Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: Implications for mode of binding of ligands with uncharged chromophores

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 894-901

  Wakelin, Laurence P G ^a   Adams, Adrienne ^b   Denny, William A ^c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE DERIVATIVE; AMIDE; AMMONIUM DERIVATIVE; CYTOTOXIC AGENT; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DODECYL SULFATE SODIUM; GUANINE; N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE; N [(2 DIMETHYLAMINO)ETHYL] 9 AMINOACRIDINE 4 CARBOXAMIDE; PHENAZINE 4 CARBOXAMIDE DERIVATIVE; PHENAZINECARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CHROMATOPHORE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DISSOCIATION; DNA DRUG COMPLEX; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HYDROGEN BOND; INTERCALATION COMPLEX; LEUKEMIA CELL; MOUSE; NONHUMAN; SPECTROPHOTOMETRY;

ACRIDINES; AMIDES; ANTINEOPLASTIC AGENTS; DNA; DNA TOPOISOMERASES; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; INTERCALATING AGENTS; KINETICS; LIGANDS; MODELS, MOLECULAR; PHENAZINES;

EID: 0037075118     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000473g     Document Type: Article

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