Global replacement of tryptophan with aminotryptophans generates non-invasive protein-based optical pH sensors

Angewandte Chemie - International Edition

Volumn 41, Issue 21, 2002, Pages 4066-4069

  Budisa, Nediljko ^a   Rubini, Marina ^a   Bae, Jae H ^a   Weyher, Elisabeth ^a   Wenger, Waltraud ^a   Golbik, Ralph ^b   Huber, Robert ^a   Moroder, Luis ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Amino acids; Biosensors; Gene expression; Protein engineering; Tryptophan

Indexed keywords

AMINO ACIDS; OPTICAL PROPERTIES; PH EFFECTS; SENSORS;

MOLECULAR SENSORS;

PROTEINS;

BACTERIAL PROTEIN; BARSTAR; DRUG DERIVATIVE; PROTEIN; TRYPTOPHAN;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; FLUORESCENCE; GENETIC PROCEDURES; INSTRUMENTATION; METHODOLOGY; MOLECULAR INTERACTION; NUCLEOTIDE SEQUENCE; OPTICS; PH; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTON TRANSPORT; SENSOR; SPECTROSCOPY; SYNTHESIS; TRANSLATION REGULATION; ULTRAVIOLET SPECTROPHOTOMETRY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; BIOSENSING TECHNIQUES; FLUORESCENCE; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; OPTICS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPTOPHAN;

EID: 0037021021     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20021104)41:21<4066::AID-ANIE4066>3.0.CO;2-6     Document Type: Article

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