Electrostatic channeling of substrates between enzyme active sites: Comparison of simulation and experiment

Biochemistry

Volumn 36, Issue 51, 1997, Pages 16049-16058

  Elcock, Adrian H ^a   Huber, Gary A ^a   Andrew McCammon, J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CITRATE SYNTHASE; MALATE DEHYDROGENASE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIMULATION;

ASPARTATE AMINOTRANSFERASES; BINDING SITES; CATALYSIS; CITRATE (SI)-SYNTHASE; ELECTROCHEMISTRY; ELECTROSTATICS; ENZYME INHIBITORS; ENZYMES; KINETICS; MALATE DEHYDROGENASE; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; OSMOLAR CONCENTRATION; RECOMBINANT FUSION PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDINE MONOPHOSPHATE; THYMIDYLATE SYNTHASE;

EID: 0031406496     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971709u     Document Type: Article

References (27)

1. Meek, T. D., Garvey, E. P., and Santi, D. V. (1985) Biochemistry 24, 678-686.
2. Trujillo, M., Donald, R. G. K., Roos, D. S., Greene, P. J., and Santi, D. V. (1996) Biochemistry 35, 6366-6374.
3. Bülow, L., Ljungcrantz, P., and Mosbach, K. (1985) Bio/Technology 3, 821-823.
4. Ljungcrantz, P., Carlsson, H., Mansson, M. O., Buckel, P., Mosbach, K., and Bülow, L. (1989) Biochemistry 28, 8786-8792.
5. Lindbladh, C., Rault, M., Hagglund, C., Small, W. C., Mosbach, K., Blow, L., Evans, C., and Srere, P. A. (1994) Biochemistry 33, 11692-11698.
6. Ovádi, J. (1991) J. Theor. Biol. 151, 1-22.
7. Ovádi, J., and Srere, P. A. (1992) Trends Biochem. Sci. 17, 445-447.
8. Welch, G. R., and Easterby, J. S. (1994) Trends Biochem. Sci. 19, 193-197.
9. Hyde, C. C., Ahmed, S. A., Padlan, E. A., Miles, E. W., and Davies, D. R. (1988) J. Biol. Chem. 263, 17857-17871.
10. Pan, P., Woehl, E., and Dunn, M. F. (1997) Trends Biochem. Sci. 22, 22-27.
11. Knighton, D. R., Kan, C.-C., Howland, E., Janson, C. A., Hostomska, Z., Welsh, K. M., and Matthews, D. A. (1994) Nature Struct. Biol. 1, 186-194.
12. Stroud, R. M. (1994) Nature Struct. Biol. 1, 131-134.
13. Elcock, A. H., Potter, M. J., Matthews, D. A., Knighton, D. R., and McCammon, J. A. (1996) J. Mol. Biol. 262, 370-374.
14. Elcock, A. H., and McCammon, J. A. (1996) Biochemistry 35, 12652-12658.
15. Madura, J. D., Davis, M. E., Gilson, M. K., Wade, R. C., Luty, B. A., and McCammon, J. A. (1994) Rev. Comp. Chem. 5, 229-267.
16. Madura, J. D., Briggs, J. M., Wade, R. C., Davis, M. E., Luty, B. A., Ilin, A., Antosiewicz, J., Gilson, M. K., Bagheri, B., Scott, L. R., and McCammon, J. A. (1995) Comp. Phys. Comm. 91, 57-95.
17. Wade, R. C. (1996) Biochem. Soc. Trans. 24, 254-259.
18. Honig, B., and Nicholls, A. (1995) Science 268, 1144-1149.
19. Easterby, J. S. (1973) Biochim. Biophys. Acta 293, 552-558.
20. Easterby, J. S. (1981) Biochem. J. 199, 155-161.
21. Ovádi, J., Tompa, P., Vértessy, B., Orosz, F., Keleti, T., and Welch, G. R. (1989) Biochem. J. 257, 187-190.
22. Tompa, P., Batke, J., and Ovádi, J. (1987) FEBS Lett. 214, 244-248.
23. Voet, D., and Voet, J. G. (1995) Biochemistry, 2nd ed., Wiley, New York.
24. Fersht, A. (1985) Enzyme Structure and Mechanism, Freeman, New York.
25. Press, W. H., Teukolsky, S. A., Vetterling, W. T., and Flannery, B. P. (1992) Numerical Recipes in FORTRAN, Cambridge University Press, Cambridge, U.K.
26. Goldberg, J. M., and Kirsch, J. F. (1996) Biochemistry 35, 5280-5291.
27. Sigmaplot (1994) Jandel Scientific Software, San Rafael, CA. BI971709U