Distinct mechanisms of Taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1590, Issue 1-3, 2002, Pages 76-83

  Yang, Chia Ping Huang ^a   Horwitz, Susan Band ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Macrophage; Microtubule interacting agent; p66shc phosphorylation; Taxol

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLCHICINE; DISCODERMOLIDE; DOCETAXEL; EPOTHILONE A; EPOTHILONE B; ISOPROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; PACLITAXEL; PROTEIN SHC; RAF PROTEIN; RAF1 PROTEIN; SERINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MACROPHAGE; MICROTUBULE; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BUTADIENES; CELL LINE; ENZYME INHIBITORS; GENE EXPRESSION; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; PHOSPHORYLATION; PROTEINS; PYRIDINES; SERINE; THREONINE; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 0037067132     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(02)00200-8     Document Type: Article

References (36)

1. Paclitaxel (taxol)
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4. Taxol stabilizes microtubules in mouse fibroblast cells
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6. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells
7. Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
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11. Taxol and lipopolysaccharide activation of a murine macrophage cell line and induction of similar tyrosine phosphoproteins
12. Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase
13. Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line
14. Taxol provides a second signal for murine macrophage tumoricidal activity
15. Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity
16. Shared actions of endotoxin and Taxol on TNF receptors and TNF release
17. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide
18. Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: Identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression
19. Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein
20. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
21. Not all Shc's roads lead to Ras
22. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
23. The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway
24. Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways
25. The p66shc adaptor protein controls oxidative stress response and life span in mammals
26. Endothelin-1 induces serine phosphorylation of the adaptor protein p66shc and its association with 14-3-3 protein in glomerular mesangial cells
27. Elevated levels of p66 Shc are found in breast cancer cell lines and primary tumors with high metastatic potential
28. Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells
29. Taxol mediates serine phosphorylation of the 66-kDa Shc isoform
30. Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis
31. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines
32. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
33. C-Jun N-terminal kinase specifically phosphorylates p66shcA at serine 36 in response to ultraviolet irradiation
34. Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity
35. Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages
36. Structural significance of the acyl group at the C-10 position and the A ring of the taxane core of paclitaxel for inducing niric oxide and tumor necrosis factor production by murine macrophages