The New York high risk project to the Hillside recognition and prevention (RAP) program

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 114, Issue 8, 2002, Pages 956-966

  Cornblatt, Barbara A ^a,b  

^a ZUCKER HILLSIDE HOSPITAL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Early intervention; Prodrome; Risk factors; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; NEUROLEPTIC AGENT; SEROTONIN UPTAKE INHIBITOR;

ADOLESCENT; COGNITIVE DEFECT; DISEASE COURSE; GENETIC RISK; HEALTH PROGRAM; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MENTAL DISEASE; MENTAL HEALTH CARE; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; REVIEW; RISK FACTOR; SCHIZOPHRENIA; SOCIAL ADAPTATION; SYMPTOMATOLOGY; TREATMENT INDICATION; UNITED STATES;

HUMANS; NEW YORK; RISK FACTORS; SCHIZOPHRENIA;

EID: 0037045148     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.10520     Document Type: Review

References (71)

1. Asarnow RF, Steffy RA, MacCrimmon DJ, Cleghorn JM. 1977. An attentional assessment of foster children at risk for schizophrenia. J Abnormal Psychology 86:267-275.
2. Beiser M, Erickson D, Fleming JA, Iacono WG. 1993. Establishing the onset of psychotic illness. Am J Psychiatry 150:1349-1354.
3. Brown CS, Markowitz JS, Moore TR, Parker NG. 1999. Atypical anti-psychotics. Part II: Adverse effects, drug interactions, and costs. Ann Pharmacother 33:210-217.
4. Cannon TD. 1991. Genetic and perinatal sources of structural brain abnormalities in schizophrenia. In: Mednick SA, Cannon TD, Barr CE, Lyons MJ, editors. Fetal neural development and adult schizophrenia. Cambridge, England: Cambridge University Press. p 174-198.
5. Cannon TD. 1998. Genetic and perinatal influences in the etiology of schizophrenia: A neurodevelopmental model. In: Lenzenweger M, Dworkin RH, editors. Origins and Development of Schizophrenia: Advances in Experimental Psychopathogy. Washington. DC: American Psychological Association. p 67-92.
6. Cannon TD, Mednick SA. 1993. The schizophrenia high-risk project in Copenhagen: Three decades of progress. Acta Psychiatr Scand 370(Suppl):33-47.
7. Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A. 1994. Developmental brain abnormalities in the offspring of schizophrenic mothers. II. Structural brain characteristics of schizophrenia and schizotypal personality disorder. Arch Gen Psychiatry 51:955-962.
8. Cornblatt B. 1989. The continuous performance test-identical pairs (CPT-IP): II. Contrasting profiles of attentional deficits in schizophrenic and depressed patients. Psychiatry Res 29:65-85.
9. Cornblatt B. 1992. Childhood attentional dysfunctions predict social deficits in unaffected adults at risk for schizophrenia. Br J Psychiatry 18(Suppl): 59-64.
10. Cornblatt B, Erlenmeyer-Kimling L. 1985. Global attentional deviance as a marker of risk for schizophrenia: Specificity and predictive validity. J Abnormal Psychology 94:470-485.
11. Cornblatt BA, Keilp JG. 1994. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20:31-46.
12. Cornblatt B, Obuchowski M. 1997. Update of high-risk research: 1987-1997. Int Rev Psychiatry 9:437-447.
13. Cornblatt B, Obuchowski M, Schnur DB, O'Brien JD. 1997. Attention and clinical symptoms in schizophrenia. Psychiatr Q 68:343-359.
14. Cornblatt B, Obuchowski M, Roberts S, Pollack S, Erlenmeyer-Kimling L. 1999. Cognitive and behavioral precursors of schizophrenia. Dev Psychopathol 11:487-508.
15. Cornblatt B, Lencz T, Kane J. 2001. Treatment of the schizophrenia prodrome: Is it presently ethical? Schizophr Res 51:31-38.
16. Cornblatt B, Lencz T, Obuchowski M. 2002. The schizophrenia prodrome: Treatment and high-risk perspectives. Schizophr Res 54:177-186.
17. DeQuardo JR, Tandon R. 1998. Do atypical antipsychotic medications favorably alter the long-term course of schizophrenia? J Psychiatr Res 32:229-242.
18. Duzyurek S. 1999. Early recognition in schizophrenia: The prodromal stages. J Prac Psych Behav Health 5:187-196.
19. Dworkin RH, Bernstein G, Kaplanski LM, Lipsitz JD, Rinaldi A, Slater SL, Cornblatt B, Erlenmeyer-Kimling L. 1991. Social competence and positive and negative symptoms: A longitudinal study of children and adolescents at risk for schizophrenia and affective disorder. Am J Psychiatry 148:1182-1188.
20. Dworkin RH, Cornblatt B, Friedmann R, Kaplanski LM, Lewis JA, Rinaldi A, Shilliday C, Erlenmeyer-Kimling L. 1993. Childhood precursors of affective vs. social deficits in adolescents at risk for schizophrenia. Schizophr Bull 19(3):563-577.
21. Erlenmeyer-Kimling L. 1990. High-risk children in adolescence and young adulthood: Course of global adjustment. In: Robins L, Rutter M, editors. Straight and Devious Pathways From Childhood to Adulthood. Cambridge: Cambridge University Press. p 351-364.
22. Erlenmeyer-Kimling L. 2000. Neurobehavioral deficits in offspring of schizophrenic parents: Liability indicators and predictors of illness. Am J Med Genet 97:65-71.
23. Erlenmeyer-Kimling L, Cornblatt B. 1978. Attentional measures in a study of children at high-risk for schizophrenia. J Psychiatr Res 14:93-98.
24. Erlenmeyer-Kimling L, Cornblatt B. 1984. Biobehavioral risk factors in children of schizophrenic parents. J Autism Dev Disord 14:357-374.
25. Erlenmeyer-Kimling L, Cornblatt B. 1987. The New York High-Risk Project: A followup report. Schizophr Bull 13:451-461.
26. Erlenmeyer-Kimling L, Cornblatt B. 1992. A summary of attentional findings in the New York High-Risk Project. J Psychiatr Res 26:405-426.
27. Erlenmeyer-Kimling L, Cornblatt B, Friedman D, Marcuse Y, Rutschmann J, Simmens S, Devi S. 1982. Neurological, electrophysiological, and attentional deviations in children at risk for schizophrenia. In: Nasrallah HA, Henn FA, editors. Schizophrenia as a Brain Disease. New York: Oxford University Press. p 61-82.
28. Erlenmeyer-Kimling L, Squires-Wheeler E, Adamo UH, Bassett AS, Cornblatt B, Kestenbaum CJ, Rock D, Roberts SA, Gottesman II. 1995. The New York High-Risk Project. Psychoses and cluster A personality disorders in offspring of schizophrenic parents at 23 years of follow-up. Arch Gen Psychiatry 52:857-865.
29. Erlenmeyer-Kimling L, Rock D, Roberts SA, Janal M, Kestenbaum C, Cornblatt B, Adamo UH, Gottesman II. 2000. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: The New York High-Risk Project. Am J Psychiatry 157:1416-1422.
30. Grunebaum H, Weiss JL, Gallant D, Cohler BJ. 1974. Attention in young children of psychotic mothers. Am J Psychiatry 131:887-891.
31. Haas GL, Garratt LS, Sweeney JA. 1998. Delay to first antipsychotic medication in schizophrenia: Impact on symptomatology and clinical course of illness. J Psychiatr Res 32:151-159.
32. Hans SL, Marcus JM. 1991. Neurobehavioral development of infants at risk for schizophrenia: A review. In: Walker E, editor. Schizophrenia: A Life Course Development Perspective. Orlando: Academic Press Inc. p 33-57.
33. Ingraham DJ, Kugelmass S, Frenkel E, Nathan M, Mirsky AF. 1995. Twenty-five-year followup of the Israeli High-Risk Study: Current and lifetime psychopathology. Schizophr Bull 21:183-192.
34. Johnstone EC, Abukmeil SS, Byrne M, Clafferty R, Grant E, Hodges A, Lawrie SM, Owens DG. 2000. Edinburgh high risk study - Findings after four years: Demographic, attainment and psychopathological issues. Schizophr Res 46:1-15.
35. Jones P, Murray RM. 1991. The genetics of schizophrenia is the genetics of neurodevelopment. Br J Psychiatry 158:615-623.
36. Kraemer HC, Stice E, Kazdin A, Offord D, Kupfer D. 2001. How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. Am J Psychiatry 158:848-856.
37. Lewis R. 1998. Typical and atypical antipsychotics in adolescent schizophrenia: Efficacy, tolerability, and differential sensitivity to extrapyramidal symptoms. Can J Psychiatry 43:596-604.
38. Lieberman JA, Perkins D, Belger A, Chakos M, Jarskog F, Boteva K, Gilmore J. 2001. The early stages of schizophrenia: Speculations on pathogenesis, pathophysiology and therapeutic approaches. Biol Psychiatry 50:884-897.
39. Loebel AD, Lieberman JA, Alvir JM, Mayerhoff DI, Geisler SH, Szymanski SR. 1992. Duration of psychosis and outcome in first-episode schizophrenia. Am J Psychiatry 149:1183-1188.
40. Marcus J, Hans SL, Auerbach JG, Auerbach AG. 1993. Children at risk for schizophrenia: The Jerusalem Infant Development Study. II. Neurobehavioral deficits at school age. Arch Gen Psychiatry 50:797-809.
41. McGlashan TH. 1998. Early detection and intervention of schizophrenia: Rationale and research. Br J Psychiatry 172(Suppl):3-6.
42. McGlashan TH. 2001. Psychosis treatment prior to psychosis onset: Ethical issues. Schizophr Res 51:47-54.
43. McGlashan TH, Johannessen JO. 1996. Early detection and intervention with schizophrenia: Rationale. Schizophr Bull 22:201-222.
44. McGlashan TH, Miller TJ, Woods SW. 2001. Pre-onset detection and intervention research in schizophrenia psychoses. Schizophr Bull 27: 563-570.
45. McGorry PD. 1995. The prevalence of prodromal features of schizophrenia in adolescence: A preliminary survey. Acta Psychiatr Scand 92:241-249.
46. McGorry P, Yung A, Phillips L. 1999. People at risk of schizophrenia and other psychoses: Comments on the Edinburgh High-Risk Study. Br J Psychiatry 175:586-587.
47. McGorry PD, McKenzie D, Jackson HJ, Waddell F, Curry C. 2000. Can we improve the diagnostic efficiency and predictive power of prodromal symptoms for schizophrenia? Schizophr Res 42:91-100.
48. Mednick SA. 1968. Some premorbid characteristics related to breakdown in children with schizophrenic mothers. J Psychiatr Res 6:267-291.
49. Mednick SA, Parnas J, Schulsinger F. 1987. The Copenhagen High-Risk Project, 1962-1986. Schizophr Bull 13:485-495.
50. Miller TJ, McGlashan TH, Woods SW, Stein K, Driesen N, Corcoran CM, Hoffman R, Davidson L. 1999. Symptom assessment in schizophrenic prodromal states. Psychiatr Q 70:273-287.
51. Mirsky AF, Kugelmass S, Ingraham LJ, Frenkel E, Nathan M. 1995. Overview and summary: 25 Year follow-up of high risk children. Schizophr Bull 21:227-239.
52. Murray RM, O'Callaghan E, Castle DJ, Lewis SW. 1992. A neurodevelopmental approach to the classification of schizophrenia. Schizophr Bull 18:319-332.
53. Nuechterlein KH. 1983. Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. J Abnorm Psychol 92:4-28.
54. Nuechterlein KH, Dawson ME. 1984. Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bull 10:160-203.
55. Olin SC, Mednick SA. 1996. Risk factors of psychosis: Identifying vulnerable populations premorbidly. Schizophr Bull 22:223-240.
56. Phillips L, Yung AR, Hearn N, McFarlane C, Hallgren M, McGorry PD. 1999. Preventative mental health care: Accessing the target population. Aust NZ J Psychiatry 33:912-917.
57. Rutschmann J, Cornblatt B, Erlenmeyer-Kimling L. 1977. Sustained attention in children at risk for schizophrenia. Report on a continuous performance test. Arch Gen Psychiatry 34:571-575.
58. Rutschmann J, Cornblatt B, Erlenmeyer-Kimling L. 1980. Auditory recognition memory in adolescents at risk for schizophrenia: Report on a verbal continuous recognition task. Psychiatry Res 3:151-161.
59. Siever LJ, Kalus OF, Okeefe RS. 1993. The boundaries of schizophrenia. Psychiatr Clin North Am 16:217-244.
60. Tienari P, Wynne LC, Moring J, Lahti I, Naarala M, Sorri A, Wahlberg KE, Saarento O, Seitamaa M, Kaleva M. 1994. The Finnish adoptive family study of schizophrenia. Implications for family research. Br J Psychiatry 23(Suppl):20-26.
61. Tsuang MT. 2000. Schizophrenia: Genes and environment. Biol Psychiatry 47:210-220.
62. Tsuang MT, Stone WS, Faraone SV. 2000a. Toward reformulating the diagnosis of schizophrenia. Am J Psychiatry 157:1041-1050.
63. Tsuang MT, Stone WS, Faraone SV. 2000b. Towards the prevention of schizophrenia. Biol Psychiatry 48:349-356.
64. Weinberger D. 1987. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44:660-669.
65. Weinberger D. 1995. From neuropathology to neurodevelopment. Lancet 346:552-557.
66. Winters L, Cornblatt B, Erlenmeyer-Kimling L. 1991. The prediction of psychiatric disorders in late adolescence. In: Walker E, editor. Schizophrenia: A Life Course Developmental Perspective. New York: Academic Press. p 123-137.
67. Wyatt RJ, Henter ID. 1998. The effects of early and sustained intervention on the long-term morbidity of schizophrenia. J Psychiatr Res 32:169-177.
68. Wyatt RJ, Green MF, Tuma AH. 1997. Long-term morbidity associated with delayed treatment of first admission schizophrenic patients: A re-analysis of the Camarillo State Hospital data. Psychol Med 27:261-268.
69. Yung AR, McGorry PD. 1996a. The prodromal phase of first-episode psychosis: Past and current conceptualizations. Schizophr Bull 22:353-370.
70. Yung AR, McGorry PD. 1996b. The initial prodrome in psychosis: Descriptive and qualitative aspects. Aust NZ J Psychiatry 30:587-599.
71. Yung AR, Phillips LJ, McGorry PD, McFarlane CA, Francey S, Harrigan S, Patton GC, Jackson HJ. 1998. Prediction of psychosis. A step towards indicated prevention of schizophrenia. Br J Psychiatry 172(Suppl): 14-20.