Trypanosome mitochondrial 3′ terminal uridylyl transferase (TUTase): The key enzyme in U-insertion/deletion RNA editing

Cell

Volumn 108, Issue 5, 2002, Pages 637-648

  Aphasizhev, Ruslan ^a   Sbicego, Sandro ^a   Peris, Marian ^c   Jang, Sei Heon ^b   Aphasizheva, Inna ^a   Simpson, Agda M ^a   Rivlin, Anatoly ^a   Simpson, Larry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Daegu University   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; HEXOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; MAGNESIUM ION; MITOCHONDRIAL RNA; OLIGOMER; RNA LIGASE;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME PURIFICATION; ENZYME SPECIFICITY; GENE DELETION; GENE EXPRESSION; GENE INSERTION; LEISHMANIA TARENTOLAE; MITOCHONDRION; MOLECULAR CLONING; MOLECULAR SIZE; NONHUMAN; PRIORITY JOURNAL; RNA EDITING; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

INSERTION SEQUENCES; LEISHMANIA TARENTOLAE; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0037040412     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00647-5     Document Type: Article

References (53)

1. Modification of Trypanosoma brucei mitochondrial rRNA by posttranscriptional 3′ polyuridine tail formation
2. The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria
3. Purification of a terminal uridylyltransferase that acts as host factor in the in vitro poliovirus replicase reaction
4. Isolation and characterization of a U-specific 3′-5′ exonuclease from mitochondria of Leishmania tarentolae
5. DNA polymerase beta-like nucleotidyltransferase superfamily: Identification of three new families, classification, and evolutionary history
6. The Leishmania kinetoplast-mitochondrion contains terminal uridylyltransferase and RNA ligase activities
7. Structure of yeast poly(A) polymerase alone and in complex with 3′-dATP
8. The mitochondrial RNA ligase from Leishmania tarentolae can join RNA molecules bridged by a complementary RNA
9. Cloning and characterization of two guide RNA-binding proteins from mitochondria of Crithidia fasciculata: gBP27, a novel protein, and gBP29, the orthologue of Trypanosoma brucei gBP21
10. Guide RNAs in kinetoplastid mitochondria have a nonencoded 3′ oligo-(U) tail involved in recognition of the preedited region
11. Isolation of kinetoplast-mitochondrial complexes from Leishmania tarentolae
12. Mitochondrial glutamate dehydrogenase from Leishmania tarentolae is a guide RNA-binding protein
13. Sequence of a cDNA for the ND1 gene from Leishmania major: Potential uridine addition in the polyadenosine tail
14. High-efficiency clonal growth of bloodstream- and insect-form Trypanosoma brucei on agarose plates
15. Separation of factors required for cleavage and polyadenylation of yeast pre-mRNA
16. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
17. Uridine insertion/deletion RNA editing in trypanosome mitochondria - A review
18. Knockout of the glutamate dehydrogenase gene in bloodstream Trypanosoma brucei in culture has no effect on editing of mitochondrial mRNAs
19. In vitro RNA editing-like activity in a mitochondrial extract from Leishmania tarentolae
20. Telomerase is processive
21. DNA polymerase beta belongs to an ancient nucleotidyltransferase superfamily
22. Uridylate addition and RNA ligation contribute to the specificity of kinetoplastid insertion RNA editing
23. In vitro uridine insertion RNA editing mediated by cis-acting guide RNAs
24. Trypanosoma brucei gBP21. An arginine-rich mitochondrial protein that binds to guide RNA with high affinity
25. Double-stranded RNA interference in Trypanosoma brucei using head-to-head promoters
26. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
27. Kinetoplastid RNA-editing-associated protein 1 (REAP-1): A novel editing complex protein with repetitive domains
28. Mutational analysis of mammalian poly(A) polymerase identifies a region for primer binding and catalytic domain, homologous to the family X polymerases, and to other nucleotidyltransferases
29. Tailing and 3′-end labeling of RNA with yeast poly(A) polymerase and various nucleotides
30. Mapping of ATP binding regions in poly(A) polymerases by photoaffinity labeling and by mutational analysis identifies a domain conserved in many nucleotidyltransferases
31. Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP
32. Trypanosoma brucei guide RNA poly(U) tail formation is stabilized by cognate mRNA
33. Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei
34. Association of poly(A) and poly(U) polymerases with cytoplasmic ribosomes
35. UTP-dependent and -independent pathways of mRNA turnover in Trypanosoma brucei mitochondria
36. Disruption of a gene encoding a novel mitochondrial DEAD-box protein in Trypanosoma brucei affects edited mRNAs
37. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
38. Association of two novel proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA editing complex
39. Four related proteins of the Trypanosoma brucei RNA editing complex
40. Native gel analysis of ribonucleoprotein complexes from a Leishmania tarentolae mitochondrial extract
41. Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria
42. The two RNA ligases of the Trypanosoma brucei RNA editing complex: Cloning the essential band IV gene and identifying the band V gene
43. RNA ligase and its involvement in guide RNA/mRNA chimera formation
44. Poly(A) tail metabolism and function in eucaryotes
45. An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei
46. On the role of RNA amplification in dsRNA-triggered gene silencing
47. U-insertion/deletion edited sequence database
48. A highly specific terminal uridylyl transferase modifies the 3′-end of U6 small nuclear RNA
49. Trypanosoma brucei TBRGG1, a mitochondrial oligo(U)-binding protein that colocalizes with an in vitro RNA editing activity
50. Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters
51. RNA end-labeling and RNA ligase activities can produce a circular ribosomal RNA in whole-cell extracts from trypanosomes
52. A tightly regulated inducible expression system for conditional gene knockouts and dominant-negative genetics in Trypanosoma brucei
53. Terminal uridylyl transferase of vigna unguiculata: Purification and characterization of an enzyme catalyzing the addition of a single UMP residue to the 3′-end of an RNA primer