PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac

Blood

Volumn 99, Issue 2, 2002, Pages 694-697

  Kim, Jong Suk ^a,b   Peng, Xiaodong ^a,b   De, Pradip K ^a,b   Geahlen, Robert L ^a,b   Durden, Donald L ^a,b,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; GUANOSINE TRIPHOSPHATE; IMMUNOGLOBULIN G; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RAC PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SPECIFICITY; ERYTHROCYTE; INFLAMMATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SEQUENCE HOMOLOGY; SHEEP; SIGNAL TRANSDUCTION;

EID: 0037079729     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.2.694     Document Type: Article

References (28)

1. The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains
2. The FcγRI receptor signals through the activation of hck and MAP kinase
3. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn
4. Protein-tyrosine kinase p72syk in FcγRI receptor signaling
5. Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase
6. CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling
7. Ras-related GTP-binding proteins and leukocyte signal transduction
8. Induction of phagocytosis by a protein tyrosine kinase
9. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages
10. Clustered syk tyrosine kinase domains trigger phagocytosis
11. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
12. Visualization of Syk-antigen receptor interactions using green fluorescent protein: Differential roles for Syk and Lyn in the regulation of receptor capping and internalization
13. A role for Shc, Grb2, and Raf-1 in FcgammaRI signal relay
14. The molecular dissection of Fc gamma receptor mediated phagocytosis
15. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
16. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
17. PTEN controls tumor-induced angiogenesis
18. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
19. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
20. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
21. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
22. Impaired Fas response and autoimmunity in Pten+/-mice
23. Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5
24. Influence of tyrosine phosphorylation on protein interaction with Fc-gammaRila
25. Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif: Reconstitution with synthetic phosphopeptides
26. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase
27. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
28. A regulatory role for Src homology 2 domain-containing inositol 5′-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha (M)beta(2); CD11b/CD18)