Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)

Environmental Toxicology and Chemistry

Volumn 20, Issue 6, 2001, Pages 1216-1227

  Lange R ^a   Hutchinson, T H ^a   Croudace, C P ^a   Siegmund, F ^a   Schweinfurth, H ^a   Hampe, P ^a   Panter, G H ^a   Sumpter, J P ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Endocrine disruptor; Estrogen; Ethinylestradiol; Fish; Life cycle

Indexed keywords

DATA ACQUISITION; HISTOLOGY; THERMAL EFFECTS; TISSUE;

RADIOIMMUNOASSAYS;

MARINE BIOLOGY;

ETHINYLESTRADIOL;

CHEMICAL POLLUTANT; FISH; LIFE CYCLE; POLLUTION EXPOSURE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ECOTOXICITY; EMBRYO; ENVIRONMENTAL EXPOSURE; FEMALE; FERTILIZATION; FISH; GROWTH; HATCHING; LARVA; LIFE CYCLE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RADIOCHEMISTRY; REPRODUCTIVE TOXICITY; SEX DIFFERENTIATION; SEX RATIO; SEXUAL DEVELOPMENT; SURVIVAL; TEMPERATURE DEPENDENCE;

ANIMALS; BIOLOGICAL MARKERS; CYPRINIDAE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, NONMAMMALIAN; ESTRADIOL CONGENERS; ETHINYL ESTRADIOL; FEMALE; FERTILITY; LARVA; LIFE CYCLE STAGES; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OVARY; RADIOIMMUNOASSAY; SEX RATIO; SURVIVAL ANALYSIS; TESTIS; VITELLOGENINS;

EID: 0034830871     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1002/etc.5620200610     Document Type: Article

References (40)

1. Estrogenic effects of effluent from sewage treatment works
2. Widespread sexual disruption in wild fish
3. Feminized responses in fish to environmental estrogens
4. Vitellogenin induction and reduced serum testosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant
5. Xenobiotic modulation of endocrine function in fishes
6. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals
7. Oestrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen
8. A survey of estrogenic activity in United Kingdom inland waters
9. Estrogenic activity in five United Kingdom rivers detected by measurement of vitellogenesis in caged male trout
10. Identification of estrogenic chemicals in sewage treatment works effluent. 1. Chemical fractionation and in vitro biological screening
11. Identification of estrogenic chemicals in sewage treatment works effluent. 2. In vivo responses in trout and roach
12. Ethinyloestradiol - An undesired fish contraceptive?
13. Behaviour and occurrence of estrogen in municipal sewage treatment plants - Investigations in Germany, Canada and Brazil
14. Determination of natural and synthetic estrogens in sewage plants and river water
15. Endocrine modulating substances in the environment - Estrogenic effects of pharmaceutical products
16. Clinical pharmacokinetics of oral contraceptive steroids
17. Estrogen as an environmental pollutant
18. Reproductive physiology
19. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment
20. The comparative effectiveness of the natural and synthetic estrogen for the direct feminisation of chinook salmon
21. Evaluation of tests with early life-stages of fish for predicting long term toxicity
22. Measurement of vitellogenin, a biomarker for exposure to estrogenic chemicals, in a wide variety of cyprinid fish
23. Isolation and characterisation of the receptor for vitellogenin from the follicles of the rainbow trout (Oncorhynchus mykiss)
24. A multiple comparison rank sum test: Treatments versus control
25. The relevance of the presence of certain synthetic steroids in the aquatic environment
26. Effect of temperature and size on development, mortality and survival rates of the pelagic early life history stages of marine fish
27. Chemically induced alterations in functional development and reproduction of fishes
28. Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife
29. An in vivo testing system for endocrine disruptors in fish early life-stages using induction of vitellogenin
30. Adverse reproductive effects in male fathead minnows (Pimephales promelas) exposed to environmentally relevant concentrations of the natural estrogens, oestradiol and oestrone
31. Transformation of a non-estrogenic steroid metabolite to an estrogenically active substance by minimal bacterial activity
32. Pathological effects of orally administered estradiol to rainbow trout
33. Wildlife and endocrine disruptors: Requirements for hazard identification
34. Initial predictions of the concentrations and distribution of 17β-oestradiol, oestrone and ethinylestradiol in three English rivers