Guaianolides from Viguiera gardneri inhibit the transcription factor NF-κB

Phytochemistry

Volumn 60, Issue 7, 2002, Pages 733-740

  Schorr, Karin ^a   García Piñeres, Alfonso J ^b   Siedle, Bettina ^b   Merfort, Irmgard ^b   Da Costa, Fernando B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anti inflammatory activity; Asteraceae; Heliantheae; Low energy conformation; NF B; Sesquiterpene lactones; Viguiera gardneri

Indexed keywords

2ALPHA,3BETA DIHYDROXY 8BETA METHACRYLOYLOXYGERMACRA 1(10),4,11,(13) TRIEN 6ALPHA,12 OLIDE; 8BETA METHACRYLOYLOXY 10ALPHA HYDROXYGUAIA 3,11(13) DIEN 6ALPHA,12 OLID 2 ONE; 8BETA METHACRYLOYLOXY 10BETA HYDROXYGUAIA 3,11(13) DIEN 6ALPHA,12 OLID 2 ONE; 8BETA METHACRYLOYLOXYGUAIA 1(10),3,11(13) TRIEN 6ALPHA,12 OLID 2 ONE; 8BETA TIGOLYLOXYGUAIA 1(10),3,11(13) TRIEN 6ALPHA,12 OLID 2 ONE; ANTIINFLAMMATORY AGENT; GUAIANOLIDE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SESQUITERPENE; SESQUITERPENE LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTERACEAE; BINDING KINETICS; CALCULATION; CHEMICAL STRUCTURE; CHEMISTRY; CONTROLLED STUDY; DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHORETIC MOBILITY; GEL MOBILITY SHIFT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOLATION AND PURIFICATION; LEUKEMIA CELL LINE; PLANT LEAF; QUANTUM MECHANICS; REGULATORY MECHANISM; SPECTROSCOPY; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; TRICHOME; VIGUIERA GARDNERI; DRUG ANTAGONISM;

ASTERACEAE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMAN; JURKAT CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NF-KAPPA B; SESQUITERPENES; SPECTRUM ANALYSIS; SUPPORT, NON-U.S. GOV'T; HUMANS;

ASTERACEAE; HELIANTHEAE; VIGUIERA; VIGUIERA GARDNERI;

EID: 0037077415     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9422(02)00197-8     Document Type: Article

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