Regression models for allele sharing: Analysis of accumulating data in affected sib pair studies

Statistics in Medicine

Volumn 21, Issue 3, 2002, Pages 431-444

  Bull, Shelley B ^a,b   Greenwood, Celia M T ^b   Mirea, Lucia ^b   Morgan, Kenneth ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Complex disease; EM algorithm; Family data; Genetic linkage; Hidden Markov model; Identical by descent

Indexed keywords

MICROSATELLITE DNA;

ALLELE; ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DATA ANALYSIS; DIAGNOSTIC VALUE; ENTERITIS; ETHNOLOGY; GENE MAPPING; GENETIC HETEROGENEITY; GENETIC MARKER; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; REGRESSION ANALYSIS; SEQUENCE ANALYSIS; SIBLING; STATISTICAL ANALYSIS;

ADOLESCENT; ALGORITHMS; ALLELES; CHROMOSOME MAPPING; DNA; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFLAMMATORY BOWEL DISEASES; JEWS; LINKAGE (GENETICS); LOD SCORE; MODELS, GENETIC; NUCLEAR FAMILY; ONTARIO; REGRESSION ANALYSIS;

EID: 0037083113     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1028     Document Type: Article

References (36)

1. Overview of mapping common and genetically complex human disease genes
2. Laboratory approaches toward gene identification
3. Construction of multilocus genetic linkage maps in humans
4. Genetic linkage analysis of complex genetic traits by using affected sibling pairs
5. A class of tests for linkage using affected pedigree members
6. Parametric and nonparametric linkage analysis: A unified multipoint approach
7. Allele-sharing models: LOD scores and accurate linkage tests
8. Optimal allele-sharing statistics for genetic mapping using affected relatives
9. A general conditional-logistic model for affected-relative-pair linkage studies
10. Multilocus linkage tests based on affected relative pairs
11. Analysis of affected sib pairs, with covariates - With and without constraints
12. Genome scanning for linkage: An overview
13. Tutorial in biostatistics: Genetic mapping of complex traits
14. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
15. Multipoint linkage analysis using affected relative pairs and partially informative markers
16. Two-stage global search designs for linkage analysis using pairs of affected relatives
17. Genetic dissection of complex traits
18. Sequential test for the detection of linkage
19. Rejoinder
20. Stratified linkage analysis of complex genetic traits using related covariates
21. Interim linkage analysis in mapping complex traits. Annual Meeting of the American Society for Human Genetics
22. The use of sequential designs in genome scans for asthma susceptibility loci with affected sib pairs
23. A single, sequential, genome-wide test to identify simultaneously all promising areas in a linkage scan
24. Statistical approaches to interim monitoring of medical trials: A review and commentary
25. Complete multipoint sib-pair analysis of qualitative and quantitative traits
26. Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder
27. Asymptotic properties of affected-sib-pair linkage analysis
28. Diabetes, dependence, asymptotics, selection and significance
29. Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data
30. Down-weighting of multiple affected sib pairs leads to biased likelihood-ratio tests, under the assumption of no linkage
31. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
32. Preliminary report on the Mount Sinai Hospital Inflammatory Bowel Disease Genetics Project
33. The future of genetic studies of complex human diseases
34. Population choice in mapping genes for complex diseases
35. Searching for genetic determinants in the new millennium