of the minimal sequence required to imprint H19 transgenes
30. Promoter-specific IGF2 imprinting status and its plasticity during human liver development
31. Demethylation of the zygotic paternal genome
32. Active demethylation of the paternal genome in the mouse zygote
33. Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo
34. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
35. Conservation of a maternal-specific methylation signal at the human IGF2R locus
36. Genomic imprinting is disrupted in interspecific Peromuscus hybrids
37. Genetic and epigenetic incompatibilties underlie hybrid dysgenesis in Peromyscus