Construction and immunogenicity of a codon-optimized Entamoeba histolytica Gal-lectin-based DNA vaccine

Vaccine

Volumn 20, Issue 27-28, 2002, Pages 3244-3253

  Gaucher, Denis ^a   Chadee, Kris ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Amebiasis; Codon bias optimization; Mammalian gene expression

Indexed keywords

DNA VACCINE; GALACTOSE ADHERENCE LECTIN; LECTIN; UNCLASSIFIED DRUG;

AMEBIASIS; ARTICLE; CELL DESTRUCTION; CELLULAR IMMUNITY; CODON; CONTROLLED STUDY; DNA SEQUENCE; ENTAMOEBA HISTOLYTICA; IMMUNOGENICITY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TARGET CELL; TROPHOZOITE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; BASE SEQUENCE; CODON; COS CELLS; DNA, PROTOZOAN; ENTAMOEBA HISTOLYTICA; ENTAMOEBIASIS; FEMALE; GALECTINS; HUMANS; IMMUNITY, CELLULAR; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEIN SUBUNITS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; TH1 CELLS; VACCINES, DNA;

EID: 0037055967     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00303-1     Document Type: Article

References (45)

1. WHO. WHO/PAHO/UNESCO report of a consultation of experts on amoebiasis. Week Epidem Rec WHO 1997;72:97-9.
2. Haque R., Ali I.K.M., Sack R.B., Farr B.M., Ramakrishnan G., Petri W.A. Jr. Amebiasis and mucosal IgA antibody against the Entamoeba histolytica adherence lectin in Bangladeshi children. J. Infect. Dis. 183:2001;1787-1793.
3. Campbell D., Chadee K. Interleukin (IL)-2, IL-4, and tumor necrosis factor-alpha responses during Entamoeba histolytica liver abscess development in gerbils. J. Infect. Dis. 175:1997;1176-1183.
4. Salata R.A., Martinez-Palomo A., Murray H.W.et al. Patients treated for amebic liver abscess develop cell-mediated immune responses effective in vitro against Entamoeba histolytica. J. Immunol. 136:1986;2633-2639.
5. Salata R.A., Murray H.W., Rubin B.Y., Ravdin J.I. The role of gamma interferon in the generation of human macrophages cytotoxic for Entamoeba histolytica trophozoites. Am. J. Trop. Med. Hyg. 37:1987;72-78.
6. Salata R.A., Pearson R.D., Ravdin J.I. Interaction of human leukocytes and Entamoeba histolytica. Killing of virulent amebae by the activated macrophage. J. Clin. Invest. 76:1985;491-499.
7. Petri W.A. Jr., Smith R.D., Schlesinger P.H., Murphy C.F., Ravdin J.I. Isolation of the galactose-binding lectin that mediates the in vitro adherence of Entamoeba histolytica. J. Clin. Invest. 80:1987;1238-1244.
8. Petri W.A. Jr., Broman J., Healy G., Quinn T., Ravdin J.I. Antigenic stability and immunodominance of the Gal/GalNAc adherence lectin of Entamoeba histolytica. Am. J. Med. Sci. 296:1989;163-165.
9. Petri W.A. Jr., Ravdin J.I. Protection of gerbils from amebic liver abscess by immunization with the galactose-specific adherence lectin. Infect. Immun. 59:1991;97-101.
10. Zhang T., Stanley S.L. Jr. Protection of gerbils from amebic liver abscess by immunization with a recombinant protein derived from the 170-kilodalton surface adhesin of Entamoeba histolytica. Infect. Immun. 62:1994;2605-2608.
11. Soong C.-J.G., Kain K.C., Abd-Alla M., Jackson T.F.H.G., Ravdin J.I. A recombinant cysteine-rich section of the Entamoeba histolytica galactose inhibitable lectin is efficacious as a subunit vaccine in the gerbil model of amebic liver abscess. J. Infect. Dis. 171:1995;645-651.
12. Mann B.J., Burkholder B.V., Lockhart L.A. Protection in a gerbil model of amebiasis by oral immunization with Salmonella expressing the galactose N-acetyl D-galactosamine inhibitable lectin of Entamoeba histolytica. Vaccine. 15:1997;659-663.
13. Lotter H., Zhang T., Seydel K.B., Stanley S.L. Jr., Tannich E. Identification of an epitope on the Entamoeba histolytica 170-kD lectin conferring antibody-mediated protection against invasive amebiasis. J. Exp. Med. 185:1997;1793-1801.
14. Petri W.A. Jr., Snodgrass T.L., Jackson T.F.H.G. Monoclonal antibodies directed against the galactose-binding lectin of Entamoeba histolytica enhance adherence. J. Immunol. 144:1990;4803-4809.
15. Séguin R., Mann B.J., Keller K., Chadee K. Identification of the galactose-adherence lectin epitopes of Entamoeba histolytica that stimulate tumor necrosis factor-α production by macrophages. Proc. Natl. Acad. Sci. U.S.A. 92:1995;12175-12179.
16. Kelsall B.L., Ravdin J.I. Immunization of rats with the 260-kilodalton Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence-inhibitory activity. Infect. Immun. 63:1995;686-689.
17. Halpern M.D., Kurlander R.J., Pisetsky D.S. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell Immunol. 167:1996;72-78.
18. Chadee K., Meerovitch E. The Mongolian gerbil (Meriones unguiculatus) as an experimental host for Entamoeba histolytica. Am. J. Trop. Med. Hyg. 33:1984;47-54.
19. Ausubel FM, Brent R, Kingston RE, et al. Current Protocols in Molecular Biology. New York: Wiley, 1999.
20. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
21. Mann B.J., Chung C.Y., Dodson J.M., Ashley L.S., Braga L.L., Snodgrass T.L. Neutralizing monoclonal antibody epitopes of the Entamoeba histolytica galactose adhesin map to the cysteine-rich extracellular domain of the 170-kilodalton subunit. Infect. Immun. 61:1993;1772-1778.
22. Mishell BB, Shiigi SM. Selected Methods in Cellular Immunology. San Francisco: Freeman, 1980.
23. Belley A., Keller K., Grove J., Chadee K. Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. Gastroenterology. 111:1996;1484-1492.
24. Diamond L.S., Harlow D.R., Cunnick C. A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba. Trans. R. Soc. Trop. Med. Hyg. 72:1978;431-432.
25. Ravdin J.I., Murphy C.F., Salata R.A., Guerrant R.L., Hewlett E.L. N-Acetyl-D-Galactosamine-inhibitable adherence lectin of Entamoeba histolytica. Part I. Partial purification and relation to amoebic virulence in vitro. J. Infect. Dis. 151:1985;804-815.
26. Zolotukhin S., Potter M., Hauswirth W.W., Guy J., Muzyczka N. A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J. Virol. 70:1996;4646-4654.
27. Kim C.H., Oh Y., Lee T.H. Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells. Gene. 199:1997;293-301.
28. Andre S., Seed B., Eberle J., Schraut W., Bültmann A., Haas J. Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage. J. Virol. 72:1998;1497-1503.
29. Nagata T., Uchijima M., Yoshida A., Kawashima M., Koide Y. Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganisms. Biochem. Biophys. Res. Commun. 261:1999;445-451.
30. Char S., Farthing M.J.G. Codon usage in Entamoeba histolytica. Int. J. Parasitol. 22:1992;381-383.
31. Petitclerc D., Attal J., Theron M.C.et al. The effect of various introns and transcription terminators on the efficiency of expression vectors in various cultured cell lines and in the mammary gland of transgenic mice. J. Biotechnol. 40:1995;169-178.
32. Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:1987;8125-8148.
33. McCaughan K.K., Brown C.M., Dalphin M.E., Berry M.J., Tate W.P. Translational termination efficiency in mammals is influenced by the base following the stop codon. Proc. Natl. Acad. Sci. U.S.A. 92:1995;5431-5435.
34. Ravdin J.I., Jackson T.F.H.G., Petri W.A. Jr.et al. Association of serum anti-adherence lectin antibodies with invasive amebiasis and asymptomatic pathogenic Entamoeba histolytica. J. Infect. Dis. 162:1990;768-772.
35. Petri W.A. Jr., Jackson T.F.H.G., Gathiram V.et al. Pathogenic and nonpathogenic strains of Entamoeba histolytica can be differentiated by monoclonal antibodies to the galactose-specific adherence lectin. Infect. Immun. 58:1990;1902-1906.
36. Pillai D.R., Wan P.S.K., Yau Y.C.W., Ravdin J.I., Kain K.C. The cysteine-rich region of the Entamoeba histolytica adherence lectin (170-kilodalton subunit) is sufficient for high-affinity Gal/GalNAc-specific binding in vitro. Infect. Immun. 67:1999;3836-3841.
37. Dodson J.M., Lenkowski P.W. Jr., Eubanks A.C.et al. Infection and immunity mediated by the carbohydrate recognition domain of the Entamoeba histolytica Gal/GalNAc lectin. J. Infect. Dis. 179:1999;460-466.
38. Lotter H., Khajawa F., Stanley S.L. Jr., Tannich E. Protection of gerbils from amebic liver abscess by vaccination with a 25-mer peptide derived from the cysteine-rich region of Entamoeba histolytica galactose-specific adherence lectin. Infect. Immun. 68:2000;4416-4421.
39. Zhang T., Cieslak P.R., Foster L., Kuntz-Jenkins C., Stanley S.L. Jr. Antibodies to the serine rich Entamoeba histolytica protein (SREHP) prevent amoebic liver abscess in severe combined immunodeficient (SCID) mice. Parasite Immunol. 16:1994;225-230.
40. Calderon J., Munoz M., Acosta H.M. Surface redistribution and release of antibody-induced caps in Entamoebae. J. Exp. Med. 151:1980;184-193.
41. Tran V.Q., Herdman D.S., Torian B.E., Reed S.L. The neutral cysteine proteinase of Entamoeba histolytica degrades IgG and prevents its binding. J. Infect. Dis. 177:1998;508-511.
42. Schain D.C., Salata R.A., Ravdin J.I. Development of amebicidal cell-mediated immunity in gerbils (Meriones unguiculatus) immunized with the galactose-inhibitable lectin of Entamoeba histolytica. J. Parasitol. 81:1995;563-568.
43. Campbell D., Mann B.J., Chadee K. A subunit vaccine candidate region of the Entamoeba histolytica galactose-adherence lectin promotes interleukin-12 gene transcription and protein production in human macrophages. Eur. J. Immunol. 30:2000;423-430.
44. Beving D.E., Soong C.-J.G., Ravdin J.I. Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity. Infect. Immun. 64:1996;1473-1476.
45. Barnes A.G., Barnfield C., Brew R., Klavinskis L.S. Recent developments in mucosal delivery of pDNA vaccines. Curr. Opin. Mol. Ther. 2:2000;87-93.