The toxic effect of the antibiotic metronidazole on aquatic organisms

Chemosphere

Volumn 35, Issue 11, 1997, Pages 2553-2561

  Lanzky, P F ^a   Halling Sorensen B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Acartia tonsa; Algal species; Brachydanio rerio; Ecotoxicity; Medicinal substances; Metronidazole

Indexed keywords

ANTIBIOTIC AGENT; DRUG METABOLITE; METRONIDAZOLE;

ALGA; ARTICLE; CHLORELLA; ECOTOXICOLOGY; ENVIRONMENTAL MONITORING; TIME; TOXICITY TESTING; WATER POLLUTION;

ANIMALS; ANTITRICHOMONAL AGENTS; CHLORELLA; CRUSTACEA; FRESH WATER; LETHAL DOSE 50; METRONIDAZOLE; WATER POLLUTANTS; ZEBRAFISH;

ACARTIA TONSA; ALGAE; CHLORELLA SP.; DANIO RERIO; SELENASTRUM CAPRICORNUTUM;

EID: 0030732263     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(97)00324-X     Document Type: Article

References (34)

1. Andersen, H (1994): Statistiske metoder til vurderng af spildevands toksisitet M. Sc. Thesis 7/94. Institute of Mathematical Modelling, The Technical University of Denmark, Lyngby, Denmark (in danish).
2. Andersen, M., Binderup, M. L., Kiel, P., and Larsen, H. (1982): Mutagenicity of metronidazole. Arch. Pharm. Chemi. Sci. Ed.; 10(1), 25-44.
3. British Pharmacopoeia (1993). Vol. I. HMSO. London. UK
4. Budavari, S. (Ed.) (1996): The Merck Index. An Encyclopedia of Chemicals, Drugs, and Biologicals. 12th Edition. Merck Research Laboratories. Merck & Co., Inc. Whitehouse Station, N. J. USA.
5. Cantelli Forti, G., Guerra, M C., Hrelia, P., Barbaro, A. M., and Biagi, G. L. (1984): Urinary excretion of mutagenic forms of metronidazole and nine related compounds as detected by HPLC. Drugs under experimental and clinical research; 10(5), 325-331.
6. ClogP for Windows. Version 1.0.0 1995 BioByte Corp. Claremont, Ca, USA.
7. Connor, T. H., Stoeckel, M, Fyrard, J., and Legator, M. S. (1977): Contribution of metronidazole and two metabolites to the mutagenic activity detected in urine of treated humans and mice. Cancer Research; 37 (Feb), 629-633.
8. Dobiás, L., Cerná, M., Rössner, P., and Srám, R. (1994): Genotoxicity and carcinogenicity of metronidazole. Mutation Research 317.177-194.
9. DS/ISO 7346-1 (1984): Water quality - Determination of the acute lethal toxicity of substances to a freshwater fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] - Part 1 : Static method.
10. Eckel, W. P., Ross, B., and Isensee, R. K. (1993): Pentobarbital Found in Ground Water. Ground Water Vol. 31, No. 5, 801-804.
11. Harries, J. E., Sheahan, D. A., Rycroft, R., Matthiessen, P., Sumpter, J. P., Jobling, S., and Routledge E. J. (1994): Evidence of oestrogenic activity in U.K. inland waters. Proceedings, Estrogens in the Environment III: Global Health Implications. Washington, DC, January 9-11, xx-xx.
12. Hektoen, H., Berge, J. A., Hormazabal, V., and Yndestad, M. (1995): Persistence of antibacterial agents in marine sediments. Aquaculture 133. 175-184.
13. Holm. J. V., Rügge, K., Bjerg, P. L., and Christensen T. H. (1995): Occurence and Distribution of Pharmaceutical Organic Compounds in the Groundwater Downgradient of a Landfill (Grindsted. Denmark). Environmental Science & Technology Vol. 29, No 5. 1415-1420.
14. ISO 8692 (1989): Water quality - Fresh water algal growth inhibition test with Scenedesmus subspicatus and Selenastrum capricomutum. International Organization for Standardization, Geneva, Switzerland.
15. Jørgensen, S. E. and Johnson, I. (1989): Principles of Environmental Science and Technology, p. 128 fig. 2.63. Elsevier Science Publishers B. V. Amsterdam.
16. Lau, A. H., Lam, N. P., Piscitelli, S. C., Wilkes, L., and Danziger, L. H. (1992): Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. Clin. Pharmacokonet. 23 (5) Nov., 328-64.
17. Leatherland, J. F. (1992): Endocrine and reproductive function in Great Lakes salmon. In T. Colburn and C. Clement, eds., Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection, Vol. 21 - Advances in Modern Environmental Toxicology. Princeton Scientific, Princeton, NJ, 129-145.
18. Lund, W. (Ed.) (1994): The Pharmaceutical Codex. Principles and Practice of Pharmaceutics. 12th Edition. The Pharmaceutical Press, London.
19. Læegemiddelstatistik i Danmark 1995. Læegemiddelstyrelsen ISBN 87-90301-08-0. Schultz Erhvervsboghandel, Vognmagergade 7, 1120 København K., Denmark (in danish).
20. Mackay, D. (1991): Multimedia Environmental Models. The fugacity approach. Lewis Publishers INC., Michigan, USA.
21. Macri, A., Stazi, A. V., and Dojmi Di Delupis, G. (1988): Acute Toxicity of Furazolidone on Artemia salina, Daphnia magna. and Culex pipiens molestus Larvae. Ecotoxicology and Environmental Safety 16, 90-94.
22. Mayer, P., Cuhel, R., and Nyhohm, N. (in press): A simple in vitro fluorescence method for biomass measurements in algal growth inhibition tests. Water Research.
23. Meylan, W. M. and Howard, P. H. (1992): Henry's Law Constant Program. Syracuse Research Corporation. Lewis Publishers. USA.
24. Nyholm, N., Sørensen, P. S., Kusk, K. O. and Christensen, E. R. (1992): Statistical Treatment of Data from Microbial Toxicity Tests. Envrion. Toxicol. Chem. 11. 157-167.
25. Pendland, S. L., Piscitelli, S. C., Schreckenberger, P. C., and Danziger, L. H. (1994): In vitro activities of metronidazole and its hydroxy metabolite against Bacteroides spp. Antimicrob. Agents. Chemother. 38 (9) Sep, 2106-2110.
26. Richardson, M. L. and Bowron, J. M. (1985): Review. The fate of pharmaceutical chemicals in the aquatic environment. J. Pharm. Pharmacol. 37, 1-12.
27. Siegmund, W., Zschiesche, M., Franke, G., and Wilke, A. (1992): Bioavaiability of metronidazole formulations (Vagamid®). Pharmazie 47 (Jul), 522-525.
28. Speck, W. T, Stein, A. B., and Rosenkranz, H. S. (1976): Mutagenicity of metronidazole: presence of several active metabolites in human urine. J. Nail. Cancer Inst. 56. 283-284.
29. Stan, H., Heberer, T, and Linkerhägner, M. (1994): Vorkommen von Clofibrinsäure im aquatiscehn System - Führt die therapeutiche Anvendung zu einer Belastung von Oberflächen-, Grund-und Trinkwasser? Vom Wasser, 83,57-68. (in german)
30. Støttrup, J. G., Richardson, K. Kirkegaard, E., and Pihl, N. J. ( 1986): The cultivation of Acartia tonsa Dana for use as a live food source for marine fish larvae. Aquaculture. 52: 87-96.
31. Tally, F. P. and Sullivan, C. E. (1981): Metronidazole: In Vitro Activity, Phtrmacology and Efficacy in Anaerobic Bacterial Infections. Pharmacotherapy 1(1) July/August, 28-38.
32. Thompson, R. S. (1995): ISO/CD 14669. Water Quality. Determination og acute lethal toxicity to marine copepods (Copepoda, Crustacea). Verion 4 of the method.
33. USP 23. NF 18. The United States Pharmacopeia 1995. The National Formulary. United States Pharmacopeial Convention, Inc. Rockville, MD, USA.
34. WHO (1995): Anatomical Therapeutic Chemical (ATC) classification index - including Defined Daily Doses (DDDs) for plain substances. WHO Collaborating Centre for Drug Statistics Methodology, P.O. Box 100, Veitvet, 0518 Oslo, Norway.