Kinetoplastid RNA-editing-associated protein 1 (REAP-1): A novel editing complex protein with repetitive domains

EMBO Journal

Volumn 17, Issue 21, 1998, Pages 6368-6376

  Madison Antenucci, Susan ^a   Sabatini, Robert S ^a   Pollard, Victoria W ^a,b   Hajduk, Stephen L ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Kinetoplastid RNA REAP 1; Ribonucleoprotein (RNP) complex; RNA editing

Indexed keywords

MESSENGER RNA; MONOCLONAL ANTIBODY; NUCLEOTIDYLTRANSFERASE; RIBONUCLEASE; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; RNA LIGASE; URIDINE;

ANIMAL EXPERIMENT; ARTICLE; FEMALE; GENETIC CONSERVATION; KINETOPLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA EDITING; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; FLUORESCENT ANTIBODY TECHNIQUE; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; RNA; RNA EDITING; RNA LIGASE (ATP); RNA NUCLEOTIDYLTRANSFERASES; SEQUENCE ANALYSIS, DNA; TRYPANOSOMA BRUCEI BRUCEI;

ANIMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0032476738     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.21.6368     Document Type: Article

References (28)

1. Adler, B. and Hajduk, S.L. (1994) Mechanisms and origins of RNA editing. Curr. Opin. Genet. Dev., 4, 316-322.
2. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K. (eds) (1989) Current Protocols in Molecular Biology. Greene Publishing Associates and Wiley-Interscience.
3. Benne, R. (1994) RNA editing in trypanosomes. Eur. J. Biochem., 221, 9-23.
4. Bringaud, F, Peris, M., Zen, K.H. and Simpson, L. (1995) Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae. Mol. Biochem. Parasitol., 71, 65-79.
5. Bruck, C., Portetelle, D., Glineur, C. and Bollen, A. (1982) One-step purification from ascitic fluid by DEAE Affi-Gel Blue chromatography. J. Immunol. Methods. 53, 33-42.
6. Campbell, D., Thornton, D. and Boothroyd, J. (1984) Apparent discontinous transcription of Trypanosoma brucei variant surface antigen genes. Nature, 311, 350-355.
7. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
8. Corell, R.A. et al. (1996) Complexes from Trypanosoma brucei that exibit deletion editing and other editing-associated properties. Mol. Cell. Biol., 16, 1410-1418.
9. Cruz-Reyes, J. and Sollner-Webb, B. (1996) Trypanosome U-deletional RNA editing involves guide RNA-directed endonuclease cleavage, terminal U exonuclease and RNA ligase activities. Proc. Natl Acad. Sci. USA, 93, 8901-8906.
10. Harris, M.E., Moore, D.R. and Hajduk, S.L. (1990) Addition of undines to edited RNAs in trypanosome mitochondria occurs independently of transcription. J. Biol. Chem., 265, 11368-11376.
11. Kable, M.L., Seiwert, S.D., Heidmann, S. and Stuart, K. (1996) RNA editing: a mechanism for gRNA-specified uridylate insertion into precursor mRNA. Science, 273, 1189-1195.
12. Koller, J., Muller, U., F., Schmid, B., Missel, A., Kruft, V., Stuart, K. and Goringer, H.U. (1997) Trypanosoma brucei gBP21: an arginine-rich mitochondrial protein that binds to guide RNA with high affinity. J. Biol. Chem., 272, 3749-3757.
13. Laemmli, U.K. ( 1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
14. Michelotti, E.F. and Hajduk, S.L. (1987) Developmental regulation of trypanosome mitochondrial gene expression. J. Biol. Chem., 262, 927-932.
15. Missel, A. and Goringer, H.U. (1994) Trypanosoma brucei mitochondria contain RNA helicase activity. Nucleic Acids Res., 22, 4050-4056.
16. Peris, M., Simpson, A.M., Grunstein, J., Liliental, J.E., Frech, G.C. and Simpson, L. (1997) Native gel analysis of ribonucleoprotein complexes from a Leishmania tarentolae mitochondrial extract. Mol. Biochem. Parasitol., 85, 9-24.
17. Piller, KJ., Decker, C.J., Rusche, L.N. and Sollner-Webb, B. (1995) Trypanosoma brucei mitochondrial guide RNA-mRNA chimeraforming activity cofractionates with an editing-domain specific endonuclease and RNA ligase and is mimicked by heterologous nuclease and RNA ligase. Mol. Cell. Biol., 15, 2925-2932.
18. Pollard, V.W. and Hajduk, S.L. (1991) Trypanosoma equiperdum minicircles encode three distinct primary transcripts which exhibit guide RNA characteristics. Mol. Cell. Biol., 11, 1668-1675.
19. Pollard, V.W., Harris, M.E. and Hajduk, S.L. (1992) Native mRNA editing complexes from Trypanosoma brucei mitochondria. EMBO J., 11, 4429-4438.
20. Priest, J.W. and Hajduk, S.L. (1994) Developmental regulation of Trypanosoma brucei cytochrome c reductase during bloodstream to procyclic differentiation. Mol. Biochem. Parasitol., 65, 291-304.
21. Priest, J.W. and Hajduk, S.L. (1995) The trypanosomatid Rieske iron-sulfur proteins have a cleaved presequence that may direct mitochondrial import. Biochim. Biophys. Acta., 1269, 201-204.
22. Rusché, L.R., Cruz-Reyes, J., Piller, K.J. and Sollner-Webb, B. (1997) Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria. EMBO J., 16, 4069-4081.
23. Sabatini, R. and Hajduk, S.L. (1995) RNA ligase and its involvement in guide RNA/mRNA chimera formation. Evidence for a cleavage-ligation mechanism of Trypanosoma brucei mRNA editing. J. Biol. Chem., 270, 7233-7240.
24. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Labaoratory Manual 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
25. Seiwert, S.D. (1995) The ins and outs of editing RNA in kinetoplastids. Parasitol. Today, 11, 362-368.
26. Seiwert, S.D., Heidmann, S. and Stuart, K. (1996) Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editing. Cell 84, 831-841.
27. Simpson, L. and Thiemann, O.H. (1995) Sense from nonsense: RNA editing in mitochondria of kinetoplastid protozoa and slime molds. Cell. 81, 837-840.
28. Speijer, D., Breek, C.K., Muijsers, A.O., Hartog, A.F., Berden, J.A., Albracht, S.P., Samyn, B., Van Beeumen, J. and Benne, R. (1997) Characterization of the respiratory chain from cultured Crithidia fasciculata. Mol. Biochem. Parasitol., 85, 171-186.