The CDCRELI gene fused to MLL in de novo acute myeloid leukemia with t(11;22)(q23;q11.2) and its frequent expression in myeloid leukemia cell lines

Genes Chromosomes and Cancer

Volumn 30, Issue 3, 2001, Pages 230-235

  Tatsumi, Ken ^a   Taki, Tomohiko ^b   Taniwaki, Masafumi ^c   Nakamura, Hideo ^a   Taguchi, Jun ^c   Chen, Ying Zhang ^b   Bessho, Fumio ^b   Yanagisawa, Masayoshi ^a   Hayashi, Yasuhide ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GLYCOPROTEIN IB; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN CDCRELI; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; MESSENGER RNA; MLL PROTEIN, HUMAN; ONCOPROTEIN; SEPT5 PROTEIN, HUMAN; THROMBIN RECEPTOR; TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHROMOSOME TRANSLOCATION 11; EXON; GENE EXPRESSION; GENE FUSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKEMOGENESIS; MALE; PRIORITY JOURNAL; PROTEIN DOMAIN; ADULT; AMINO ACID SEQUENCE; BIOSYNTHESIS; CASE REPORT; CELL CULTURE; CHROMOSOME 11; CHROMOSOME 22; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTO ONCOGENE;

EB VIRUS;

ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL CYCLE PROTEINS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 22; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTO-ONCOGENES; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0034746545     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2264(2000)9999:9999<::AID-GCC1084>3.0.CO;2-J     Document Type: Article

References (27)

1. Localization of a novel septin protein, hCDCrel-1, in neurons of human brain
2. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
3. Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34+ cells
4. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
5. Immunoglobulin heavy chain gene rearrangements and mixed lineage characteristics in acute leukemias with the 11;19 translocation
6. HRX involvement in de novo and secondary leukemias with diverse chromosome 11qZ3 abnormalities
7. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23; q13)
8. MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13
9. Clinical and hematologic characteristics in acute leukemia with 11q23 translocations
10. t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MlLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes
11. MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)
12. Biology and treatment of infant leukemias
13. The critical role of chromosome translocations in human leukemias
14. 11q23 rearrangements in acute leukemia
15. Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia
16. The t(11;16)(q23; p13) translocation in myelodysplastic syndrome fulses the MLL gene to the CBP gene
17. AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25)
18. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with inv(5;11)
19. Interphase and metaphase detection of the breakpoint of 14q32 translocations in B-cell malignancies by double-color fluorescence in situ hybridization
20. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations
21. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocation in acute leukemias
22. Deletions within chromosome 22q11 in familial congenital heart disease
23. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children
24. Structure and expression of the human septin gene HCDCREL-1
25. Altered Hox expression and segmental identity in Mll-mutant mice
26. Alternative expression of platelet glycoprotein 1b mRNA from an adjacent 5′ gene with an imperfect polyadenylation signal sequence
27. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias