Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)

Genes Chromosomes and Cancer

Volumn 31, Issue 4, 2001, Pages 382-389

  Dahéron, Laurence ^a   Veinstein, Anne ^a,b   Brizard, Françoise ^a,b   Drabkin, Harry ^c   Lacotte, Laurence ^a   Guilhot, François ^a   Larsen, Christian Jacques ^b   Brizard, André ^a,b   Roche, Joelle ^b  

^a POITIERS UNIVERSITY HOSPITAL   (France)

^b IBMIG Institut de Biologie Moleculaire et dIngenierie Genetique   (France)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GYRASE INHIBITOR; HYBRID PROTEIN; LEUCINE ZIPPER PROTEIN; METHYLTRANSFERASE; MIXED LINEAGE LEUKEMIA PROTEIN; PROLINE; PROTEIN LPP; UNCLASSIFIED DRUG; ZYXIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ADULT; ARTICLE; CASE REPORT; CHROMOSOME 3Q; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 3; CLINICAL FEATURE; DISEASE COURSE; EXON; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR LYMPHOMA; GENE DELETION; GENE FUSION; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; INTRON; LIPOMA; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TREATMENT OUTCOME;

ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 3; CLONING, MOLECULAR; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; FATAL OUTCOME; FEMALE; HUMANS; KARYOTYPING; LEUKEMIA, MONOCYTIC, ACUTE; LYMPHOMA, FOLLICULAR; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASMS, SECOND PRIMARY; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENES; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0034936456     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1157     Document Type: Article

References (27)

1. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British cooperative group
2. Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations
3. An MLL-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
4. Tumorigenesis in mice with a fusion of the leukaemia oncogene MLL and the bacterial lacZ gene
5. Secondary leukemias induced by topoisomerase-targeted drugs
6. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
7. Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia
8. Leukemias induced by anticancer chemotherapies
9. Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation
10. Comprehensive and definitive molecular cytogenetic characterization of Hela cells by spectral karyotyping
11. Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias
12. Genes on chromosome 4, 9 and 19 involved in 11q23 abnormalities in acute leukemia share homology and/or common motifs
13. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family
14. Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma
15. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity
16. The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype
17. 11q23 rearrangements in acute leukemia
18. Novel SH3 protein encoded by AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23)
19. ALL-1 partial duplication in acute leukemia
20. The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator
21. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites
22. An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region
23. Classification of LIM domains
24. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
25. A procedure for in vitro amplification of DNA segments that lie outside the boundaries of known sequences
26. Altered Hox expression and segmental identity in Mll-mutant mice