A bacterial model system for understanding multi-drug resistance

Microbial Drug Resistance

Volumn 3, Issue 4, 1997, Pages 289-295

  Saier Jr , Milton H ^a   Paulsen, Ian T ^a,b   Matin, A ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CHLORAMPHENICOL; DAUNORUBICIN; ETHIDIUM; NALIDIXIC ACID; PARAQUAT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RHODAMINE 6G; TETRACYCLINE; TETRAPHENYLPHOSPHONIUM; THIOLACTOMYCIN;

ARTICLE; BACTERIAL GENE; BACTERIUM; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS);

EID: 0031405597     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.1997.3.289     Document Type: Article

References (17)

1. Ahmed, M., C.M. Borsch, A.A. Neyfakh, and S. Schuldiner. 1993. Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine. J. Biol. Chem. 268:11086-11089.
2. Arkin, I.T., W.P. Russ, M. Lebendiker, and S. Schuldiner. 1996. Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four-helix bundle. Biochemistry 35:7233-7238.
3. Arthur, M., P. Reynolds, and P. Courvalin. 1996. Glycopeptide resistance in enterococci. Trends Microbiol. 4:401-407.
4. Bellamy, W.T. 1996. P-glycoproteins and multidrug resistance. Annu. Rev. Pharmacol. Toxicol. 36:161-183.
5. Blanc, V., K. Salah-Bey, M. Folcher, and C.J. Thompson. 1995. Molecular characterization and transcriptional analysis of a multidrug resistance gene cloned from the pristinamycin-producing organism, Streptomyces pristinaespiralis. Mol. Microbiol. 17:989-999.
6. Dinh, T., I.T. Paulsen, and M.H. Saier, Jr. 1994. A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. J. Bacteriol. 176:3825-3831.
7. Dunten, R.L., M. Sahin-Toth, and H.R. Kaback. 1993. Cysteine scanning mutagenesis of putative helix XI in the lactose permease of Escherichi coli. Biochemistry 32:12644-12650.
8. George, A.M. 1996. Multidrug resistance in enteric and other gram-negative bacteria. FEMS Microbiol. Lett. 139:1-10.
9. Goswitz, V.C., and R.J. Brooker. 1993. Isolation of lactose permease mutants which recognize arabinose. Membr. Biochem. 10:61-70.
10. Gottesman, M.M., and I. Pastan. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427.
11. Gottesman, M.M., C.A. Hrycyna, P.V. Schoenlein, U.A. Ger-mann, and I. Pastan. 1995. Genetic analysis of the multidrug transporter. Annu. Rev. Genet. 29:607-649.
12. Greener, T., D. Govenzenshy, and A. Zamir. 1993. A novel multicopy suppressor of a groEL mutation includes two nested open reading frames transcribed from different promoters. EMBO J. 12:889-896.
13. Griffith, J.K., M.E. Baker, D.A. Rouch, M.G.P. Page, R.A. Skurray, I.T. Paulsen, K.F. Chater, S.A. Baldwin, and P.J.F. Henderson. 1992. Membrane transport proteins: Implications of sequence comparisons. Curr. Opin. Cell. Biol. 4:684-695.
14. Grinius, L.L., and E.B. Goldberg. 1994. Bacterial multidrug resistance is due to a single membrane protein which functions as a drug pump. J. Biol. Chem. 269:29998-30004.
15. Gros, P., and M. Hanna. 1996. The P-glycoprotein family and multidrug resistance: An overview, pp. 137-163. In W.N. Konings, H.R. Kaback, and J.S. Lolkema (eds.), Handbook of biological physics, Vol. 2, North Holland, Amsterdam.
16. Hagman, K.E., W. Pan, B.G. Spratt, J.T. Balthazar, R.C. Judd, and W.M. Shafer. 1995. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 141:611-622.
17. Higgins, D.F. 1992. ABC transporters: From microorganisms to man. Annu. Rev. Cell Biol. 8:67-113.